PDB entry 1foe

View 1foe on RCSB PDB site
Description: crystal structure of rac1 in complex with the guanine nucleotide exchange region of tiam1
Class: signaling protein, immune system/signaling protein
Keywords: DBL HOMOLOGY DOMAIN, PLECKSTRIN HOMOLOGY DOMAIN, GTPASE, GUANINE NUCLEOTIDE EXCHANGE FACTOR, signaling protein, immune system/signaling protein COMPLEX
Deposited on 2000-08-27, released 2001-01-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.262
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: t-lymphoma invasion and metastasis inducing protein 1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q60610
      • modified residue (33)
      • modified residue (61)
      • modified residue (194)
      • modified residue (204)
      • modified residue (234)
      • modified residue (304)
    Domains in SCOPe 2.07: d1foea1, d1foea2
  • Chain 'B':
    Compound: ras-related c3 botulinum toxin substrate
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1foeb_
  • Chain 'C':
    Compound: t-lymphoma invasion and metastasis inducing protein 1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q60610
      • modified residue (33)
      • modified residue (61)
      • modified residue (194)
      • modified residue (204)
      • modified residue (234)
      • modified residue (304)
    Domains in SCOPe 2.07: d1foec1, d1foec2
  • Chain 'D':
    Compound: ras-related c3 botulinum toxin substrate
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1foed_
  • Chain 'E':
    Compound: t-lymphoma invasion and metastasis inducing protein 1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q60610
      • modified residue (33)
      • modified residue (61)
      • modified residue (194)
      • modified residue (204)
      • modified residue (234)
      • modified residue (304)
    Domains in SCOPe 2.07: d1foee1, d1foee2
  • Chain 'F':
    Compound: ras-related c3 botulinum toxin substrate
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1foef_
  • Chain 'G':
    Compound: t-lymphoma invasion and metastasis inducing protein 1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q60610
      • modified residue (33)
      • modified residue (61)
      • modified residue (194)
      • modified residue (204)
      • modified residue (234)
      • modified residue (304)
    Domains in SCOPe 2.07: d1foeg1, d1foeg2
  • Chain 'H':
    Compound: ras-related c3 botulinum toxin substrate
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1foeh_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1foeA (A:)
    amgrqlsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnlt
    emvefqveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcash
    tkvpkvlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltda
    eseehyhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlll
    htsviwlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpf
    rfrhmiptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflks
    vhsilrdkhrrqllkte
    

    Sequence, based on observed residues (ATOM records): (download)
    >1foeA (A:)
    qlsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnltemve
    fqveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcashtkvp
    kvlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltdaesee
    hyhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlllhtsv
    iwlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpfrfrh
    miptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflksvhsi
    lrdkhrrq
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1foeB (B:)
    mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
    qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
    ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavl
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1foeC (C:)
    amgrqlsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnlt
    emvefqveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcash
    tkvpkvlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltda
    eseehyhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlll
    htsviwlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpf
    rfrhmiptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflks
    vhsilrdkhrrqllkte
    

    Sequence, based on observed residues (ATOM records): (download)
    >1foeC (C:)
    sdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnltemvefq
    veflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcashtkvpkv
    lvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltdaeseehy
    hldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlllhtsviw
    lnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpfrfrhmi
    ptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflksvhsilr
    dkhrrq
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1foeD (D:)
    mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
    qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
    ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavl
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >1foeE (E:)
    amgrqlsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnlt
    emvefqveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcash
    tkvpkvlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltda
    eseehyhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlll
    htsviwlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpf
    rfrhmiptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflks
    vhsilrdkhrrqllkte
    

    Sequence, based on observed residues (ATOM records): (download)
    >1foeE (E:)
    lsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnltemvef
    qveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcashtkvpk
    vlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltdaeseeh
    yhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlllhtsvi
    wlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpfrfrhm
    iptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflksvhsil
    rdkhrrq
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1foeF (F:)
    mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
    qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
    ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavl
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >1foeG (G:)
    amgrqlsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnlt
    emvefqveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcash
    tkvpkvlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltda
    eseehyhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlll
    htsviwlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpf
    rfrhmiptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflks
    vhsilrdkhrrqllkte
    

    Sequence, based on observed residues (ATOM records): (download)
    >1foeG (G:)
    lsdadklrkvicelletertyvkdlnclmerylkplqketfltqdeldvlfgnltemvef
    qveflktledgvrlvpdleklekvdqfkkvlfslggsflyyadrfklysafcashtkvpk
    vlvkaktdtafkafldaqnprqqhsstlesylikpiqrvlkyplllrelfaltdaeseeh
    yhldvaiktmnkvashinemqkiheefgavfdqliaeqtgekkevadlsmgdlllhtsvi
    wlnppaslgkwkkepelaafvfktavvlvykdgskqkkklvgshrlsiyeewdpfrfrhm
    iptealqvralpsadaeanavceivhvksesegrpervfhlccsspesrkdflksvhsil
    rdkhrrq
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1foeH (H:)
    mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
    qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
    ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavl