PDB entry 1foe

View 1foe on RCSB PDB site
Description: crystal structure of rac1 in complex with the guanine nucleotide exchange region of tiam1
Class: signaling protein, immune system/signaling protein
Keywords: dbl homology domain, pleckstrin homology domain, gtpase, guanine nucleotide exchange factor
Deposited on 2000-08-27, released 2001-01-17
The last revision prior to the SCOP 1.75 freeze date was dated 2001-01-17, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.262
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: t-lymphoma invasion and metastasis inducing protein 1
    Species: MUS MUSCULUS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q60610
      • modified residue (33)
      • modified residue (61)
      • modified residue (194)
      • modified residue (204)
      • modified residue (234)
      • modified residue (304)
    Domains in SCOP 1.75: d1foea1, d1foea2
  • Chain 'B':
    Compound: ras-related c3 botulinum toxin substrate
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1foeb_
  • Chain 'C':
    Compound: t-lymphoma invasion and metastasis inducing protein 1
    Species: MUS MUSCULUS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q60610
      • modified residue (33)
      • modified residue (61)
      • modified residue (194)
      • modified residue (204)
      • modified residue (234)
      • modified residue (304)
    Domains in SCOP 1.75: d1foec1, d1foec2
  • Chain 'D':
    Compound: ras-related c3 botulinum toxin substrate
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1foed_
  • Chain 'E':
    Compound: t-lymphoma invasion and metastasis inducing protein 1
    Species: MUS MUSCULUS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q60610
      • modified residue (33)
      • modified residue (61)
      • modified residue (194)
      • modified residue (204)
      • modified residue (234)
      • modified residue (304)
    Domains in SCOP 1.75: d1foee1, d1foee2
  • Chain 'F':
    Compound: ras-related c3 botulinum toxin substrate
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1foef_
  • Chain 'G':
    Compound: t-lymphoma invasion and metastasis inducing protein 1
    Species: MUS MUSCULUS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q60610
      • modified residue (33)
      • modified residue (61)
      • modified residue (194)
      • modified residue (204)
      • modified residue (234)
      • modified residue (304)
    Domains in SCOP 1.75: d1foeg1, d1foeg2
  • Chain 'H':
    Compound: ras-related c3 botulinum toxin substrate
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1foeh_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1foeA (A:)
amgrqlsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnlt
emvefqveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcash
tkvpkvlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltda
eseehyhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlll
htsviwlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpf
rfrhmiptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflks
vhsilrdkhrrqllkte

    Sequence, based on observed residues (ATOM records): (download) 
    >1foeA (A:)
qlsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnltemve
fqveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcashtkvp
kvlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltdaesee
hyhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlllhtsv
iwlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpfrfrh
miptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflksvhsi
lrdkhrrq

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1foeB (B:)
mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1foeC (C:)
amgrqlsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnlt
emvefqveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcash
tkvpkvlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltda
eseehyhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlll
htsviwlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpf
rfrhmiptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflks
vhsilrdkhrrqllkte

    Sequence, based on observed residues (ATOM records): (download) 
    >1foeC (C:)
sdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnltemvefq
veflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcashtkvpkv
lvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltdaeseehy
hldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlllhtsviw
lnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpfrfrhmi
ptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflksvhsilr
dkhrrq

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1foeD (D:)
mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavl

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1foeE (E:)
amgrqlsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnlt
emvefqveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcash
tkvpkvlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltda
eseehyhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlll
htsviwlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpf
rfrhmiptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflks
vhsilrdkhrrqllkte

    Sequence, based on observed residues (ATOM records): (download) 
    >1foeE (E:)
lsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnltemvef
qveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcashtkvpk
vlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltdaeseeh
yhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlllhtsvi
wlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpfrfrhm
iptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflksvhsil
rdkhrrq

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1foeF (F:)
mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavl

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1foeG (G:)
amgrqlsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnlt
emvefqveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcash
tkvpkvlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltda
eseehyhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlll
htsviwlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpf
rfrhmiptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflks
vhsilrdkhrrqllkte

    Sequence, based on observed residues (ATOM records): (download) 
    >1foeG (G:)
lsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnltemvef
qveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcashtkvpk
vlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltdaeseeh
yhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlllhtsvi
wlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpfrfrhm
iptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflksvhsil
rdkhrrq

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1foeH (H:)
mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavl