PDB entry 1cs4

View 1cs4 on RCSB PDB site
Description: complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with 2'-deoxy-adenosine 3'-monophosphate, pyrophosphate and mg
Class: lyase/lyase/signaling protein
Keywords: complex (lyase/hydrolase), hydrolase, signal transducing protein, cyclase, effector enzyme, lyase/hydrolase complex, lyase/lyase/signaling protein complex
Deposited on 1999-08-16, released 2001-01-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.216
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: type v adenylate cyclase
    Species: Canis lupus familiaris [TaxId:9615]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30803
      • engineered (120)
    Domains in SCOPe 2.08: d1cs4a_
  • Chain 'B':
    Compound: type II adenylate cyclase
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1cs4b_
  • Chain 'C':
    Compound: guanine nucleotide-binding protein g(s)
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1cs4c1, d1cs4c2
  • Heterogens: MG, CL, GSP, 101, FOK, MES, POP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1cs4A (A:)
mhhhhhhamemkadinakqedmmfhkiyiqkhdnvsilfadiegftslasqctaqelvmt
lnelfarfdklaaenhclrikilgdcyycvsglpearadhahccvemgmdmieaislvre
mtgvnvnmrvgihsgrvhcgvlglrkwqfdvwsndvtlanhmeaggkagrihitkatlsy
lngdyevepgcggernaylkehsietflilrctqkrkeekamiak

    Sequence, based on observed residues (ATOM records): (download) 
    >1cs4A (A:)
mmfhkiyiqkhdnvsilfadiegftslasqctaqelvmtlnelfarfdklaaenhclrik
ilgdcyycvsglpearadhahccvemgmdmieaislvremtgvnvnmrvgihsgrvhcgv
lglrkwqfdvwsndvtlanhmeaggkagrihitkatlsylngdyevepgcggernaylke
hsietflil

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1cs4B (B:)
rslkneelyhqsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskp
kfsgvekiktigstymaatglsaipsqehaqeperqymhigtmvefayalvgkldainkh
sfndfklrvginhgpviagvigaqkpqydiwgntvnvasrmdstgvldkiqvteetslil
qtlgytctcrgiinvkgkgdlktyfvntemsr

    Sequence, based on observed residues (ATOM records): (download) 
    >1cs4B (B:)
yhqsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskpkfsgveki
ktigstymaatglsairqymhigtmvefayalvgkldainkhsfndfklrvginhgpvia
gvigaqkpqydiwgntvnvasrmdstgvldkiqvteetslilqtlgytctcrgiinvkgk
gdlktyfvnt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1cs4C (C:)
mgclgnsktedqrneekaqreankkiekqlqkdkqvyrathrllllgagesgkstivkqm
rilhvngfngeggeedpqaarsnsdgekatkvqdiknnlkeaietivaamsnlvppvela
npenqfrvdyilsvmnvpdfdfppefyehakalwedegvracyersneyqlidcaqyfld
kidvikqddyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrkwiqcfnd
vtaiifvvasssynmvirednqtnrlqealnlfksiwnnrwlrtisvilflnkqdllaek
vlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgrhycy
phftcavdtenirrvfndcrdiiqrmhlrqyell

    Sequence, based on observed residues (ATOM records): (download) 
    >1cs4C (C:)
athrllllgagesgkstivkqmrilhvgekatkvqdiknnlkeaietivaamsnlvppve
lanpenqfrvdyilsvmnvpdfdfppefyehakalwedegvracyersneyqlidcaqyf
ldkidvikqddyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrkwiqcf
ndvtaiifvvasssynmvirednqtnrlqealnlfksiwnnrwlrtisvilflnkqdlla
ekvlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgrhy
cyphftcavdtenirrvfndcrdiiqrml