PDB entry 1a4i

View 1a4i on RCSB PDB site
Description: human tetrahydrofolate dehydrogenase / cyclohydrolase
Class: oxidoreductase
Keywords: thf, bifunctional, dehydrogenase, cyclohydrolase, folate, oxidoreductase
Deposited on 1998-01-30, released 1999-02-09
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.199
AEROSPACI score: 0.62 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1a4ia1, d1a4ia2
  • Chain 'B':
    Compound: methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1a4ib1, d1a4ib2
  • Heterogens: NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1a4iA (A:)
mapaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaa
eeigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiap
ekdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgap
mhdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginy
vpddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrflekfkp
g

    Sequence, based on observed residues (ATOM records): (download) 
    >1a4iA (A:)
apaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaae
eigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiape
kdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapm
hdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginyk
vvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1a4iB (B:)
mapaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaa
eeigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiap
ekdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgap
mhdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginy
vpddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrflekfkp
g

    Sequence, based on observed residues (ATOM records): (download) 
    >1a4iB (B:)
apaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaae
eigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiape
kdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapm
hdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginyv
pddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle