SCOPe 2.08: Structural Classification of Proteins

PDB entry 3cu7

View 3cu7 on RCSB PDB site
Description: Human Complement Component 5
Class: immune system
Keywords: MG domain, complement, inflammation, anaphylatoxin, Cleavage on pair of basic residues, Complement alternate pathway, Complement pathway, Cytolysis, Glycoprotein, Immune response, Inflammatory response, Innate immunity, Membrane attack complex, Secreted, Immune System
Deposited on 2008-04-16, released 2008-06-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.11 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Complement C5
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P01031 (Start-1675)
  - see remark 999 (801)
Domains in SCOPe 2.08: d3cu7a1, d3cu7a2, d3cu7a3, d3cu7a4, d3cu7a5, d3cu7a6, d3cu7a7, d3cu7a8, d3cu7a9, d3cu7aa, d3cu7ab, d3cu7ac, d3cu7ad, d3cu7ae, d3cu7af
Chain 'B':
Compound: Complement C5
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P01031
  - see remark 999 (801)
Domains in SCOPe 2.08: d3cu7b1, d3cu7b2, d3cu7b3, d3cu7b4, d3cu7b5, d3cu7b6, d3cu7b7, d3cu7b8, d3cu7b9, d3cu7ba, d3cu7bb, d3cu7bc, d3cu7bd, d3cu7be
Heterogens: NAG, CD

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3cu7A (A:)
mgllgilcfliflgktwgqeqtyvisapkifrvgaseniviqvygyteafdatisiksyp
dkkfsyssghvhlssenkfqnsailtiqpkqlpggqnpvsyvylevvskhfskskrmpit
ydngflfihtdkpvytpdqsvkvrvyslnddlkpakretvltfidpegsevdmveeidhi
giisfpdfkipsnprygmwtikakykedfsttgtayfevkeyvlphfsvsiepeynfigy
knfknfeitikaryfynkvvteadvyitfgiredlkddqkemmqtamqntmlingiaqvt
fdsetavkelsyysledlnnkylyiavtviestggfseeaeipgikyvlspyklnlvatp
lflkpgipypikvqvkdsldqlvggvpvtlnaqtidvnqetsdldpsksvtrvddgvasf
vlnlpsgvtvlefnvktdapdlpeenqaregyraiaysslsqsylyidwtdnhkallvge
hlniivtpkspyidkithynylilskgkiihfgtrekfsdasyqsinipvtqnmvpssrl
lvyyivtgeqtaelvsdsvwlnieekcgnqlqvhlspdadayspgqtvslnmatgmdswv
alaavdsavygvqrgakkplervfqfleksdlgcgaggglnnanvfhlagltfltnanad
dsqendepckeilrprrtlqkkieeiaakykhsvvkkccydgacvnndetceqraarisl
gprcikafteccvvasqlranishkdmqlgrlhmktllpvskpeirsyfpeswlwevhlv
prrkqlqfalpdslttweiqgigisntgicvadtvkakvfkdvflemnipysvvrgeqiq
lkgtvynyrtsgmqfcvkmsavegictsespvidhqgtksskcvrqkvegssshlvtftv
lpleiglhninfsletwfgkeilvktlrvvpegvkresysgvtldprgiygtisrrkefp
yripldlvpkteikrilsvkgllvgeilsavlsqeginilthlpkgsaeaelmsvvpvfy
vfhyletgnhwnifhsdpliekqklkkklkegmlsimsyrnadysysvwkggsastwlta
falrvlgqvnkyveqnqnsicnsllwlvenyqldngsfkensqyqpiklqgtlpvearen
slyltaftvigirkafdicplvkidtalikadnfllentlpaqstftlaisayalslgdk
thpqfrsivsalkrealvkgnppiyrfwkdnlqhkdssvpntgtarmvettayalltsln
lkdinyvnpvikwlseeqrygggfystqdtinaieglteysllvkqlrlsmdidvsykhk
galhnykmtdknflgrpvevllnddlivstgfgsglatvhvttvvhktstseevcsfylk
idtqdieashyrgygnsdykrivacasykpsreesssgsshavmdislptgisaneedlk
alvegvdqlftdyqikdghvilqlnsipssdflcvrfrifelfevgflspatftvyeyhr
pdkqctmfystsnikiqkvcegaackcveadcgqmqeeldltisaetrkqtackpeiaya
ykvsitsitvenvfvkykatlldiyktgeavaekdseitfikkvtctnaelvkgrqylim
gkealqikynfsfryiypldsltwieywprdttcsscqaflanldefaediflngc

Sequence, based on observed residues (ATOM records): (download)

