PDB entry 1cvs

View 1cvs on RCSB PDB site
Description: crystal structure of a dimeric fgf2-fgfr1 complex
Class: growth factor/growth factor receptor
Keywords: fgf, fgfr, immunoglobulin-like, signal transduction, dimerization, growth factor/growth factor receptor complex
Deposited on 1999-08-24, released 2000-01-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.24
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09038
      • engineered mutation (54)
      • engineered mutation (72)
    Domains in SCOPe 2.08: d1cvsa_
  • Chain 'B':
    Compound: fibroblast growth factor 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09038
      • engineered mutation (54)
      • engineered mutation (72)
    Domains in SCOPe 2.08: d1cvsb_
  • Chain 'C':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered mutation (44)
    Domains in SCOPe 2.08: d1cvsc1, d1cvsc2
  • Chain 'D':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered mutation (44)
    Domains in SCOPe 2.08: d1cvsd1, d1cvsd2
  • Heterogens: SO4

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1cvsA (A:)
ghfkdpkrlycknggfflrihpdgrvdgvreksdphiklqlqaeergvvsikgvsanryl
amkedgrllasksvtdecffferlesnnyntyrsrkytswyvalkrtgqyklgsktgpgq
kailflpmsaks

    Sequence, based on observed residues (ATOM records): (download) 
    >1cvsA (A:)
hfkdpkrlycknggfflrihpdgrvdgvreksdphiklqlqaeergvvsikgvsanryla
mkedgrllasksvtdecffferlesnnyntyrsrkytswyvalkrtgqyklgsktgpgqk
ailflpmsa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1cvsB (B:)
ghfkdpkrlycknggfflrihpdgrvdgvreksdphiklqlqaeergvvsikgvsanryl
amkedgrllasksvtdecffferlesnnyntyrsrkytswyvalkrtgqyklgsktgpgq
kailflpmsaks

    Sequence, based on observed residues (ATOM records): (download) 
    >1cvsB (B:)
hfkdpkrlycknggfflrihpdgrvdgvreksdphiklqlqaeergvvsikgvsanryla
mkedgrllasksvtdecffferlesnnyntyrsrkytswyvalkrtgqyklgsktgpgqk
ailflpmsa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1cvsC (C:)
tdntkpnrmpvapywtspekmekklhavpaaktvkfkcpssgtpqptlrwlkngkefkpd
hriggykvryatwsiimdsvvpsdkgnytciveneygsinhtyqldvversphrpilqag
lpanktvalgsnvefmckvysdpqphiqwlkhievngskigpdnlpyvqilktagvnttd
kemevlhlrnvsfedageytclagnsiglshhsawltvlealeer

    Sequence, based on observed residues (ATOM records): (download) 
    >1cvsC (C:)
mpvapywtspekmekklhavpaaktvkfkcpssgtpqptlrwlkngkefkpdhriggykv
ryatwsiimdsvvpsdkgnytciveneygsinhtyqldvversphrpilqaglpanktva
lgsnvefmckvysdpqphiqwlkhievngskigpdnlpyvqilktagvnttdkemevlhl
rnvsfedageytclagnsiglshhsawltvl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1cvsD (D:)
tdntkpnrmpvapywtspekmekklhavpaaktvkfkcpssgtpqptlrwlkngkefkpd
hriggykvryatwsiimdsvvpsdkgnytciveneygsinhtyqldvversphrpilqag
lpanktvalgsnvefmckvysdpqphiqwlkhievngskigpdnlpyvqilktagvnttd
kemevlhlrnvsfedageytclagnsiglshhsawltvlealeer

    Sequence, based on observed residues (ATOM records): (download) 
    >1cvsD (D:)
mpvapywtspekmekklhavpaaktvkfkcpssgtpqptlrwlkngkefkpdhriggykv
ryatwsiimdsvvpsdkgnytciveneygsinhtyqldvversphrpilqaglpanktva
lgsnvefmckvysdpqphiqwlkhvqilktagvnttdkemevlhlrnvsfedageytcla
gnsiglshhsawltvl