PDB entry 1a22

View 1a22 on RCSB PDB site
Description: human growth hormone bound to single receptor
Class: complex (hormone/receptor)
Keywords: complex (hormone/receptor), pituitary, hormone
Deposited on 1998-01-15, released 1998-04-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.187
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: growth hormone
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01241 (0-190)
      • engineered (119)
    Domains in SCOPe 2.07: d1a22a_
  • Chain 'B':
    Compound: growth hormone receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1a22b1, d1a22b2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1a22A (A:)
    fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
    psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleer
    iqtlmgrledgsprtgqifkqtyskfdtnshnddallknygllycfrkdmdkvetflriv
    qcrsvegscgf
    

    Sequence, based on observed residues (ATOM records): (download)
    >1a22A (A:)
    fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
    psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleer
    iqtlmgrlegqifkqtyskfdtdallknygllycfrkdmdkvetflrivqcrsvegscgf
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1a22B (B:)
    fsgseataailsrapwslqsvnpglktnsskepkftkcrsperetfschwtdevhhgtkn
    lgpiqlfytrrntqewtqewkecpdyvsagenscyfnssftsiwipycikltsnggtvde
    kcfsvdeivqpdppialnwtllnvsltgihadiqvrweaprnadiqkgwmvleyelqyke
    vnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgnygefsevlyvtlpqmsq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1a22B (B:)
    pkftkcrsperetfschwtlgpiqlfytrrntqewtqewkecpdyvsagenscyfnssft
    siwipycikltsnggtvdekcfsvdeivqpdppialnwtllngihadiqvrweaprnadi
    qkgwmvleyelqykevnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgnygef
    sevlyvtlpqms