Structural Classification of Proteins
Root: scop
Classes:
- All alpha proteins [46456] (284)
- Globin-like [46457] (2)
core: 6 helices; folded leaf, partly opened
- Long alpha-hairpin [46556] (20)
2 helices; antiparallel hairpin, left-handed twist
- Type I dockerin domain [63445] (1)
tandem repeat of two calcium-binding loop-helix motifs, distinct from the EF-hand
- LEM/SAP HeH motif [63450] (6)
helix-extended loop-helix; parallel helices
- SOCS box-like [158234] (1)
helix-loop-helix motif with orthogonally packed helices
- RPB6/omega subunit-like [63561] (1)
core: 2 helices and adjacent loops
- KRAB domain (Kruppel-associated box) [109639] (1)
2 helices: one short, one long; aromatic-rich iterface
- Cytochrome c [46625] (1)
core: 3 helices; folded leaf, opened
- DNA/RNA-binding 3-helical bundle [46688] (14)
core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
- Another 3-helical bundle [81602] (5)
topologically similar to the DNA/RNA-binding bundles; distinct packing
- RuvA C-terminal domain-like [46928] (9)
3 helices; bundle, right-handed twist
- S13-like H2TH domain [81297] (1)
core: 3-4 helices
- Putative DNA-binding domain [46954] (1)
core: 3 helices; architecture is similar to that of the "winged helix" fold but topology is different
- Spectrin repeat-like [46965] (16)
3 helices; bundle, closed, left-handed twist; up-and-down
- immunoglobulin/albumin-binding domain-like [46996] (11)
3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold
- Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47004] (1)
3 helices; bundle, closed, right-handed twist; up-and-down
- ChaB-like [140375] (1)
3 helices, the first one is shorter than the other two; bundle, capped by a small, C-terminal beta-hairpin
- Protozoan pheromone-like [47013] (2)
3 helices; bundle, closed, left-handed twist, up-and-down
- Acyl-CoA binding protein-like [47026] (2)
core: 3 helices; bundle, closed, left-handed twist; up-and-down
- YqgQ-like [158378] (1)
3 helices, bundle, left-handed twist, extended overside connection between the first and second helices
- Kix domain of CBP (creb binding protein) [47039] (1)
3 helices; bundle, partly opened
- RAP domain-like [47044] (1)
3 helices, the first one is shorter than the other two; bundle, partly opened
- VHP, Villin headpiece domain [47049] (1)
3 short helices; irregular array
- BSD domain-like [140382] (1)
core: 3 helices; triangular array; the extra N-terminal and C-terminal helices form a coiled coil structure
- TAF(II)230 TBP-binding fragment [47054] (1)
3 short helices; irregular array
- S15/NS1 RNA-binding domain [47059] (1)
3 helices; irregular array
- Frizzled cysteine-rich domain [63500] (1)
Core: 3 helices; irregular array; disulfide-rich
- T4 endonuclease V [47076] (1)
3 helices; irregular array
- Fertilization protein [47081] (1)
core: 3 helices; bundle, closed, right-handed twist; up-and-down
- PGBD-like [47089] (1)
core: 3 helices; bundle, closed, left-handed twist; parallel
- HMG-box [47094] (1)
3 helices; irregular array
- Histone-fold [47112] (1)
core: 3 helices; long middle helix is flanked at each end with shorter ones
- Open three-helical up-and-down bundle [47143] (7)
core: 3 helices; bundle, open
- beta-catenin-interacting protein ICAT [81729] (1)
core: 3 helices; irregular array
- DNA polymerase III theta subunit-like [116730] (1)
3 helices; irregular array
- Four-helical up-and-down bundle [47161] (28)
core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down
- PTS-regulatory domain, PRD [63519] (1)
core: 4 helices; bundle, closed, right-handed twist; 1 crossover connection
- Ferritin-like [47239] (6)
core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection
- 4-helical cytokines [47265] (1)
core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
- Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1)
core: 4 helices; bundle; one loop crosses over one side of the bundle
- Acyl carrier protein-like [47335] (3)
4 helices, bundle; helix 3 is shorter than others; up-and-down
- Bromodomain-like [47363] (15)
4 helices; bundle; minor mirror variant of up-and-down topology