>3cu7A (A:)
eqtyvisapkifrvgaseniviqvygyteafdatisiksypdkkfsyssghvhlssenkf
qnsailtiqpkqlpggqnpvsyvylevvskhfskskrmpitydngflfihtdkpvytpdq
svkvrvyslnddlkpakretvltfidpegsevdmveeidhigiisfpdfkipsnprygmw
tikakykedfsttgtayfevkeyvlphfsvsiepeynfigyknfknfeitikaryfynkv
vteadvyitfgiredlkddqkemmqtamqntmlingiaqvtfdsetavkelsyysledln
nkylyiavtviestggfseeaeipgikyvlspyklnlvatplflkpgipypikvqvkdsl
dqlvggvpvtlnaqtidvnqetsdldpsksvtrvddgvasfvlnlpsgvtvlefnvktda
pdlpeenqaregyraiaysslsqsylyidwtdnhkallvgehlniivtpkspyidkithy
nylilskgkiihfgtrekfsdasyqsinipvtqnmvpssrllvyyivtgeqtaelvsdsv
wlnieekcgnqlqvhlspdadayspgqtvslnmatgmdswvalaavdsavygvqrgakkp
lervfqfleksdlgcgaggglnnanvfhlagltfltnanaddsqendepckeillqkkie
eiaakykhsvvkkccydgacvnndetceqraarislgprcikafteccvvasqlranisl
grlhmktllpvskpeirsyfpeswlwevhlvprrkqlqfalpdslttweiqgigisntgi
cvadtvkakvfkdvflemnipysvvrgeqiqlkgtvynyrtsgmqfcvkmsavegictse
spkcvrqkvegssshlvtftvlpleiglhninfsletwfgkeilvktlrvvpegvkresy
sgvtldprgiygtisrrkefpyripldlvpkteikrilsvkgllvgeilsavlsqegini
lthlpkgsaeaelmsvvpvfyvfhyletgnhwnifhsdpliekqklkkklkegmlsimsy
rnadysysvwkggsastwltafalrvlgqvnkyveqnqnsicnsllwlvenyqldngsfk
ensqyqpiklqgtlpvearenslyltaftvigirkafdicplvkidtalikadnfllent
lpaqstftlaisayalslgdkthpqfrsivsalkrealvkgnppiyrfwkdnlqhkdssv
pntgtarmvettayalltslnlkdinyvnpvikwlseeqrygggfystqdtinaieglte
ysllvkqlrlsmdidvsykhkgalhnykmtdknflgrpvevllnddlivstgfgsglatv
hvttvvhktstseevcsfylkidtqdiykrivacasykpsreesssgsshavmdislptg
isaneedlkalvegvdqlftdyqikdghvilqlnsipssdflcvrfrifelfevgflspa
tftvyeyhrpdkqctmfystsnikiqkvcegaackcveadcgqmqeeldltisaetrkqt
ackpeiayaykvsitsitvenvfvkykatlldiyktgeavaekdseitfikkvtctnael
vkgrqylimgkealqikynfsfryiypldsltwieywprdttcsscqaflanldefaedi
flngc

Chain 'B':
Sequence, based on SEQRES records: (download)

