PDB entry 1e2i

View 1e2i on RCSB PDB site
Description: the nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by x-ray crystallography
Class: transferase
Keywords: adenine analog, enzyme-prodrug gene therapy, nucleoside-binding, thymidine kinase, x-ray crystallography
Deposited on 2000-05-23, released 2000-11-06
The last revision prior to the SCOP 1.75 freeze date was dated 2000-11-06, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.222
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidine kinase
    Species: Human herpesvirus 1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1e2ia_
  • Chain 'B':
    Compound: Thymidine kinase
    Species: Human herpesvirus 1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1e2ib_
  • Heterogens: SO4, APS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1e2iA (A:)
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrhp
iaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpge
rldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphig
dtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlts
gmvqthvttpgsipticdlartfaremgean

    Sequence, based on observed residues (ATOM records): (download) 
    >1e2iA (A:)
mptllrvyidgphgmgktddivyvpepmtywrvlgasetianiyttqhrldqgeisagda
avvmtsaqitmgmpyavtdavlaphiggeagpppaltlifdrhpiaallcypaarylmgs
mtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpgerldlamlaairrvygl
lantvrylqcggswredwgqlsgtgprphigdtlftlfrapellapngdlynvfawaldv
lakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipticdlartfaremge

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1e2iB (B:)
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrhp
iaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpge
rldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphig
dtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlts
gmvqthvttpgsipticdlartfaremgean

    Sequence, based on observed residues (ATOM records): (download) 
    >1e2iB (B:)
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeahapppaltlifdrhpiaa
llcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrerldlaml
aairrvygllantvrylqcggswredwgqlsgpqsnagprphigdtlftlfrapellapn
gdlynvfawaldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipti
cdlartfaremge