PDB entry 1fak

View 1fak on RCSB PDB site
Description: human tissue factor complexed with coagulation factor viia inhibited with a bpti-mutant
Class: blood clotting
Keywords: complex(serine protease/cofactor/ligand), blood coagulation, serine protease, complex, co-factor, receptor enzyme, inhibitor, gla, egf, complex (serine protease/cofactor/ligand), blood clotting
Deposited on 1998-12-28, released 1999-12-03
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.237
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: protein (blood coagulation factor viia)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1fakh_
  • Chain 'I':
    Compound: protein (5l15)
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00974 (0-54)
      • conflict (10)
      • conflict (14)
      • conflict (16-18)
      • conflict (33)
      • conflict (38)
      • conflict (45)
    Domains in SCOPe 2.05: d1faki_
  • Chain 'L':
    Compound: protein (blood coagulation factor viia)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1fakl1, d1fakl2, d1fakl3
  • Chain 'T':
    Compound: protein (soluble tissue factor)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1fakt1, d1fakt2
  • Heterogens: GLC, FUC, CA, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >1fakH (H:)
    ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
    lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
    lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
    sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
    seprpgvllrapfp
    

    Sequence, based on observed residues (ATOM records): (download)
    >1fakH (H:)
    ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
    lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
    lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkspniteymfcagysdg
    skdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmrsep
    rpgvllrapfp
    

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1fakI (I:)
    apdfcleppydgpcralhlryfynakaglcqtfyyggclakrnnfesaedcmrtc
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >1fakL (L:)
    anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
    ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
    ladgvsctptveypcgkipilekrnaskpqgr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1fakL (L:)
    rtklfwisysdgdqcasspcqnggsckdqlqsyicfclpafegrncethkddqlicvnen
    ggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilek
    

  • Chain 'T':
    Sequence, based on SEQRES records: (download)
    >1fakT (T:)
    ntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeiv
    kdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgtkvn
    vtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdkgen
    ycfsvqavipsrtvnrkstdspvecm
    

    Sequence, based on observed residues (ATOM records): (download)
    >1fakT (T:)
    tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
    dvkqtylarvfsypageplyenspeftpyletnlgqptiqsfeqkvnvtvedertlvrrn
    ntflslrdvfgkdliytlyywgkktaktntneflidvycfsvqavipsrtvnrkstdspv
    ecm