PDB entry 1a46

View 1a46 on RCSB PDB site
Description: thrombin complexed with hirugen and a beta-strand mimetic inhibitor
Class: complex (serine protease/inhibitor)
Keywords: complex (serine protease/inhibitor)
Deposited on 1998-02-11, released 1998-05-27
The last revision prior to the SCOP 1.75 freeze date was dated 2003-04-01, with a file datestamp of 2007-07-06.
Experiment type: XRAY
Resolution: 2.12 Å
R-factor: 0.155
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: alpha-thrombin (large subunit)
    Species: HOMO SAPIENS
    Domains in SCOP 1.75: d1a46.1
  • Chain 'I':
    Compound: hirugen
    Species: Hirudo medicinalis
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09945 (Start-11)
      • modified residue (10)
  • Chain 'L':
    Compound: alpha-thrombin (small subunit)
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1a46.1
  • Heterogens: NA, BIC, OHO, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1a46H (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1a46H (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlkegqpsvlqvvnlpiverpvckdstriritdnmfca
gykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkk
wiqkvidqfg

  • Chain 'I':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1a46L (L:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >1a46L (L:)
dcglrplfekksledkterellesyi