PDB entry 1ceq

View 1ceq on RCSB PDB site
Description: chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase.
Class: oxidoreductase
Keywords: oxidoreductase, tricarboxylic acid cycle, inhibitor
Deposited on 1999-03-10, released 1999-03-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.19
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (l-lactate dehydrogenase)
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q27743 (Start-315)
      • conflict (72)
    Domains in SCOPe 2.08: d1ceqa1, d1ceqa2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1ceqA (A:)
mapkakivlvgsgmiggvmatlivqknlgdvvlfdivknmphgkaldtshtnvmaysnck
vsgsntyddlagsdvvivtagftkapgksdkewnrddllplnnkimieigghikkncpna
fiivvtnpvdvmvqllhqhsgvpknkiiglggvldtsrlkyyisqklnvcprdvnahivg
ahgnkmvllkryitvggiplqefinnklisdaeleaifdrtvntaleivnlhaspyvapa
aaiiemaesylkdlkkvlicstllegqyghsdifggtpvvlgangveqvielqlnseeka
kfdeaiaetkrmkala

    Sequence, based on observed residues (ATOM records): (download) 
    >1ceqA (A:)
pkakivlvgsgmiggvmatlivqknlgdvvlfdivknmphgkaldtshtnvmaysnckvs
gsntyddlagsdvvivtagftnrddllplnnkimieigghikkncpnafiivvtnpvdvm
vqllhqhsgvpknkiiglggvldtsrlkyyisqklnvcprdvnahivgahgnkmvllkry
itvggiplqefinnklisdaeleaifdrtvntaleivnlhaspyvapaaaiiemaesylk
dlkkvlicstllegqyghsdifggtpvvlgangveqvielqlnseekakfdeaiaetkrm
kala