PDB entry 1fpz

View 1fpz on RCSB PDB site
Description: crystal structure analysis of kinase associated phosphatase (kap) with a substitution of the catalytic site cysteine (cys140) to a serine
Class: hydrolase
Keywords: alpha-beta sandwich, HYDROLASE
Deposited on 2000-09-01, released 2001-05-09
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-04-14, with a file datestamp of 2009-04-10.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.202
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase inhibitor 3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16667
      • mutation (139)
    Domains in SCOPe 2.06: d1fpza_
  • Chain 'B':
    Compound: cyclin-dependent kinase inhibitor 3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16667
      • mutation (139)
    Domains in SCOPe 2.06: d1fpzb_
  • Chain 'C':
    Compound: cyclin-dependent kinase inhibitor 3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16667
      • mutation (139)
    Domains in SCOPe 2.06: d1fpzc_
  • Chain 'D':
    Compound: cyclin-dependent kinase inhibitor 3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16667
      • mutation (139)
    Domains in SCOPe 2.06: d1fpzd_
  • Chain 'E':
    Compound: cyclin-dependent kinase inhibitor 3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16667
      • mutation (139)
    Domains in SCOPe 2.06: d1fpze_
  • Chain 'F':
    Compound: cyclin-dependent kinase inhibitor 3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16667
      • mutation (139)
    Domains in SCOPe 2.06: d1fpzf_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1fpzA (A:)
mkppssiqtsefdssdeepiedeqtpihiswlslsrvncsqflglcalpgckfkdvrrnv
qkdteelkscgiqdifvfctrgelskyrvpnlldlyqqcgiithhhpiadggtpdiascc
eimeelttclknyrktlihsygglgrsclvaaclllylsdtispeqaidslrdlrgsgai
qtikqynylhefrdklaahlssrdsqsrsvsr

    Sequence, based on observed residues (ATOM records): (download) 
    >1fpzA (A:)
tpihiswlslsrvncsqflglcalpgckfkdvrrnvqkdteelkscgiqdifvfctrgel
skyrvpnlldlyqqcgiithhhpiadggtpdiascceimeelttclknyrktlihsyggl
grsclvaaclllylsdtispeqaidslrdlrgsgaiqtikqynylhefrdklaahl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1fpzB (B:)
mkppssiqtsefdssdeepiedeqtpihiswlslsrvncsqflglcalpgckfkdvrrnv
qkdteelkscgiqdifvfctrgelskyrvpnlldlyqqcgiithhhpiadggtpdiascc
eimeelttclknyrktlihsygglgrsclvaaclllylsdtispeqaidslrdlrgsgai
qtikqynylhefrdklaahlssrdsqsrsvsr

    Sequence, based on observed residues (ATOM records): (download) 
    >1fpzB (B:)
tpihiswlslsrvncsqflglcalpgckfkdvrrnvqkdteelkscgiqdifvfctrgel
skyrvpnlldlyqqcgiithhhpiadggtpdiascceimeelttclknyrktlihsyggl
grsclvaaclllylsdtispeqaidslrdlrgsgaiqtikqynylhefrdklaahl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1fpzC (C:)
mkppssiqtsefdssdeepiedeqtpihiswlslsrvncsqflglcalpgckfkdvrrnv
qkdteelkscgiqdifvfctrgelskyrvpnlldlyqqcgiithhhpiadggtpdiascc
eimeelttclknyrktlihsygglgrsclvaaclllylsdtispeqaidslrdlrgsgai
qtikqynylhefrdklaahlssrdsqsrsvsr

    Sequence, based on observed residues (ATOM records): (download) 
    >1fpzC (C:)
eqtpihiswlslsrvncsqflglcalpgckfkdvrrnvqkdteelkscgiqdifvfctrg
elskyrvpnlldlyqqcgiithhhpiadggtpdiascceimeelttclknyrktlihsyg
glgrsclvaaclllylsdtispeqaidslrdlrgsgaiqtikqynylhefrdklaahl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1fpzD (D:)
mkppssiqtsefdssdeepiedeqtpihiswlslsrvncsqflglcalpgckfkdvrrnv
qkdteelkscgiqdifvfctrgelskyrvpnlldlyqqcgiithhhpiadggtpdiascc
eimeelttclknyrktlihsygglgrsclvaaclllylsdtispeqaidslrdlrgsgai
qtikqynylhefrdklaahlssrdsqsrsvsr

    Sequence, based on observed residues (ATOM records): (download) 
    >1fpzD (D:)
eqtpihiswlslsrvncsqflglcalpgckfkdvrrnvqkdteelkscgiqdifvfctrg
elskyrvpnlldlyqqcgiithhhpiadggtpdiascceimeelttclknyrktlihsyg
glgrsclvaaclllylsdtispeqaidslrdlrgsgaiqtikqynylhefrdklaahl

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1fpzE (E:)
mkppssiqtsefdssdeepiedeqtpihiswlslsrvncsqflglcalpgckfkdvrrnv
qkdteelkscgiqdifvfctrgelskyrvpnlldlyqqcgiithhhpiadggtpdiascc
eimeelttclknyrktlihsygglgrsclvaaclllylsdtispeqaidslrdlrgsgai
qtikqynylhefrdklaahlssrdsqsrsvsr

    Sequence, based on observed residues (ATOM records): (download) 
    >1fpzE (E:)
tpihiswlslsrvncsqflglcalpgckfkdvrrnvqkdteelkscgiqdifvfctrgel
skyrvpnlldlyqqcgiithhhpiadggtpdiascceimeelttclknyrktlihsyggl
grsclvaaclllylsdtispeqaidslrdlrgsgaiqtikqynylhefrdklaahl

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1fpzF (F:)
mkppssiqtsefdssdeepiedeqtpihiswlslsrvncsqflglcalpgckfkdvrrnv
qkdteelkscgiqdifvfctrgelskyrvpnlldlyqqcgiithhhpiadggtpdiascc
eimeelttclknyrktlihsygglgrsclvaaclllylsdtispeqaidslrdlrgsgai
qtikqynylhefrdklaahlssrdsqsrsvsr

    Sequence, based on observed residues (ATOM records): (download) 
    >1fpzF (F:)
eqtpihiswlslsrvncsqflglcalpgckfkdvrrnvqkdteelkscgiqdifvfctrg
elskyrvpnlldlyqqcgiithhhpiadggtpdiascceimeelttclknyrktlihsyg
glgrsclvaaclllylsdtispeqaidslrdlrgsgaiqtikqynylhefrdklaahl