PDB entry 1cz8
View 1cz8 on RCSB PDB site
Description: vascular endothelial growth factor in complex with an affinity matured antibody
Class: immune system
Keywords: complex (antibody-antigen), cystine knot, fab fragment, immune system
Deposited on
1999-09-01, released
2000-03-20
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-04-05, with a file datestamp of
2017-03-31.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.21
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: heavy chain of neutralizing antibody
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1cz8h1, d1cz8h2 - Chain 'L':
Compound: light chain of neutralizing antibody
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1cz8l1, d1cz8l2 - Chain 'V':
Compound: Vascular Endothelial Growth Factor A
Species: Homo sapiens [TaxId:9606]
Gene: VEGFA, VEGF
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1cz8v_ - Chain 'W':
Compound: Vascular Endothelial Growth Factor A
Species: Homo sapiens [TaxId:9606]
Gene: VEGFA, VEGF
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1cz8w_ - Chain 'X':
Compound: light chain of neutralizing antibody
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1cz8x1, d1cz8x2 - Chain 'Y':
Compound: heavy chain of neutralizing antibody
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1cz8y1, d1cz8y2 - Heterogens: SO4, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence, based on SEQRES records: (download)
>1cz8H (H:)
evqlvesggglvqpggslrlscaasgydfthygmnwvrqapgkglewvgwintytgepty
aadfkrrftfsldtskstaylqmnslraedtavyycakypyyygtshwyfdvwgqgtlvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthl
Sequence, based on observed residues (ATOM records): (download)
>1cz8H (H:)
evqlvesggglvqpggslrlscaasgydfthygmnwvrqapgkglewvgwintytgepty
aadfkrrftfsldtskstaylqmnslraedtavyycakypyyygtshwyfdvwgqgtlvt
vssastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
- Chain 'L':
Sequence, based on SEQRES records: (download)
>1cz8L (L:)
diqltqspsslsasvgdrvtitcsasqdisnylnwyqqkpgkapkvliyftsslhsgvps
rfsgsgsgtdftltisslqpedfatyycqqystvpwtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>1cz8L (L:)
diqltqspsslsasvgdrvtitcsasqdisnylnwyqqkpgkapkvliyftsslhsgvps
rfsgsgsgtdftltisslqpedfatyycqqystvpwtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge
- Chain 'V':
Sequence; same for both SEQRES and ATOM records: (download)
>1cz8V (V:)
vvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvptee
snitmqimrikphqgqhigemsflqhnkcecrpk
- Chain 'W':
Sequence; same for both SEQRES and ATOM records: (download)
>1cz8W (W:)
vvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvptee
snitmqimrikphqgqhigemsflqhnkcecrpk
- Chain 'X':
Sequence, based on SEQRES records: (download)
>1cz8X (X:)
diqltqspsslsasvgdrvtitcsasqdisnylnwyqqkpgkapkvliyftsslhsgvps
rfsgsgsgtdftltisslqpedfatyycqqystvpwtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>1cz8X (X:)
diqltqspsslsasvgdrvtitcsasqdisnylnwyqqkpgkapkvliyftsslhsgvps
rfsgsgsgtdftltisslqpedfatyycqqystvpwtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge
- Chain 'Y':
Sequence, based on SEQRES records: (download)
>1cz8Y (Y:)
evqlvesggglvqpggslrlscaasgydfthygmnwvrqapgkglewvgwintytgepty
aadfkrrftfsldtskstaylqmnslraedtavyycakypyyygtshwyfdvwgqgtlvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthl
Sequence, based on observed residues (ATOM records): (download)
>1cz8Y (Y:)
evqlvesggglvqpggslrlscaasgydfthygmnwvrqapgkglewvgwintytgepty
aadfkrrftfsldtskstaylqmnslraedtavyycakypyyygtshwyfdvwgqgtlvt
vssastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk