PDB entry 1a4w

View 1a4w on RCSB PDB site
Description: crystal structures of thrombin with thiazole-containing inhibitors: probes of the s1' binding site
Class: hydrolase/hydrolase inhibitor
Keywords: SERINE PROTEASE-INHIBITOR, BLOOD COAGULATION, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 1998-02-06, released 1998-04-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.155
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: alpha-thrombin (large subunit)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1a4w.1
  • Chain 'I':
    Compound: hirugen
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: alpha-thrombin (small subunit)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1a4w.1
  • Heterogens: NA, QWE, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1a4wH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1a4wH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlkegqpsvlqvvnlpiverpvckdstriritdnmfca
gykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkk
wiqkvidq

  • Chain 'I':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1a4wL (L:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >1a4wL (L:)
dcglrplfekksledkterellesyi