PDB entry 1dwc
View 1dwc on RCSB PDB site
Description: crystallographic analysis at 3.0-angstroms resolution of the binding to human thrombin of four active site-directed inhibitors
Class: hydrolase(serine proteinase)
Keywords: hydrolase(serine proteinase)
Deposited on
1992-08-19, released
1994-01-31
The last revision prior to the SCOP 1.75 freeze date was dated
2003-04-01, with a file datestamp of
2007-07-06.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.15
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: alpha-thrombin (large subunit)
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d1dwc.1 - Chain 'I':
Compound: hirudin iiia
Species: Hirudo medicinalis
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: alpha-thrombin (small subunit)
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d1dwc.1 - Heterogens: MIT, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence, based on SEQRES records: (download)
>1dwcH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge
Sequence, based on observed residues (ATOM records): (download)
>1dwcH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfg
- Chain 'I':
No sequence available.
- Chain 'L':
Sequence, based on SEQRES records: (download)
>1dwcL (L:)
tfgsgeadcglrplfekksledkterellesyidgr
Sequence, based on observed residues (ATOM records): (download)
>1dwcL (L:)
eadcglrplfekksledkterellesyid