PDB entry 1e2l

View 1e2l on RCSB PDB site
Description: kinetics and crystal structure of the wild-type and the engineered y101f mutant of herpes simplex virus type 1 thymidine kinase interacting with (north)-methanocarba-thymidine
Class: thymidine kinase
Keywords: thymidine kinase, antiviral drug, enzyme-prodrug gene therapy, x-ray structure, sugar ring pucker
Deposited on 2000-05-23, released 2000-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.21
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidine kinase
    Species: HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17) [TaxId:10299]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03176 (0-End)
      • engineered mutation (55)
    Domains in SCOPe 2.08: d1e2la_
  • Chain 'B':
    Compound: Thymidine kinase
    Species: HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17) [TaxId:10299]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03176 (0-End)
      • engineered mutation (55)
    Domains in SCOPe 2.08: d1e2lb_
  • Heterogens: SO4, TMC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1e2lA (A:)
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianifttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrhp
iaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpge
rldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphig
dtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlts
gmvqthvttpgsipticdlartfaremgean

    Sequence, based on observed residues (ATOM records): (download) 
    >1e2lA (A:)
mptllrvyidgphgmgkttttqlldivyvpepmtywrvlgasetianifttqhrldqgei
sagdaavvmtsaqitmgmpyavtdavlaphiggeagspppaltlifdrhpiaallcypaa
rylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpgerldlamlaai
rrvygllantvrylqcggswredwgqlsgprphigdtlftlfrapellapngdlynvfaw
aldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipticdlartfar
emge

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1e2lB (B:)
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianifttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrhp
iaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpge
rldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphig
dtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlts
gmvqthvttpgsipticdlartfaremgean

    Sequence, based on observed residues (ATOM records): (download) 
    >1e2lB (B:)
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianifttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsppaltlifdrhpiaal
lcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrldlamlaai
rrvygllantvrylqcggswredwgqlsgpqsnagprphigdtlftlfrapellapngdl
ynvfawaldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipticdl
artfaremge