SCOPe 2.08: Structural Classification of Proteins

PDB entry 1a7a

View 1a7a on RCSB PDB site
Description: structure of human placental s-adenosylhomocysteine hydrolase: determination of a 30 selenium atom substructure from data at a single wavelength
Class: hydrolase
Keywords: hydrolase, nad binding protein
Deposited on 1998-03-10, released 1999-04-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.227
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: s-adenosylhomocysteine hydrolase
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P23526 (1-431)
  - engineered (28)
  - engineered (32)
  - engineered (34)
  - engineered (55)
  - engineered (126)
  - engineered (166-167)
  - engineered (209)
  - engineered (253)
  - engineered (261)
  - engineered (289)
  - engineered (350)
  - engineered (357)
  - engineered (366)
  - engineered (418)
Domains in SCOPe 2.08: d1a7aa1, d1a7aa2
Chain 'B':
Compound: s-adenosylhomocysteine hydrolase
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P23526 (Start-431)
  - engineered (28)
  - engineered (32)
  - engineered (34)
  - engineered (55)
  - engineered (126)
  - engineered (166-167)
  - engineered (209)
  - engineered (253)
  - engineered (261)
  - engineered (289)
  - engineered (350)
  - engineered (357)
  - engineered (366)
  - engineered (418)
Domains in SCOPe 2.08: d1a7ab1, d1a7ab2
Heterogens: NAD, ADC, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>1a7aA (A:)
msdklpykvadiglaawgrkaldiaenempglmrmrerysaskplkgariagclhmtvet
avlietlvtlgaevqwsscnifstqnhaaaaiakagipvyawkgetdeeylwcieqtlyf
kdgplnmilddggdltnlihtkypqllpgirgiseetttgvhnlykmmangilkvpainv
ndsvtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarvi
iteidpinalqaamegyevttmdeacqegnifvtttgcidiilgrhfeqmkddaivcnig
hfdveidvkwlnenavekvnikpqvdryrlkngrriillaegrlvnlgcamghpsfvmsn
sftnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgms
cdgpfkpdhyry

Sequence, based on observed residues (ATOM records): (download)

>1a7aA (A:)
sdklpykvadiglaawgrkaldiaenempglmrmrerysaskplkgariagclhmtveta
vlietlvtlgaevqwsscnifstqnhaaaaiakagipvyawkgetdeeylwcieqtlyfk
dgplnmilddggdltnlihtkypqllpgirgiseetttgvhnlykmmangilkvpainvn
dsvtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarvii
teidpinalqaamegyevttmdeacqegnifvtttgcidiilgrhfeqmkddaivcnigh
fdveidvkwlnenavekvnikpqvdryrlkngrriillaegrlvnlgcamghpsfvmsns
ftnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgmsc
dgpfkpdhyry

Chain 'B':
Sequence, based on SEQRES records: (download)

>1a7aB (B:)
msdklpykvadiglaawgrkaldiaenempglmrmrerysaskplkgariagclhmtvet
avlietlvtlgaevqwsscnifstqnhaaaaiakagipvyawkgetdeeylwcieqtlyf
kdgplnmilddggdltnlihtkypqllpgirgiseetttgvhnlykmmangilkvpainv
ndsvtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarvi
iteidpinalqaamegyevttmdeacqegnifvtttgcidiilgrhfeqmkddaivcnig
hfdveidvkwlnenavekvnikpqvdryrlkngrriillaegrlvnlgcamghpsfvmsn
sftnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgms
cdgpfkpdhyry

Sequence, based on observed residues (ATOM records): (download)

>1a7aB (B:)
dklpykvadiglaawgrkaldiaenempglmrmrerysaskplkgariagclhmtvetav
lietlvtlgaevqwsscnifstqnhaaaaiakagipvyawkgetdeeylwcieqtlyfkd
gplnmilddggdltnlihtkypqllpgirgiseetttgvhnlykmmangilkvpainvnd
svtkskfdnlygcreslidgikratdvmiagkvavvagygdvgkgcaqalrgfgarviit
eidpinalqaamegyevttmdeacqegnifvtttgcidiilgrhfeqmkddaivcnighf
dveidvkwlnenavekvnikpqvdryrlkngrriillaegrlvnlgcamghpsfvmsnsf
tnqvmaqielwthpdkypvgvhflpkkldeavaeahlgklnvkltkltekqaqylgmscd
gpfkpdhyry