PDB entry 1e4w

View 1e4w on RCSB PDB site
Description: crossreactive binding of a circularized peptide to an anti-TGFalpha antibody Fab-fragment
Class: immune system
Keywords: immune system, complex (antibody-antigen), cross-reactivity, protein-peptide recognition
Deposited on 2000-07-12, released 2001-07-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-09, with a file datestamp of 2019-10-04.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: tab2
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1E4W (0-212)
    Domains in SCOPe 2.08: d1e4wh1, d1e4wh2, d1e4wh3
  • Chain 'L':
    Compound: tab2
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1E4W (0-213)
    Domains in SCOPe 2.08: d1e4wl1, d1e4wl2
  • Chain 'P':
    Compound: cyclic peptide
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 1E4W (0-6)
  • Heterogens: NI, CL, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1e4wH (H:)
qvqlqqpgaelvkpgasvklsckasgftftnywmhwvkqrpgqglewigeilpsngrtny
nekfktkatltvdkssntaymqlssltsedsavyycarspsdywgqgttltvssakttap
svyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytlss
svtvtsstwpsqsitcnvahpasstkvdkkiep

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1e4wL (L:)
diqmtqtpsslsaslgdrvtiscrasqdishylnwfqqkpdgtvklliyytstlhsgvps
rfsgsgsgtdysltisnleeediafyfcqqggalpftfgsgtklaikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvldswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

  • Chain 'P':
    No sequence available.