PDB entry 1cn4

View 1cn4 on RCSB PDB site
Description: erythropoietin complexed with extracellular domains of erythropoietin receptor
Class: hematopoietic cytokine
Keywords: hematopoietic cytokine, cytokine receptor
Deposited on 1999-05-25, released 1999-08-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-04, with a file datestamp of 2017-09-29.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (erythropoietin receptor)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19235
      • engineered (54)
      • engineered (166)
      • engineered (213)
    Domains in SCOPe 2.08: d1cn4a1, d1cn4a2
  • Chain 'B':
    Compound: protein (erythropoietin receptor)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19235 (Start-227)
      • engineered (54)
      • engineered (166)
      • engineered (213)
    Domains in SCOPe 2.08: d1cn4b1, d1cn4b2
  • Chain 'C':
    Compound: protein (erythropoietin)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01588
      • engineered (23)
      • engineered (37)
      • engineered (82)
    Domains in SCOPe 2.08: d1cn4c_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1cn4A (A:)
refapppnlpdpkfeskaallaargpeellcfterledlvcfweeaasagvgpgqysfsy
qledepwklcrlhqaptargavrfwcslptadtssfvplelrvtaasgapryhrvihine
vvlldapvglvarladesghvvlrwlpppetpmtshiryevdvsagqgagsvqrveileg
rtecvlsnlrgrtrytfavrarmaepsfggfwsewsepvslltpsdld

    Sequence, based on observed residues (ATOM records): (download) 
    >1cn4A (A:)
pdpkfeskaallaargpeellcfterledlvcfweeaasagvgpgqysfsyqledepwkl
crlhqaptargavrfwcslptadtssfvplelrvtaasgapryhrvihinevvlldapvg
lvarladesghvvlrwlpppetpmtshiryevdvsagqgagsvqrveilegrtecvlsnl
rgrtrytfavrarmaepsfggfwsewsepvslltpsd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1cn4B (B:)
refapppnlpdpkfeskaallaargpeellcfterledlvcfweeaasagvgpgqysfsy
qledepwklcrlhqaptargavrfwcslptadtssfvplelrvtaasgapryhrvihine
vvlldapvglvarladesghvvlrwlpppetpmtshiryevdvsagqgagsvqrveileg
rtecvlsnlrgrtrytfavrarmaepsfggfwsewsepvslltpsdld

    Sequence, based on observed residues (ATOM records): (download) 
    >1cn4B (B:)
dpkfeskaallaargpeellcfterledlvcfweeaasagvgpgqysfsyqledepwklc
rlhqaptargavrfwcslptadtssfvplelrvtaasgapryhrvihinevvlldapvgl
varladesghvvlrwlpppetpmtshiryevdvsagqgagsvqrveilegrtecvlsnlr
grtrytfavrarmaepsfggfwsewsepvslltpsdld

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1cn4C (C:)
apprlicdsrvlerylleakeaekittgcaehcslnekitvpdtkvnfyawkrmevgqqa
vevwqglallseavlrgqallvkssqpweplqlhvdkavsglrslttllralgaqkeais
ppdaasaaplrtitadtfrklfrvysnflrgklklytgeacrtgdr

    Sequence, based on observed residues (ATOM records): (download) 
    >1cn4C (C:)
pprlicdsrvlerylleakeaekittgcaehcslnekitvpdtkvnfyawkrmevgqqav
evwqglallseavlrgqallvkssqpweplqlhvdkavsglrslttllralgaqkeaisp
pdrtitadtfrklfrvysnflrgklklytgeacr