PDB entry 1dq8

View 1dq8 on RCSB PDB site
Description: complex of the catalytic portion of human hmg-coa reductase with hmg and coa
Class: oxidoreductase
Keywords: oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph
Deposited on 1999-12-30, released 2000-03-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-03-14, with a file datestamp of 2018-03-09.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered mutation (63)
    Domains in SCOPe 2.08: d1dq8a1, d1dq8a4
  • Chain 'B':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered mutation (63)
    Domains in SCOPe 2.08: d1dq8b1, d1dq8b4
  • Chain 'C':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered mutation (63)
    Domains in SCOPe 2.08: d1dq8c1, d1dq8c4
  • Chain 'D':
    Compound: protein (hmg-coa reductase)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered mutation (63)
    Domains in SCOPe 2.08: d1dq8d1, d1dq8d4
  • Heterogens: COA, MAH, DTT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1dq8A (A:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1dq8A (A:)
preprpneeclqikflsdaeiiqlvnakhipaykletliethergvsirrqllskklsep
sslqylpyrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvast
nrgcraiglgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdsts
rfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgn
yctdkkpaainwiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsi
ggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvg
ggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaaghlv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1dq8B (B:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1dq8B (B:)
flsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynys
lvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggas
srvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiag
rnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwie
grgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtai
yiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqm
lgvqgackdnpgenarqlarivcgtvmagelslmaalaaghlvks

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1dq8C (C:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1dq8C (C:)
daeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslvm
gaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrv
ladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnl
yirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrg
ksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyia
cgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgv
qgackdnpgenarqlarivcgtvmagelslmaalaaghlvks

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1dq8D (D:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1dq8D (D:)
gakflsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdy
nyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgg
gassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhts
iagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaain
wiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaaniv
taiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqac
lqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaaghlvk