PDB entry 1cwb

View 1cwb on RCSB PDB site
Description: the x-ray structure of (mebm2t)1-cyclosporin complexed with cyclophilin a provides an explanation for its anomalously high immunosuppressive activity
Class: complex (isomerase/immunosuppressant)
Keywords: complex (isomerase/immunosuppressant)
Deposited on 1995-09-06, released 1996-01-29
The last revision prior to the SCOP 1.75 freeze date was dated 1996-01-29, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.162
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: cyclophilin a
  Species: HOMO SAPIENS
  Gene: CYCLOPHILIN
  Database cross-references and differences (RAF-indexed):
  • Uniprot P05092 (1-164)
  Domains in SCOP 1.75: d1cwba_
• Chain 'C':
  Compound: [4-[(e)-2-butenyl]-4,4,n-trimethyl-l-threonine]1-cyclosporin
  
• Heterogens: HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1cwbA (A:)
  mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
  mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
  wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
  

  
  
• Chain 'C':
  No sequence available.