PDB entry 1fdv

View 1fdv on RCSB PDB site
Description: human 17-beta-hydroxysteroid-dehydrogenase type 1 mutant h221l complexed with nad+
Class: dehydrogenase
Keywords: dehydrogenase, 17-beta-hydroxysteroid, mutant, nad
Deposited on 1998-01-15, released 1998-05-27
The last revision prior to the SCOP 1.75 freeze date was dated 1998-05-27, with a file datestamp of 2007-07-20.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.219
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 17-beta-hydroxysteroid dehydrogenase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14061 (0-End)
      • engineered (220)
    Domains in SCOP 1.75: d1fdva_
  • Chain 'B':
    Compound: 17-beta-hydroxysteroid dehydrogenase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14061 (0-End)
      • engineered (220)
    Domains in SCOP 1.75: d1fdvb_
  • Chain 'C':
    Compound: 17-beta-hydroxysteroid dehydrogenase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14061 (0-End)
      • engineered (220)
    Domains in SCOP 1.75: d1fdvc_
  • Chain 'D':
    Compound: 17-beta-hydroxysteroid dehydrogenase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14061 (0-End)
      • engineered (220)
    Domains in SCOP 1.75: d1fdvd_
  • Heterogens: SO4, NAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1fdvA (A:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylalskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfgdvpakaeagaeaggg
rgpgaedeagrsavgdpelgdppaapq

    Sequence, based on observed residues (ATOM records): (download) 
    >1fdvA (A:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylalskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1fdvB (B:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylalskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfgdvpakaeagaeaggg
rgpgaedeagrsavgdpelgdppaapq

    Sequence, based on observed residues (ATOM records): (download) 
    >1fdvB (B:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtevldrtdihtfhrfyqylalskqvfreaaqnpeevaevfltalrapkptl
ryftterflpllrmrlddpsgsnyvtamhrevfgd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1fdvC (C:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylalskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfgdvpakaeagaeaggg
rgpgaedeagrsavgdpelgdppaapq

    Sequence, based on observed residues (ATOM records): (download) 
    >1fdvC (C:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylalskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1fdvD (D:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylalskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfgdvpakaeagaeaggg
rgpgaedeagrsavgdpelgdppaapq

    Sequence, based on observed residues (ATOM records): (download) 
    >1fdvD (D:)
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtevldrtdihtfhrfyqylalskqvfreaaqnpeevaevfltalrapkptl
ryftterflpllrmrlddpsgsnyvtamhrevfgd