PDB entry 1efl

View 1efl on RCSB PDB site
Description: human malic enzyme in a quaternary complex with nad, mg, and tartronate
Class: oxidoreductase
Keywords: closed form, malic enzyme, complex, tartronate, OXIDOREDUCTASE
Deposited on 2000-02-09, released 2000-03-08
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.206
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: malic enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.05: d1efla1, d1efla2
  • Chain 'B':
    Compound: malic enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.05: d1eflb1, d1eflb2
  • Chain 'C':
    Compound: malic enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.05: d1eflc1, d1eflc2
  • Chain 'D':
    Compound: malic enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.05: d1efld1, d1efld2
  • Heterogens: MG, NAD, TTN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1eflA (A:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1eflA (A:)
ikekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtsple
kyiyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdr
ghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclp
vcidvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnh
nafrflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgia
nlivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfeda
vnilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegr
clfasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakalts
qltdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrs
eydsllpdvyewp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1eflB (B:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1eflB (B:)
ikekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtsple
kyiyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdr
ghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclp
vcidvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnh
nafrflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgia
nlivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfeda
vnilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegr
clfasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakalts
qltdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrs
eydsllpdvyewp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1eflC (C:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1eflC (C:)
ikekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtsple
kyiyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdr
ghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclp
vcidvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnh
nafrflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgia
nlivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfeda
vnilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegr
clfasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakalts
qltdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrs
eydsllpdvyewp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1eflD (D:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1eflD (D:)
ikekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtsple
kyiyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdr
ghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclp
vcidvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnh
nafrflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgia
nlivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfeda
vnilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegr
clfasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakalts
qltdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrs
eydsllpdvyewp