PDB entry 1br8

View 1br8 on RCSB PDB site
Description: implications for function and therapy of a 2.9a structure of binary-complexed antithrombin
Class: blood clotting
Keywords: serpins, antithrombin, binary-complex, crystal structure, heparin, polymerisation, thrombosis, emphysema, cirrhosis
Deposited on 1998-08-26, released 1998-09-02
The last revision prior to the SCOP 1.73 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.23
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'I':
    Compound: protein (antithrombin-III)
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1br8i_
  • Chain 'L':
    Compound: protein (antithrombin-III)
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1br8l_
  • Chain 'P':
    Compound: protein (peptide)
    Species: synthetic, synthetic
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >1br8I (I:)
    hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
    tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
    fffaklncrlyrkankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
    qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
    kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
    pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
    dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
    ifmgrvanpcvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >1br8I (I:)
    ictakprdipmnpmciyrspetnrrvwelskansrfattfyqhladskndndniflspls
    istafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkankssklvs
    anrlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnktegritdvi
    pseaineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqegkfryrr
    vaegtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemmlvvhmpr
    friedgfslkeqlqdmglvdlfspeksklpgivaegrddlyvsdafhkaflevneeasta
    vviagrslnpnrvtfkanrpflvfirevplntiifmgrvanpcv
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >1br8L (L:)
    hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
    tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
    fffaklncrlyrkankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
    qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
    kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
    pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
    dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
    ifmgrvanpcvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >1br8L (L:)
    ctakprdipmnpmciyrsatnrrvwelskansrfattfyqhladskndndniflsplsis
    tafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkankssklvsan
    rlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnktegritdvips
    eaineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqegkfryrrva
    egtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemmlvvhmprfr
    iedgfslkeqlqdmglvdlfspeksklpgivaegrddlyvsdafhkaflevneegseaaa
    stavviagrslnrpflvfirevplntiifmgrvanpcv
    

  • Chain 'P':
    No sequence available.