PDB entry 1f8i

View 1f8i on RCSB PDB site
Description: crystal structure of isocitrate lyase:nitropropionate:glyoxylate complex from mycobacterium tuberculosis
Class: lyase
Keywords: AlPHA-BETA Barrel, Swapped Helices, closed conformation, Structural Genomics, PSI, Protein Structure Initiative, TB Structural Genomics Consortium, TBSGC, LYASE
Deposited on 2000-06-30, released 2000-12-30
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.166
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: isocitrate lyase
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A5H3
      • insertion (1)
      • engineered (191)
    Domains in SCOPe 2.01: d1f8ia_
  • Chain 'B':
    Compound: isocitrate lyase
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A5H3
      • insertion (1)
      • engineered (191)
    Domains in SCOPe 2.01: d1f8ib_
  • Chain 'C':
    Compound: isocitrate lyase
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A5H3
      • insertion (1)
      • engineered (191)
    Domains in SCOPe 2.01: d1f8ic_
  • Chain 'D':
    Compound: isocitrate lyase
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A5H3
      • insertion (1)
      • engineered (191)
    Domains in SCOPe 2.01: d1f8id_
  • Heterogens: MG, GLV, SIN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1f8iA (A:)
masvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweq
lhdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpq
vvrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvags
hwedqlasekksghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlits
dvderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfse
avkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmf
dlaygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttalt
gsteegqfh

    Sequence, based on observed residues (ATOM records): (download) 
    >1f8iA (A:)
asvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweql
hdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqv
vrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagsh
wedqlasekksghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsd
vderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfsea
vkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfd
laygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltg
steegqf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1f8iB (B:)
masvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweq
lhdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpq
vvrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvags
hwedqlasekksghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlits
dvderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfse
avkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmf
dlaygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttalt
gsteegqfh

    Sequence, based on observed residues (ATOM records): (download) 
    >1f8iB (B:)
asvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweql
hdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqv
vrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagsh
wedqlasekksghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsd
vderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfsea
vkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfd
laygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltg
steegqf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1f8iC (C:)
masvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweq
lhdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpq
vvrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvags
hwedqlasekksghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlits
dvderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfse
avkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmf
dlaygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttalt
gsteegqfh

    Sequence, based on observed residues (ATOM records): (download) 
    >1f8iC (C:)
asvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweql
hdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqv
vrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagsh
wedqlasekksghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsd
vderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfsea
vkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfd
laygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltg
steegqf

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1f8iD (D:)
masvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweq
lhdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpq
vvrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvags
hwedqlasekksghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlits
dvderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfse
avkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmf
dlaygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttalt
gsteegqfh

    Sequence, based on observed residues (ATOM records): (download) 
    >1f8iD (D:)
asvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweql
hdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqv
vrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagsh
wedqlasekksghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsd
vderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfsea
vkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfd
laygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltg
steegqf