PDB entry 1a81

View 1a81 on RCSB PDB site
Description: crystal structure of the tandem sh2 domain of the syk kinase bound to a dually tyrosine-phosphorylated itam
Class: complex (transferase/peptide)
Keywords: COMPLEX (TRANSFERASE-PEPTIDE), SYK, KINASE, SH2 DOMAIN, ITAM, COMPLEX (TRANSFERASE-PEPTIDE) complex
Deposited on 1998-03-31, released 1998-10-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-05-25, with a file datestamp of 2016-05-20.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: syk kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1a81a1, d1a81a2
  • Chain 'B':
    Compound: T-cell surface glycoprotein CD3 epsilon chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07766 (0-17)
      • conflict (2)
      • conflict (13)
      • modified residue (2)
      • modified residue (13)
  • Chain 'C':
    Compound: syk kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1a81c1, d1a81c2
  • Chain 'D':
    Compound: T-cell surface glycoprotein CD3 epsilon chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07766 (0-17)
      • conflict (2)
      • conflict (13)
      • modified residue (2)
      • modified residue (13)
  • Chain 'E':
    Compound: syk kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1a81e1, d1a81e2
  • Chain 'F':
    Compound: T-cell surface glycoprotein CD3 epsilon chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07766 (0-17)
      • conflict (2)
      • conflict (13)
      • modified residue (2)
      • modified residue (13)
  • Chain 'G':
    Compound: syk kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1a81g1, d1a81g2
  • Chain 'H':
    Compound: T-cell surface glycoprotein CD3 epsilon chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07766 (0-17)
      • conflict (2)
      • conflict (13)
      • modified residue (2)
      • modified residue (13)
  • Chain 'I':
    Compound: syk kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1a81i1, d1a81i2
  • Chain 'J':
    Compound: T-cell surface glycoprotein CD3 epsilon chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07766 (0-17)
      • conflict (2)
      • conflict (13)
      • modified residue (2)
      • modified residue (13)
  • Chain 'K':
    Compound: syk kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1a81k1, d1a81k2
  • Chain 'L':
    Compound: T-cell surface glycoprotein CD3 epsilon chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07766 (0-17)
      • conflict (2)
      • conflict (13)
      • modified residue (2)
      • modified residue (13)

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1a81A (A:)
    sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
    elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
    reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
    ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
    dgllrvltvpcqki
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1a81C (C:)
    sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
    elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
    reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
    ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
    dgllrvltvpcqki
    

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >1a81E (E:)
    sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
    elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
    reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
    ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
    dgllrvltvpcqki
    

    Sequence, based on observed residues (ATOM records): (download)
    >1a81E (E:)
    sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
    elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktpqlekliatta
    hekmpwfhgkisreeseqivligsktngkflirardnngsyalcllhegkvlhyridkdk
    tgklsipegkkfdtlwqlvehysykadgllrvltvpcqki
    

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >1a81G (G:)
    sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
    elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
    reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
    ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
    dgllrvltvpcqki
    

    Sequence, based on observed residues (ATOM records): (download)
    >1a81G (G:)
    sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
    elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktpqlekliatta
    hekmpwfhgkisreeseqivligsktngkflirardnngsyalcllhegkvlhyridkdk
    tgklsipegkkfdtlwqlvehysykadgllrvltvpcqki
    

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1a81I (I:)
    sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
    elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
    reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
    ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
    dgllrvltvpcqki
    

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    Sequence, based on SEQRES records: (download)
    >1a81K (K:)
    sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
    elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
    reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
    ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
    dgllrvltvpcqki
    

    Sequence, based on observed residues (ATOM records): (download)
    >1a81K (K:)
    sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
    elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktpqlekliatta
    hekmpwfhgkisreeseqivligsktngkflirardnngsyalcllhegkvlhyridkdk
    tgklsipegkkfdtlwqlvehysykadgllrvltvpcqki
    

  • Chain 'L':
    No sequence available.