PDB entry 1a81
View 1a81 on RCSB PDB site
Description: crystal structure of the tandem sh2 domain of the syk kinase bound to a dually tyrosine-phosphorylated itam
Class: complex (transferase/peptide)
Keywords: COMPLEX (TRANSFERASE-PEPTIDE), SYK, KINASE, SH2 DOMAIN, ITAM, COMPLEX (TRANSFERASE-PEPTIDE) complex
Deposited on
1998-03-31, released
1998-10-21
The last revision prior to the SCOPe 2.08 freeze date was dated
2016-05-25, with a file datestamp of
2016-05-20.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.11
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: syk kinase
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1a81a1, d1a81a2 - Chain 'B':
Compound: T-cell surface glycoprotein CD3 epsilon chain
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P07766 (0-17)
- conflict (2)
- conflict (13)
- modified residue (2)
- modified residue (13)
- Chain 'C':
Compound: syk kinase
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1a81c1, d1a81c2 - Chain 'D':
Compound: T-cell surface glycoprotein CD3 epsilon chain
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P07766 (0-17)
- conflict (2)
- conflict (13)
- modified residue (2)
- modified residue (13)
- Chain 'E':
Compound: syk kinase
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1a81e1, d1a81e2 - Chain 'F':
Compound: T-cell surface glycoprotein CD3 epsilon chain
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P07766 (0-17)
- conflict (2)
- conflict (13)
- modified residue (2)
- modified residue (13)
- Chain 'G':
Compound: syk kinase
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1a81g1, d1a81g2 - Chain 'H':
Compound: T-cell surface glycoprotein CD3 epsilon chain
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P07766 (0-17)
- conflict (2)
- conflict (13)
- modified residue (2)
- modified residue (13)
- Chain 'I':
Compound: syk kinase
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1a81i1, d1a81i2 - Chain 'J':
Compound: T-cell surface glycoprotein CD3 epsilon chain
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P07766 (0-17)
- conflict (2)
- conflict (13)
- modified residue (2)
- modified residue (13)
- Chain 'K':
Compound: syk kinase
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1a81k1, d1a81k2 - Chain 'L':
Compound: T-cell surface glycoprotein CD3 epsilon chain
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P07766 (0-17)
- conflict (2)
- conflict (13)
- modified residue (2)
- modified residue (13)
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1a81A (A:)
sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
dgllrvltvpcqki
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>1a81C (C:)
sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
dgllrvltvpcqki
- Chain 'D':
No sequence available.
- Chain 'E':
Sequence, based on SEQRES records: (download)
>1a81E (E:)
sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
dgllrvltvpcqki
Sequence, based on observed residues (ATOM records): (download)
>1a81E (E:)
sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktpqlekliatta
hekmpwfhgkisreeseqivligsktngkflirardnngsyalcllhegkvlhyridkdk
tgklsipegkkfdtlwqlvehysykadgllrvltvpcqki
- Chain 'F':
No sequence available.
- Chain 'G':
Sequence, based on SEQRES records: (download)
>1a81G (G:)
sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
dgllrvltvpcqki
Sequence, based on observed residues (ATOM records): (download)
>1a81G (G:)
sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktpqlekliatta
hekmpwfhgkisreeseqivligsktngkflirardnngsyalcllhegkvlhyridkdk
tgklsipegkkfdtlwqlvehysykadgllrvltvpcqki
- Chain 'H':
No sequence available.
- Chain 'I':
Sequence; same for both SEQRES and ATOM records: (download)
>1a81I (I:)
sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
dgllrvltvpcqki
- Chain 'J':
No sequence available.
- Chain 'K':
Sequence, based on SEQRES records: (download)
>1a81K (K:)
sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktgpfedlkenli
reyvkqtwnlqgqaleqaiisqkpqlekliattahekmpwfhgkisreeseqivligskt
ngkflirardnngsyalcllhegkvlhyridkdktgklsipegkkfdtlwqlvehysyka
dgllrvltvpcqki
Sequence, based on observed residues (ATOM records): (download)
>1a81K (K:)
sanhlpfffgnitreeaedylvqggmsdglyllrqsrnylggfalsvahgrkahhytier
elngtyaiaggrthaspadlchyhsqesdglvcllkkpfnrpqgvqpktpqlekliatta
hekmpwfhgkisreeseqivligsktngkflirardnngsyalcllhegkvlhyridkdk
tgklsipegkkfdtlwqlvehysykadgllrvltvpcqki
- Chain 'L':
No sequence available.