PDB entry 1dls

View 1dls on RCSB PDB site
Description: methotrexate-resistant variants of human dihydrofolate reductase with substitution of leucine 22: kinetics, crystallography and potential as selectable markers
Class: oxido-reductase
Keywords: oxido-reductase
Deposited on 1995-01-25, released 1995-04-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.156
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: dihydrofolate reductase
  Species: Homo sapiens [TaxId:9606]
  Gene: POTENTIAL
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00374 (0-185)
    • conflict (21)
  Domains in SCOPe 2.08: d1dlsa_
• Heterogens: NDP, MTX, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1dlsA (A:)
  vgslncivavsqnmgigkngdypwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
  peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
  ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
  vyeknd