PDB entry 1c5m

View 1c5m on RCSB PDB site
Description: structural basis for selectivity of a small molecule, s1-binding, sub-micromolar inhibitor of urokinase type plasminogen activator
Class: blood clotting
Keywords: selective, S1 site inhibitor, structure-based drug design, urokinase, trypsin, thrombin
Deposited on 1999-12-22, released 2000-12-22
The last revision prior to the SCOP 1.73 freeze date was dated 2001-09-26, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.218
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'D':
    Compound: protein (coagulation factor x)
    Species: HOMO SAPIENS
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1c5md_
  • Chain 'F':
    Compound: protein (coagulation factor x)
    Species: HOMO SAPIENS
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1c5mf_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1c5mD (D:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
    kshapevvitssplk
    

    Sequence, based on observed residues (ATOM records): (download)
    >1c5mD (D:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
    k
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >1c5mF (F:)
    ykdgdqcetspcqnqgkckdglgeytctclegfegkncelftrklcsldngdcdqfchee
    qnsvvcscargytladngkaciptgpypcgkqtler
    

    Sequence, based on observed residues (ATOM records): (download)
    >1c5mF (F:)
    lcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtler