PDB entry 1c6z

View 1c6z on RCSB PDB site
Description: alternate binding site for the p1-p3 group of a class of potent hiv-1 protease inhibitors as a result of concerted structural change in 80's loop.
Class: hydrolase/hydrolase inhibitor
Keywords: hydrolase-hydrolase inhibitor complex
Deposited on 1999-12-28, released 2000-12-28
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.18
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: protein (protease)
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: NY5 ISOLATE
  Database cross-references and differences (RAF-indexed):
  • Uniprot O09893
  Domains in SCOPe 2.01: d1c6za_
• Chain 'B':
  Compound: protein (protease)
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: NY5 ISOLATE
  Database cross-references and differences (RAF-indexed):
  • Uniprot O09893 (0-98)
  Domains in SCOPe 2.01: d1c6zb_
• Heterogens: ROC, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1c6zA (A:)
  pqitlwqrpvvtikiggqlmealidtgaddtvleemdlpgrwkpkiiggiggfvkvrqyd
  qipieicghkvigtvlvgptptniigrnlltqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1c6zB (B:)
  pqitlwqrpvvtikiggqlmealidtgaddtvleemdlpgrwkpkiiggiggfvkvrqyd
  qipieicghkvigtvlvgptptniigrnlltqigctlnf