PDB entry 1eer

View 1eer on RCSB PDB site
Description: crystal structure of human erythropoietin complexed to its receptor at 1.9 angstroms
Class: complex (cytokine/receptor)
Keywords: erythropoietin, erythropoietin receptor, signal transduction, hematopoietic cytokine, cytokine receptor class 1, complex (cytokine/receptor)
Deposited on 1998-07-24, released 1999-10-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.242
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: erythropoietin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01588 (0-165)
      • engineered (23)
      • engineered (37)
      • engineered (82)
      • engineered (120-121)
    Domains in SCOPe 2.08: d1eera_
  • Chain 'B':
    Compound: erythropoietin receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19235
      • engineered (52)
      • engineered (164)
      • engineered (211)
    Domains in SCOPe 2.08: d1eerb1, d1eerb2
  • Chain 'C':
    Compound: erythropoietin receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19235
      • engineered (52)
      • engineered (164)
      • engineered (211)
    Domains in SCOPe 2.08: d1eerc1, d1eerc2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1eerA (A:)
apprlicdsrvlerylleakeaekittgcaehcslnekitvpdtkvnfyawkrmevgqqa
vevwqglallseavlrgqallvkssqpweplqlhvdkavsglrslttllralgaqkeais
nsdaasaaplrtitadtfrklfrvysnflrgklklytgeacrtgdr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1eerB (B:)
refpppnpdpkfeskaallaargpeellcfterledlvcfweeaasagvgpgqysfsyql
edepwklcrlhqaptargavrfwcslptadtssfvplelrvtaasgapryhrvihinevv
lldapvglvarladesghvvlrwlpppetpmtshiryevdvsagqgagsvqrveilegrt
ecvlsnlrgrtrytfavrarmaepsfggfwsewsepvslltpsdldp

    Sequence, based on observed residues (ATOM records): (download) 
    >1eerB (B:)
dpkfeskaallaargpeellcfterledlvcfweeaasagvgpgqysfsyqledepwklc
rlhqaptargavrfwcslptadtssfvplelrvtaasgapryhrvihinevvlldapvgl
varladesghvvlrwlpppetpmtshiryevdvsagqgagsvqrveilegrtecvlsnlr
grtrytfavrarmaepsfggfwsewsepvsllt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1eerC (C:)
refpppnpdpkfeskaallaargpeellcfterledlvcfweeaasagvgpgqysfsyql
edepwklcrlhqaptargavrfwcslptadtssfvplelrvtaasgapryhrvihinevv
lldapvglvarladesghvvlrwlpppetpmtshiryevdvsagqgagsvqrveilegrt
ecvlsnlrgrtrytfavrarmaepsfggfwsewsepvslltpsdldp

    Sequence, based on observed residues (ATOM records): (download) 
    >1eerC (C:)
dpkfeskaallaargpeellcfterledlvcfweeaasagvgpgqysfsyqledepwklc
rlhqaptargavrfwcslptadtssfvplelrvtaasgapryhrvihinevvlldapvgl
varladesghvvlrwlpppetpmtshiryevdvsagqgagsvqrveilegrtecvlsnlr
grtrytfavrarmaepsfggfwsewsepvsllt