PDB entry 1c70

View 1c70 on RCSB PDB site
Description: alternate binding site for the p1-p3 group of a class of potent hiv-1 protease inhibitors as a result of concerted structural change in 80's loop.
Class: hydrolase
Keywords: hydrolase
Deposited on 1999-12-29, released 2000-12-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.16
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: protein (protease)
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: NY5 ISOLATE
  Database cross-references and differences (RAF-indexed):
  • Uniprot O92103
  Domains in SCOPe 2.08: d1c70a_
• Chain 'B':
  Compound: protein (protease)
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: NY5 ISOLATE
  Database cross-references and differences (RAF-indexed):
  • Uniprot O92103 (0-98)
  Domains in SCOPe 2.08: d1c70b_
• Heterogens: L75, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1c70A (A:)
  pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
  qilieicghkaigtvlvgptpvniigrnlltqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1c70B (B:)
  pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
  qilieicghkaigtvlvgptpvniigrnlltqigctlnf