PDB entry 1dia

View 1dia on RCSB PDB site
Description: human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with nadp and inhibitor ly249543
Class: oxidoreductase,hydrolase
Keywords: tetrahydrofolate, dehydrogenase, cyclohydrolase, nadp, inhibitor, rossmann fold, oxidoreductase, hydrolase
Deposited on 1999-11-29, released 2000-07-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-31, with a file datestamp of 2018-01-26.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: methylenetetrahydrofolate dehydrogenase/cyclohydrolase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1diaa1, d1diaa2
  • Chain 'B':
    Compound: methylenetetrahydrofolate dehydrogenase/cyclohydrolase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1diab1, d1diab2
  • Heterogens: NAP, L24, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1diaA (A:)
    mapaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaa
    eeigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiap
    ekdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgap
    mhdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginy
    vpddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrflekfkp
    gkwmiq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1diaA (A:)
    apaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaae
    eigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiape
    kdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapm
    hdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginyk
    vvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1diaB (B:)
    mapaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaa
    eeigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiap
    ekdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgap
    mhdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginy
    vpddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrflekfkp
    gkwmiq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1diaB (B:)
    apaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaae
    eigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiape
    kdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapm
    hdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginyv
    pddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle