PDB entry 1f45

View 1f45 on RCSB PDB site
Description: human interleukin-12
Class: cytokine/cytpkine
Keywords: interleukin, cytokine
Deposited on 2000-06-07, released 2001-06-20
The last revision prior to the SCOP 1.75 freeze date was dated 2003-01-07, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.241
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-12 beta chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1f45a1, d1f45a2, d1f45a3
  • Chain 'B':
    Compound: interleukin-12 alpha chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29459 (Start-196)
      • engineered (190)
    Domains in SCOP 1.75: d1f45b_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1f45A (A:)
iwelkkdvyvveldwypdapgemvvltcdtpeedgitwtldqssevlgsgktltiqvkef
gdagqytchkggevlshsllllhkkedgiwstdilkdqkepknktflrceaknysgrftc
wwlttistdltfsvkssrgssdpqgvtcgaatlsaervrgdnkeyeysvecqedsacpaa
eeslpievmvdavhklkyenytssffirdiikpdppknlqlkplknsrqvevsweypdtw
stphsyfsltfcvqvqgkskrekkdrvftdktsatvicrknasisvraqdryyssswsew
asvpcs

    Sequence, based on observed residues (ATOM records): (download) 
    >1f45A (A:)
iwelkkdvyvveldwypdapgemvvltcdtpeedgitwtldqssevlgsgktltiqvkef
gdagqytcshsllllhkkedgiwstdilkdqkepknktflrceaknysgrftcwwlttis
tdltfsvkssrgssdpqgvtcgaatlsaeeyeysvecqedsacpaaeeslpievmvdavh
klkyenytssffirdiikpdppknlqlkplknsrqvevsweypdtwstphsyfsltfcvq
vqkdrvftdktsatvicrsisvraqdryyssswsewasvpcs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1f45B (B:)
rnlpvatpdpgmfpclhhsqnllravsnmlqkarqtlefypctseeidheditkdktstv
eaclpleltknesclnsretsfitngsclasrktsfmmalclssiyedlkmyqvefktmn
akllmdpkrqifldqnmlavidelmqalnfnsetvpqkssleepdfyktkiklcillhaf
riravtidrvmsylnas

    Sequence, based on observed residues (ATOM records): (download) 
    >1f45B (B:)
qnllravsnmlqkarqtlefypcstveaclpleltknesctsfitngssfmmalclssiy
edlkmyqvefktmnakllmdpkrqifldqnmlavidelmqalyktkiklcillhafrira
vtidrvmsylnas