PDB entry 1a3e

View 1a3e on RCSB PDB site
Description: complex of human alpha-thrombin with the bifunctional boronate inhibitor borolog2
Class: hydrolase/hydrolase inhibitor
Keywords: complex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex
Deposited on 1998-01-21, released 1998-06-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.17
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: alpha-thrombin (large subunit)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1a3e.1
  • Chain 'I':
    Compound: hirudin
    Species: Hirudo medicinalis [TaxId:6421]
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: alpha-thrombin (small subunit)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1a3e.1
  • Heterogens: T16, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >1a3eH (H:)
    ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
    vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
    pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
    itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
    thvfrlkkwiqkvidqfge
    

    Sequence, based on observed residues (ATOM records): (download)
    >1a3eH (H:)
    ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
    vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
    pdretaasllqagykgrvtgwgnlketkgqpsvlqvvnlpiverpvckdstriritdnmf
    cagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrl
    kkwiqkvidqf
    

  • Chain 'I':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >1a3eL (L:)
    tfgsgeadcglrplfekksledkterellesyidgr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1a3eL (L:)
    adcglrplfekksledkterellesyi