PDB entry 1c5m
View 1c5m on RCSB PDB site
Description: structural basis for selectivity of a small molecule, s1-binding, sub-micromolar inhibitor of urokinase type plasminogen activator
Class: blood clotting
Keywords: selective, S1 site inhibitor, structure-based drug design, urokinase, trypsin, thrombin, BLOOD CLOTTING
Deposited on
1999-12-22, released
2000-12-22
The last revision prior to the SCOPe 2.07 freeze date was dated
2017-10-04, with a file datestamp of
2017-09-29.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.3
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'D':
Compound: protein (coagulation factor x)
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1c5md_ - Chain 'F':
Compound: protein (coagulation factor x)
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1c5mf_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'D':
Sequence, based on SEQRES records: (download)
>1c5mD (D:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
kshapevvitssplk
Sequence, based on observed residues (ATOM records): (download)
>1c5mD (D:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
k
- Chain 'F':
Sequence, based on SEQRES records: (download)
>1c5mF (F:)
ykdgdqcetspcqnqgkckdglgeytctclegfegkncelftrklcsldngdcdqfchee
qnsvvcscargytladngkaciptgpypcgkqtler
Sequence, based on observed residues (ATOM records): (download)
>1c5mF (F:)
lcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtler