PDB entry 1br8

View 1br8 on RCSB PDB site
Description: implications for function and therapy of a 2.9a structure of binary-complexed antithrombin
Class: blood clotting
Keywords: serpins, antithrombin, binary-complex, crystal structure, heparin, polymerisation, thrombosis, emphysema, cirrhosis, blood clotting
Deposited on 1998-08-26, released 1998-09-02
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.23
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'I':
    Compound: protein (antithrombin-III)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1br8i_
  • Chain 'L':
    Compound: protein (antithrombin-III)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1br8l_
  • Chain 'P':
    Compound: protein (peptide)
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1BR8 (0-11)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >1br8I (I:)
    hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
    tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
    fffaklncrlyrkankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
    qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
    kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
    pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
    dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
    ifmgrvanpcvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >1br8I (I:)
    ictakprdipmnpmciyrspetnrrvwelskansrfattfyqhladskndndniflspls
    istafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkankssklvs
    anrlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnktegritdvi
    pseaineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqegkfryrr
    vaegtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemmlvvhmpr
    friedgfslkeqlqdmglvdlfspeksklpgivaegrddlyvsdafhkaflevneeasta
    vviagrslnpnrvtfkanrpflvfirevplntiifmgrvanpcv
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >1br8L (L:)
    hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
    tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
    fffaklncrlyrkankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
    qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
    kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
    pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
    dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
    ifmgrvanpcvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >1br8L (L:)
    ctakprdipmnpmciyrsatnrrvwelskansrfattfyqhladskndndniflsplsis
    tafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkankssklvsan
    rlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnktegritdvips
    eaineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqegkfryrrva
    egtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemmlvvhmprfr
    iedgfslkeqlqdmglvdlfspeksklpgivaegrddlyvsdafhkaflevneegseaaa
    stavviagrslnrpflvfirevplntiifmgrvanpcv
    

  • Chain 'P':
    No sequence available.