PDB entry 1d6w

View 1d6w on RCSB PDB site
Description: structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at p1
Class: hydrolase/hydrolase inhibitor
Keywords: hydrolase, thrombin, thrombin inhibitor, hydrolase-hydrolase inhibitor complex
Deposited on 1999-10-15, released 2000-10-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-04, with a file datestamp of 2017-09-29.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: thrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1d6wa_
  • Chain 'I':
    Compound: decapeptide inhibitor
    Species: Hirudo medicinalis, synthetic [TaxId:6421]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NA, 00R, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1d6wA (A:)
adcglrplfekksledkterellesyidgrivegsdaeigmspwqvmlfrkspqellcga
slisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihpry
nwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwta
nvgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfv
mkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqf

    Sequence, based on observed residues (ATOM records): (download) 
    >1d6wA (A:)
adcglrplfekksledkterellesyidivegsdaeigmspwqvmlfrkspqellcgasl
isdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynw
renldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketgqpsv
lqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnnrw
yqmgivswgegcdrdgkygfythvfrlkkwiqkvidqf

  • Chain 'I':
    No sequence available.