PDB entry 1ca8

View 1ca8 on RCSB PDB site
Description: Thrombin inhibitors with rigid tripeptidyl aldehydes
Class: hydrolase/hydrolase inhibitor
Keywords: SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 1998-04-27, released 1999-04-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-27, with a file datestamp of 2011-07-22.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.157
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thrombin light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1ca8.1
  • Chain 'B':
    Compound: Thrombin heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1ca8.1
  • Chain 'C':
    Compound: hirugen
    Species: Hirudo medicinalis [TaxId:6421]
    Database cross-references and differences (RAF-indexed):
    • PDB 1CA8
  • Heterogens: NA, 0KV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1ca8A (A:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >1ca8A (A:)
adcglrplfekksledkterellesy

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1ca8B (B:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1ca8B (B:)
ivegsdaeigmspwqvmlfrkpqellcgaslisdrwvltaahcllyppwdknftendllv
rigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvclp
dretaasllqagykgrvtgwgnlketqpsvlqvvnlpiverpvckdstriritdnmfcag
ykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkw
iqkvidqfg

  • Chain 'C':
    No sequence available.