PDB entry 1cwb
View 1cwb on RCSB PDB site
Description: the x-ray structure of (mebm2t)1-cyclosporin complexed with cyclophilin a provides an explanation for its anomalously high immunosuppressive activity
Class: isomerase/immunosuppressant
Keywords: isomerase-immunosuppressant complex, cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, cyclophilin
Deposited on
1995-09-06, released
1996-01-29
The last revision prior to the SCOPe 2.08 freeze date was dated
2011-07-27, with a file datestamp of
2011-07-22.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.162
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Peptidyl-prolyl cis-trans isomerase A
Species: Homo sapiens [TaxId:9606]
Gene: CYCLOPHILIN
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1cwba_ - Chain 'C':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Heterogens: HOH