>3cu7B (B:)
mgllgilcfliflgktwgqeqtyvisapkifrvgaseniviqvygyteafdatisiksyp
dkkfsyssghvhlssenkfqnsailtiqpkqlpggqnpvsyvylevvskhfskskrmpit
ydngflfihtdkpvytpdqsvkvrvyslnddlkpakretvltfidpegsevdmveeidhi
giisfpdfkipsnprygmwtikakykedfsttgtayfevkeyvlphfsvsiepeynfigy
knfknfeitikaryfynkvvteadvyitfgiredlkddqkemmqtamqntmlingiaqvt
fdsetavkelsyysledlnnkylyiavtviestggfseeaeipgikyvlspyklnlvatp
lflkpgipypikvqvkdsldqlvggvpvtlnaqtidvnqetsdldpsksvtrvddgvasf
vlnlpsgvtvlefnvktdapdlpeenqaregyraiaysslsqsylyidwtdnhkallvge
hlniivtpkspyidkithynylilskgkiihfgtrekfsdasyqsinipvtqnmvpssrl
lvyyivtgeqtaelvsdsvwlnieekcgnqlqvhlspdadayspgqtvslnmatgmdswv
alaavdsavygvqrgakkplervfqfleksdlgcgaggglnnanvfhlagltfltnanad
dsqendepckeilrprrtlqkkieeiaakykhsvvkkccydgacvnndetceqraarisl
gprcikafteccvvasqlranishkdmqlgrlhmktllpvskpeirsyfpeswlwevhlv
prrkqlqfalpdslttweiqgigisntgicvadtvkakvfkdvflemnipysvvrgeqiq
lkgtvynyrtsgmqfcvkmsavegictsespvidhqgtksskcvrqkvegssshlvtftv
lpleiglhninfsletwfgkeilvktlrvvpegvkresysgvtldprgiygtisrrkefp
yripldlvpkteikrilsvkgllvgeilsavlsqeginilthlpkgsaeaelmsvvpvfy
vfhyletgnhwnifhsdpliekqklkkklkegmlsimsyrnadysysvwkggsastwlta
falrvlgqvnkyveqnqnsicnsllwlvenyqldngsfkensqyqpiklqgtlpvearen
slyltaftvigirkafdicplvkidtalikadnfllentlpaqstftlaisayalslgdk
thpqfrsivsalkrealvkgnppiyrfwkdnlqhkdssvpntgtarmvettayalltsln
lkdinyvnpvikwlseeqrygggfystqdtinaieglteysllvkqlrlsmdidvsykhk
galhnykmtdknflgrpvevllnddlivstgfgsglatvhvttvvhktstseevcsfylk
idtqdieashyrgygnsdykrivacasykpsreesssgsshavmdislptgisaneedlk
alvegvdqlftdyqikdghvilqlnsipssdflcvrfrifelfevgflspatftvyeyhr
pdkqctmfystsnikiqkvcegaackcveadcgqmqeeldltisaetrkqtackpeiaya
ykvsitsitvenvfvkykatlldiyktgeavaekdseitfikkvtctnaelvkgrqylim
gkealqikynfsfryiypldsltwieywprdttcsscqaflanldefaediflngc

Sequence, based on observed residues (ATOM records): (download)

>3cu7B (B:)
eqtyvisapkifrvgaseniviqvygyteafdatisiksypdkkfsyssghvhlssenkf
qnsailtiqpkqlpggqnpvsyvylevvskhfskskrmpitydngflfihtdkpvytpdq
svkvrvyslnddlkpakretvltfidpegsevdmveeidhigiisfpdfkipsnprygmw
tikakykedfsttgtayfevkeyvlphfsvsiepeynfigyknfknfeitikaryfynkv
vteadvyitfgiredlkddqkemmqtamqntmlingiaqvtfdsetavkelsyysledln
nkylyiavtviestggfseeaeipgikyvlspyklnlvatplflkpgipypikvqvkdsl
dqlvggvpvtlnaqtidvnqetsdldpsksvtrvddgvasfvlnlpsgvtvlefnvktda
pdlpeenqaregyraiaysslsqsylyidwtdnhkallvgehlniivtpkspyidkithy
nylilskgkiihfgtrekfsdasyqsinipvtqnmvpssrllvyyivtgeqtaelvsdsv
wlnieekcgnqlqvhlspdadayspgqtvslnmatgmdswvalaavdsavygvqrgakkp
lervfqfleksdlgcgaggglnnanvfhlagltfltnanaddsqendepckeillqkkie
eiaakykhsvvkkccydgacvnndetceqraarislgprcikafteccvvasqlranisl
grlhmktllpvskpeirsyfpeswlwevhlvprrkqlqfalpdslttweiqgigisntgi
cvadtvkakvfkdvflemnipysvvrgeqiqlkgtvynyrtsgmqfcvkmsavegictse
spkcvrqkvegssshlvtftvlpleiglhninfsletwfgkeilvktlrvvpegvkresy
sgvtldprgiygtisrrkefpyripldlvpkteikrilsvkgllvgeilsavlsqegini
lthlpkgsaeaelmsvvpvfyvfhyletgnhwnifhsdpliekqklkkklkegmlsimsy
rnadysysvwkggsastwltafalrvlgqvnkyveqnqnsicnsllwlvenyqldngsfk
ensqyqpiklqgtlpvearenslyltaftvigirkafdicplvkidtalikadnfllent
lpaqstftlaisayalslgdkthpqfrsivsalkrealvkgnppiyrfwkdnlqhkdssv
pntgtarmvettayalltslnlkdinyvnpvikwlseeqrygggfystqdtinaieglte
ysllvkqlrlsmdidvsykhkgalhnykmtdknflgrpvevllnddlivstgfgsglatv
hvttvvhktstseevcsfylkidtqdiykrivacasykpsreesssgsshavmdislptg
isaneedlkalvegvdqlftdyqikdghvilqlnsipssdflcvrfrifelfevgflspa
tftvyeyhrpdkqctmfystsnikiqkvcegaackcveadc