PDB entry 1dqa

View 1dqa on RCSB PDB site
Description: complex of the catalytic portion of human hmg-coa reductase with hmg, coa, and nadp+
Class: oxidoreductase
Keywords: oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph
Deposited on 1999-12-30, released 2000-03-08
The last revision prior to the SCOP 1.75 freeze date was dated 2000-03-08, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.168
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • mutation (63)
    Domains in SCOP 1.75: d1dqaa1, d1dqaa4
  • Chain 'B':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • mutation (63)
    Domains in SCOP 1.75: d1dqab1, d1dqab4
  • Chain 'C':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • mutation (63)
    Domains in SCOP 1.75: d1dqac1, d1dqac4
  • Chain 'D':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • mutation (63)
    Domains in SCOP 1.75: d1dqad1, d1dqad4
  • Heterogens: COA, MAH, NAP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1dqaA (A:)
    gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
    etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
    gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
    saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
    kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
    kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
    easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
    vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta
    

    Sequence, based on observed residues (ATOM records): (download)
    >1dqaA (A:)
    lsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynysl
    vmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggass
    rvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagr
    nlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwieg
    rgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiy
    iacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqml
    gvqgackdnpgenarqlarivcgtvmagelslmaalaaghlvkshmihn
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1dqaB (B:)
    gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
    etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
    gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
    saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
    kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
    kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
    easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
    vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta
    

    Sequence, based on observed residues (ATOM records): (download)
    >1dqaB (B:)
    lsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynysl
    vmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggass
    rvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagr
    nlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwieg
    rgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiy
    iacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqml
    gvqgackdnpgenarqlarivcgtvmagelslmaalaaghlvksh
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1dqaC (C:)
    gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
    etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
    gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
    saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
    kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
    kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
    easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
    vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta
    

    Sequence, based on observed residues (ATOM records): (download)
    >1dqaC (C:)
    iqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslvmgacc
    envigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladg
    mtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirf
    qsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvv
    ceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqd
    aaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgac
    kdnpgenarqlarivcgtvmagelslmaalaaghlvkshmihnr
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1dqaD (D:)
    gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
    etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
    gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
    saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
    kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
    kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
    easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
    vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta
    

    Sequence, based on observed residues (ATOM records): (download)
    >1dqaD (D:)
    paykletliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympi
    pvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrl
    pracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamg
    mnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakv
    vrevlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssn
    citlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenar
    qlarivcgtvmagelslmaalaaghlvkshmihnrs