PDB entry 1dq9

View 1dq9 on RCSB PDB site
Description: complex of catalytic portion of human hmg-coa reductase with hmg-coa
Class: oxidoreductase
Keywords: oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph
Deposited on 1999-12-30, released 2000-03-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-03-14, with a file datestamp of 2018-03-09.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered mutation (63)
    Domains in SCOPe 2.08: d1dq9a1, d1dq9a4
  • Chain 'B':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered mutation (63)
    Domains in SCOPe 2.08: d1dq9b1, d1dq9b4
  • Chain 'C':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered mutation (63)
    Domains in SCOPe 2.08: d1dq9c1, d1dq9c4
  • Chain 'D':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered mutation (63)
    Domains in SCOPe 2.08: d1dq9d1, d1dq9d4
  • Heterogens: HMG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1dq9A (A:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1dq9A (A:)
flsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynys
lvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggas
srvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiag
rnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwie
grgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtai
yiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqm
lgvqgackdnpgenarqlarivcgtvmagelslmaalaaghlvks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1dq9B (B:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1dq9B (B:)
kflsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdyny
slvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglggga
ssrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsia
grnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwi
egrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivta
iyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclq
mlgvqgackdnpgenarqlarivcgtvmagelslmaalaaghlvk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1dq9C (C:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1dq9C (C:)
kflsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdyny
slvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglggga
ssrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsia
grnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwi
egrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivta
iyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclq
mlgvqgackdnpgenarqlarivcgtvmagelslmaalaaghlvksh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1dq9D (D:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1dq9D (D:)
gnaekgakflsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqyl
pyrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcra
iglgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlq
klhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkk
paainwiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynah
aanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnll
pqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaaghlvks