PDB entry 1c4z

View 1c4z on RCSB PDB site
Description: structure of e6ap: insights into ubiquitination pathway
Class: ligase
Keywords: bilobal structure, elongated shape, e3 ubiquitin ligase, e2 ubiquitin conjugating enzyme
Deposited on 1999-10-14, released 1999-11-17
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.237
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ubiquitin-protein ligase e3a
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1c4za_
  • Chain 'B':
    Compound: ubiquitin-protein ligase e3a
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1c4zb_
  • Chain 'C':
    Compound: ubiquitin-protein ligase e3a
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1c4zc_
  • Chain 'D':
    Compound: ubiquitin conjugating enzyme e2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1c4zd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1c4zA (A:)
    qlnpylrlkvrrdhiiddalvrlemiamenpadlkkqlyvefegeqgvdeggvskeffql
    vveeifnpdigmftydestklfwfnpssfetegqftligivlglaiynncildvhfpmvv
    yrklmgkkgtfrdlgdshpvlyqslkdlleyegnveddmmitfqisqtdlfgnpmmydlk
    engdkipitnenrkefvnlysdyilnksvekqfkafrrgfhmvtnesplkylfrpeeiel
    licgsrnldfqaleetteydggytrdsvlirefweivhsftdeqkrlflqfttgtdrapv
    gglgklkmiiakngpdterlptshtcfnvlllpeysskeklkerllkaityakgfgml
    

    Sequence, based on observed residues (ATOM records): (download)
    >1c4zA (A:)
    npylrlkvrrdhiiddalvrlemiamenpadlkkqlyvefegeqgvdeggvskeffqlvv
    eeifnpdigmftydestklfwfnpssfetegqftligivlglaiynncildvhfpmvvyr
    klmgkkgtfrdlgdshpvlyqslkdlleyegnveddmmitfqisqtdlfgnpmmydlken
    gdkipitnenrkefvnlysdyilnksvekqfkafrrgfhmvtnesplkylfrpeeielli
    cgsrnldfqaleetteydggytrdsvlirefweivhsftdeqkrlflqfttgtdrapvgg
    lgklkmiiakngpdterlptshtcfnvlllpeysskeklkerllkaitya
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1c4zB (B:)
    qlnpylrlkvrrdhiiddalvrlemiamenpadlkkqlyvefegeqgvdeggvskeffql
    vveeifnpdigmftydestklfwfnpssfetegqftligivlglaiynncildvhfpmvv
    yrklmgkkgtfrdlgdshpvlyqslkdlleyegnveddmmitfqisqtdlfgnpmmydlk
    engdkipitnenrkefvnlysdyilnksvekqfkafrrgfhmvtnesplkylfrpeeiel
    licgsrnldfqaleetteydggytrdsvlirefweivhsftdeqkrlflqfttgtdrapv
    gglgklkmiiakngpdterlptshtcfnvlllpeysskeklkerllkaityakgfgml
    

    Sequence, based on observed residues (ATOM records): (download)
    >1c4zB (B:)
    npylrlkvrrdhiiddalvrlemiamenpadlkkqlyvefegeqgvdeggvskeffqlvv
    eeifnpdigmftydestklfwfnpssfetegqftligivlglaiynncildvhfpmvvyr
    klmgkkgtfrdlgdshpvlyqslkdlleyegnveddmmitfqisqtdlfgnpmmydlken
    gdkipitnenrkefvnlysdyilnksvekqfkafrrgfhmvtnesplkylfrpeeielli
    cgsrnldfqaleetteydggytrdsvlirefweivhsftdeqkrlflqfttgtdrapvgg
    lgklkmiiakngpdterlptshtcfnvlllpeysskeklkerllkaitya
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1c4zC (C:)
    qlnpylrlkvrrdhiiddalvrlemiamenpadlkkqlyvefegeqgvdeggvskeffql
    vveeifnpdigmftydestklfwfnpssfetegqftligivlglaiynncildvhfpmvv
    yrklmgkkgtfrdlgdshpvlyqslkdlleyegnveddmmitfqisqtdlfgnpmmydlk
    engdkipitnenrkefvnlysdyilnksvekqfkafrrgfhmvtnesplkylfrpeeiel
    licgsrnldfqaleetteydggytrdsvlirefweivhsftdeqkrlflqfttgtdrapv
    gglgklkmiiakngpdterlptshtcfnvlllpeysskeklkerllkaityakgfgml
    

    Sequence, based on observed residues (ATOM records): (download)
    >1c4zC (C:)
    npylrlkvrrdhiiddalvrlemiamenpadlkkqlyvefegeqgvdeggvskeffqlvv
    eeifnpdigmftydestklfwfnpssfetegqftligivlglaiynncildvhfpmvvyr
    klmgkkgtfrdlgdshpvlyqslkdlleyegnveddmmitfqisqtdlfgnpmmydlken
    gdkipitnenrkefvnlysdyilnksvekqfkafrrgfhmvtnesplkylfrpeeielli
    cgsrnldfqaleetteydggytrdsvlirefweivhsftdeqkrlflqfttgtdrapvgg
    lgklkmiiakngpdterlptshtcfnvlllpeysskeklkerllkaitya
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1c4zD (D:)
    maasrrlmkeleeirkcgmknfrniqvdeanlltwqglivpdnppydkgafrieinfpae
    ypfkppkitfktkiyhpnidekgqvclpvisaenwkpatktdqviqslialvndpqpehp
    lradlaeeyskdrkkfcknaeeftkkygekrpvd
    

    Sequence, based on observed residues (ATOM records): (download)
    >1c4zD (D:)
    srrlmkeleeirkcgmknfrniqvdeanlltwqglivpdnppydkgafrieinfpaeypf
    kppkitfktkiyhpnidekgqvclpvisaenwkpatktdqviqslialvndpqpehplra
    dlaeeyskdrkkfcknaeeftkky