PDB entry 1ezf

View 1ezf on RCSB PDB site
Description: crystal structure of human squalene synthase
Class: transferase
Keywords: isoprenoid synthase fold, all alpha-helix, TRANSFERASE
Deposited on 2000-05-10, released 2000-10-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-31, with a file datestamp of 2018-01-26.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: farnesyl-diphosphate farnesyltransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37268 (Start-339)
      • engineered (7)
    Domains in SCOPe 2.08: d1ezfa_
  • Chain 'B':
    Compound: farnesyl-diphosphate farnesyltransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37268 (Start-339)
      • engineered (3)
      • engineered (7)
    Domains in SCOPe 2.08: d1ezfb_
  • Chain 'C':
    Compound: farnesyl-diphosphate farnesyltransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37268 (Start-339)
      • engineered (7)
    Domains in SCOPe 2.08: d1ezfc_
  • Heterogens: IN0, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1ezfA (A:)
mdrnslsnslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisv
ekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrm
gigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglf
lqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhi
pdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatn
mpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn

    Sequence, based on observed residues (ATOM records): (download) 
    >1ezfA (A:)
nslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpll
hnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmaef
ldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktnii
rdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvityl
srlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkidatnmpavkaiiyqymeeiyh
ripdsdpsssktrqiistirtqn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1ezfB (B:)
mdrnslsnslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisv
ekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrm
gigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglf
lqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhi
pdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatn
mpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn

    Sequence, based on observed residues (ATOM records): (download) 
    >1ezfB (B:)
nslsnslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekk
vpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgig
maefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqk
tniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdv
itylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavatnmpavkaiiyqymeeiy
hripdsdpsssktrqiistirtqn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1ezfC (C:)
mdrnslsnslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisv
ekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrm
gigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglf
lqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhi
pdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatn
mpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn

    Sequence, based on observed residues (ATOM records): (download) 
    >1ezfC (C:)
nslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpll
hnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmaef
ldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktnii
rdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvityl
srlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavatnmpavkaiiyqymeeiyhrip
dsdpsssktrqiistirtqn