PDB entry 1efx

View 1efx on RCSB PDB site
Description: structure of a complex between the human natural killer cell receptor kir2dl2 and a class I MHC ligand hla-cw3
Class: immune system
Keywords: MHC, HLA, class I, KIR, NK cell receptor, Immunoglobulin fold, receptor/MHC complex, IMMUNE SYSTEM
Deposited on 2000-02-10, released 2000-06-14
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.231
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla-cw3 (heavy chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAA88088 (0-277)
    Domains in SCOPe 2.01: d1efxa1, d1efxa2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • see remark 999 (0)
    Domains in SCOPe 2.01: d1efxb_
  • Chain 'C':
    Compound: peptide from importin alpha-2
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: natural killer cell receptor kir2dl2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1efxd1, d1efxd2
  • Chain 'E':
    Compound: natural killer cell receptor kir2dl2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1efxe1, d1efxe2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1efxA (A:)
gshsmryfytavsrpgrgephfiavgyvddtqfvrfdsdaasprgeprapwveqegpeyw
dretqkykrqaqtdrvslrnlrgyynqseagshiiqrmygcdvgpdgrllrgydqyaydg
kdyialnedlrswtaadtaaqitqrkweaareaeqlrayleglcvewlrrylkngketlq
raehpkthvthhpvsdheatlrcwalgfypaeitltwqwdgedqtqdtelvetrpagdgt
fqkwaavvvpsgeeqrytchvqheglpepltlrwepss

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1efxB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1efxD (D:)
hegvhrkpsllahpgrlvkseetvilqcwsdvrfehfllhregkfkdtlhligehhdgvs
kanfsigpmmqdlagtyrcygsvthspyqlsapsdpldivitglyekpslsaqpgptvla
gesvtlscssrssydmyhlsregeahecrfsagpkvngtfqadfplgpathggtyrcfgs
frdspyewsnssdpllvsvi

    Sequence, based on observed residues (ATOM records): (download) 
    >1efxD (D:)
vhrkpsllahpgrlvkseetvilqcwsdvrfehfllhregkfkdtlhligehhdgvskan
fsigpmmqdlagtyrcygsvthspyqlsapsdpldivitglyekpslsaqpgptvlages
vtlscssrssydmyhlsregeahecrfsagpkvngtfqadfplgpathggtyrcfgsfrd
spyewsnssdpllvsvi

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1efxE (E:)
hegvhrkpsllahpgrlvkseetvilqcwsdvrfehfllhregkfkdtlhligehhdgvs
kanfsigpmmqdlagtyrcygsvthspyqlsapsdpldivitglyekpslsaqpgptvla
gesvtlscssrssydmyhlsregeahecrfsagpkvngtfqadfplgpathggtyrcfgs
frdspyewsnssdpllvsvi

    Sequence, based on observed residues (ATOM records): (download) 
    >1efxE (E:)
vhrkpsllahpgrlvkseetvilqcwsdvrfehfllhregkfkdtlhligehhdgvskan
fsigpmmqdlagtyrcygsvthspyqlsapsdpldivitglyekpslsaqpgptvlages
vtlscssrssydmyhlsregeahecrfsagpkvngtfqadfplgpathggtyrcfgsfrd
spyewsnssdpllvsvi