PDB entry 1boz
View 1boz on RCSB PDB site
Description: structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductase and potential antitumor agents
Class: oxidoreductase
Keywords: oxidoreductase
Deposited on
1998-08-06, released
1998-08-12
The last revision prior to the SCOP 1.75 freeze date was dated
2000-05-05, with a file datestamp of
2007-06-04.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.202
AEROSPACI score: 0.45
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: protein (dihydrofolate reductase)
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d1boza_ - Heterogens: NDP, PRD, HOH