PDB entry 1d4f

View 1d4f on RCSB PDB site
Description: crystal structure of recombinant rat-liver d244e mutant s-adenosylhomocysteine hydrolase
Class: hydrolase
Keywords: S-adenosylhomocysteine hydrolase, AdoHcyase, AdoHcy, Mutagenesis, X-ray crystal structure, Enzyme structure, HYDROLASE
Deposited on 2000-06-22, released 2001-01-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-04, with a file datestamp of 2018-03-29.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: s-adenosylhomocysteine hydrolase
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10760 (Start-430)
      • engineered (243)
    Domains in SCOPe 2.08: d1d4fa1, d1d4fa2
  • Chain 'B':
    Compound: s-adenosylhomocysteine hydrolase
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10760 (Start-430)
      • engineered (243)
    Domains in SCOPe 2.08: d1d4fb1, d1d4fb2
  • Chain 'C':
    Compound: s-adenosylhomocysteine hydrolase
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10760 (Start-430)
      • engineered (243)
    Domains in SCOPe 2.08: d1d4fc1, d1d4fc2
  • Chain 'D':
    Compound: s-adenosylhomocysteine hydrolase
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10760 (Start-430)
      • engineered (243)
    Domains in SCOPe 2.08: d1d4fd1, d1d4fd2
  • Heterogens: NAD, ADN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1d4fA (A:)
adklpykvadiglaawgrkaldiaenempglmrmremysaskplkgariagclhmtveta
vlietlvalgaevrwsscnifstqdhaaaaiakagipvfawkgetdeeylwcieqtlhfk
dgplnmilddggdltnlihtkhpqllsgirgiseetttgvhnlykmmangilkvpainvn
dsvtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarvii
teiepinalqaamegyevttmdeackegnifvtttgcvdiilgrhfeqmkddaivcnigh
fdveidvkwlnenavekvnikpqvdryllknghriillaegrlvnlgcamghpsfvmsns
ftnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgmpi
ngpfkpdhyry

    Sequence, based on observed residues (ATOM records): (download) 
    >1d4fA (A:)
dklpykvadiglaawgrkaldiaenempglmrmremysaskplkgariagclhmtvetav
lietlvalgaevrwsscnifstqdhaaaaiakagipvfawkgetdeeylwcieqtlhfkd
gplnmilddggdltnlihtkhpqllsgirgiseetttgvhnlykmmangilkvpainvnd
svtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarviit
eiepinalqaamegyevttmdeackegnifvtttgcvdiilgrhfeqmkddaivcnighf
dveidvkwlnenavekvnikpqvdryllknghriillaegrlvnlgcamghpsfvmsnsf
tnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgmpin
gpfkpdhyry

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1d4fB (B:)
adklpykvadiglaawgrkaldiaenempglmrmremysaskplkgariagclhmtveta
vlietlvalgaevrwsscnifstqdhaaaaiakagipvfawkgetdeeylwcieqtlhfk
dgplnmilddggdltnlihtkhpqllsgirgiseetttgvhnlykmmangilkvpainvn
dsvtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarvii
teiepinalqaamegyevttmdeackegnifvtttgcvdiilgrhfeqmkddaivcnigh
fdveidvkwlnenavekvnikpqvdryllknghriillaegrlvnlgcamghpsfvmsns
ftnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgmpi
ngpfkpdhyry

    Sequence, based on observed residues (ATOM records): (download) 
    >1d4fB (B:)
dklpykvadiglaawgrkaldiaenempglmrmremysaskplkgariagclhmtvetav
lietlvalgaevrwsscnifstqdhaaaaiakagipvfawkgetdeeylwcieqtlhfkd
gplnmilddggdltnlihtkhpqllsgirgiseetttgvhnlykmmangilkvpainvnd
svtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarviit
eiepinalqaamegyevttmdeackegnifvtttgcvdiilgrhfeqmkddaivcnighf
dveidvkwlnenavekvnikpqvdryllknghriillaegrlvnlgcamghpsfvmsnsf
tnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgmpin
gpfkpdhyry

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1d4fC (C:)
adklpykvadiglaawgrkaldiaenempglmrmremysaskplkgariagclhmtveta
vlietlvalgaevrwsscnifstqdhaaaaiakagipvfawkgetdeeylwcieqtlhfk
dgplnmilddggdltnlihtkhpqllsgirgiseetttgvhnlykmmangilkvpainvn
dsvtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarvii
teiepinalqaamegyevttmdeackegnifvtttgcvdiilgrhfeqmkddaivcnigh
fdveidvkwlnenavekvnikpqvdryllknghriillaegrlvnlgcamghpsfvmsns
ftnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgmpi
ngpfkpdhyry

    Sequence, based on observed residues (ATOM records): (download) 
    >1d4fC (C:)
dklpykvadiglaawgrkaldiaenempglmrmremysaskplkgariagclhmtvetav
lietlvalgaevrwsscnifstqdhaaaaiakagipvfawkgetdeeylwcieqtlhfkd
gplnmilddggdltnlihtkhpqllsgirgiseetttgvhnlykmmangilkvpainvnd
svtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarviit
eiepinalqaamegyevttmdeackegnifvtttgcvdiilgrhfeqmkddaivcnighf
dveidvkwlnenavekvnikpqvdryllknghriillaegrlvnlgcamghpsfvmsnsf
tnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgmpin
gpfkpdhyry

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1d4fD (D:)
adklpykvadiglaawgrkaldiaenempglmrmremysaskplkgariagclhmtveta
vlietlvalgaevrwsscnifstqdhaaaaiakagipvfawkgetdeeylwcieqtlhfk
dgplnmilddggdltnlihtkhpqllsgirgiseetttgvhnlykmmangilkvpainvn
dsvtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarvii
teiepinalqaamegyevttmdeackegnifvtttgcvdiilgrhfeqmkddaivcnigh
fdveidvkwlnenavekvnikpqvdryllknghriillaegrlvnlgcamghpsfvmsns
ftnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgmpi
ngpfkpdhyry

    Sequence, based on observed residues (ATOM records): (download) 
    >1d4fD (D:)
dklpykvadiglaawgrkaldiaenempglmrmremysaskplkgariagclhmtvetav
lietlvalgaevrwsscnifstqdhaaaaiakagipvfawkgetdeeylwcieqtlhfkd
gplnmilddggdltnlihtkhpqllsgirgiseetttgvhnlykmmangilkvpainvnd
svtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarviit
eiepinalqaamegyevttmdeackegnifvtttgcvdiilgrhfeqmkddaivcnighf
dveidvkwlnenavekvnikpqvdryllknghriillaegrlvnlgcamghpsfvmsnsf
tnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgmpin
gpfkpdhyry