PDB entry 1cz8

View 1cz8 on RCSB PDB site
Description: vascular endothelial growth factor in complex with an affinity matured antibody
Class: immune system
Keywords: complex (antibody-antigen), cystine knot, fab fragment, immune system
Deposited on 1999-09-01, released 2000-03-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-04-05, with a file datestamp of 2017-03-31.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: heavy chain of neutralizing antibody
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1CZ8 (0-End)
    Domains in SCOPe 2.07: d1cz8h1, d1cz8h2
  • Chain 'L':
    Compound: light chain of neutralizing antibody
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1CZ8 (0-End)
    Domains in SCOPe 2.07: d1cz8l1, d1cz8l2
  • Chain 'V':
    Compound: Vascular Endothelial Growth Factor A
    Species: Homo sapiens [TaxId:9606]
    Gene: VEGFA, VEGF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1cz8v_
  • Chain 'W':
    Compound: Vascular Endothelial Growth Factor A
    Species: Homo sapiens [TaxId:9606]
    Gene: VEGFA, VEGF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1cz8w_
  • Chain 'X':
    Compound: light chain of neutralizing antibody
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1CZ8 (0-End)
    Domains in SCOPe 2.07: d1cz8x1, d1cz8x2
  • Chain 'Y':
    Compound: heavy chain of neutralizing antibody
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 1CZ8 (0-End)
    Domains in SCOPe 2.07: d1cz8y1, d1cz8y2
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >1cz8H (H:)
    evqlvesggglvqpggslrlscaasgydfthygmnwvrqapgkglewvgwintytgepty
    aadfkrrftfsldtskstaylqmnslraedtavyycakypyyygtshwyfdvwgqgtlvt
    vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
    qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1cz8H (H:)
    evqlvesggglvqpggslrlscaasgydfthygmnwvrqapgkglewvgwintytgepty
    aadfkrrftfsldtskstaylqmnslraedtavyycakypyyygtshwyfdvwgqgtlvt
    vssastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
    slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >1cz8L (L:)
    diqltqspsslsasvgdrvtitcsasqdisnylnwyqqkpgkapkvliyftsslhsgvps
    rfsgsgsgtdftltisslqpedfatyycqqystvpwtfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >1cz8L (L:)
    diqltqspsslsasvgdrvtitcsasqdisnylnwyqqkpgkapkvliyftsslhsgvps
    rfsgsgsgtdftltisslqpedfatyycqqystvpwtfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrge
    

  • Chain 'V':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1cz8V (V:)
    vvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvptee
    snitmqimrikphqgqhigemsflqhnkcecrpk
    

  • Chain 'W':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1cz8W (W:)
    vvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvptee
    snitmqimrikphqgqhigemsflqhnkcecrpk
    

  • Chain 'X':
    Sequence, based on SEQRES records: (download)
    >1cz8X (X:)
    diqltqspsslsasvgdrvtitcsasqdisnylnwyqqkpgkapkvliyftsslhsgvps
    rfsgsgsgtdftltisslqpedfatyycqqystvpwtfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >1cz8X (X:)
    diqltqspsslsasvgdrvtitcsasqdisnylnwyqqkpgkapkvliyftsslhsgvps
    rfsgsgsgtdftltisslqpedfatyycqqystvpwtfgqgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrge
    

  • Chain 'Y':
    Sequence, based on SEQRES records: (download)
    >1cz8Y (Y:)
    evqlvesggglvqpggslrlscaasgydfthygmnwvrqapgkglewvgwintytgepty
    aadfkrrftfsldtskstaylqmnslraedtavyycakypyyygtshwyfdvwgqgtlvt
    vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
    qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1cz8Y (Y:)
    evqlvesggglvqpggslrlscaasgydfthygmnwvrqapgkglewvgwintytgepty
    aadfkrrftfsldtskstaylqmnslraedtavyycakypyyygtshwyfdvwgqgtlvt
    vssastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
    slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk