PDB entry 1c4u

View 1c4u on RCSB PDB site
Description: selective non electrophilic thrombin inhibitors with cyclohexyl moieties.
Class: hydrolase/hydrolase inhibitor
Keywords: complex (serine protease-inhibitor), hydrolase, hydrolase-hydrolase inhibitor complex
Deposited on 1999-09-25, released 2000-09-27
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.167
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain '1':
    Compound: thrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1c4u.1
  • Chain '2':
    Compound: thrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1c4u.1
  • Chain '3':
    Compound: protein (hirugen)
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28504 (Start-13)
      • conflict (8)
      • conflict (11)
  • Heterogens: NA, IH1, HOH

PDB Chain Sequences:

  • Chain '1':
    Sequence, based on SEQRES records: (download) 
    >1c4u1 (1:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >1c4u1 (1:)
sgeadcglrplfekksledkterellesyi

  • Chain '2':
    Sequence, based on SEQRES records: (download) 
    >1c4u2 (2:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1c4u2 (2:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketgqpsvlqvvnlpiverpvckdstriritdnmfc
agykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlk
kwiqkvidqfge

  • Chain '3':
    No sequence available.