- ROP-like [47379] (8)
4 helices; dimer of identical alpha-hairpin subunits; bundle, closed, left-handed twist
- Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [47390] (1)
4 helices; bundle, closed, right-handed twist
- Orange domain-like [158456] (1)
4 helices; dimer of identical alpha-hairpin subunits;
- Soluble domain of poliovirus core protein 3a [89042] (1)
4 helices; bundle, closed, right-handed twist
- Transcription factor IIA (TFIIA), alpha-helical domain [47395] (1)
4 helices; bundle, closed, right-handed twist
- Ectatomin subunits [47400] (1)
4 helices; bundle, closed, left-handed twist
- Dimerisation interlock [47405] (4)
4 helices; bundle, closed, right-handed twist
- lambda repressor-like DNA-binding domains [47412] (1)
core: 4 helices; folded leaf, closed
- Signal peptide-binding domain [47445] (1)
4 helices; orthogonal array
- A DNA-binding domain in eukaryotic transcription factors [47453] (1)
4 helices; the long C-terminal helix protrudes from the domain and binds to DNA
- HLH-like [47458] (2)
4-helices; bundle, closed, left-handed twist; 2 crossover connections
- HAMP domain-like [158471] (1)
dimer of helix-loop-helix segments; distict from the HLH-like fold; parallel four-helical bundle with two overside connections
- EF Hand-like [47472] (4)
core: 4 helices; array of 2 hairpins, opened
- CH domain-like [47575] (3)
core: 4 helices: bundle
- Domain of poly(ADP-ribose) polymerase [47586] (1)
core: 4 helices: bundle; unusual topology
- SWIB/MDM2 domain [47591] (1)
core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
duplication: consists of two structural repeats
- Pre-protein crosslinking domain of SecA [81766] (1)
core: 4 helices: bundle; flanked by two short beta-hairpins
duplication: consists of two structural repeats
- Ribbon-helix-helix [47597] (1)
core: 4 helices; array of 2 hairpins, opened
- GST C-terminal domain-like [47615] (1)
core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
- Methionine synthase domain-like [47643] (3)
4 helices; bundle, left-handed twist; right-handed superhelix
- KaiA/RbsU domain [101214] (1)
4 helices; bundle, right-handed twist; right-handed superhelix
- STAT-like [47654] (6)
4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix
- N-cbl like [47667] (5)
4 helices; bundle, left-handed twist; left-handed superhelix
- Replisome organizer (g39p helicase loader/inhibitor protein) [89063] (1)
4 helices; bundle, right-handed twist; left-handed superhelix
- Hypothetical protein YqbG [116914] (1)
core: 4 helices; bundle, right-handed twist; left-handed superhelix
- DnaD domain-like [158498] (1)
4 helices; bundle, right-handed twist; left-handed superhelix
- C-terminal domain of B transposition protein [47680] (1)
4 helices; irregular array
- HAND domain of the nucleosome remodeling ATPase ISWI [101223] (1)
4 helices; irregular array
- N-terminal, cytoplasmic domain of anti-sigmaE factor RseA [89068] (1)
4 helices; irregular array
- Anaphylotoxins (complement system) [47685] (1)
4 helices; irregular array, disulfide-linked
- Cytochrome c oxidase subunit h [47693] (1)
4 helices; irregular array, disulfide-linked
- Crustacean CHH/MIH/GIH neurohormone [81777] (1)
4 helices; irregular array, disulfide-linked
- C-terminal domain of DFF45/ICAD (DFF-C domain) [81782] (1)
4 helices; folded leaf; right-handed superhelix
- BH2638-like [158503] (1)
4 helices, folded leaf, right-handed superhelix; some similarity to the DFF-C domain fold (scop_cf 81782)
- Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47698] (1)
4 helices; folded leaf; right-handed superhelix
- p53 tetramerization domain [47718] (1)
core: 4 helices; bundle
- Bcr-Abl oncoprotein oligomerization domain [69035] (1)
core: 4 long helices; bundle
- Domain of early E2A DNA-binding protein, ADDBP [47723] (1)
4 helices; bundle, partly opened
- IHF-like DNA-binding proteins [47728] (1)
core: 4 helices; bundle, partly opened, capped with a beta-sheet
- TraM-like [140580] (1)
multihelical oligomeric protein; structure of whole subunit is not known; the N-terminal part is implicated in DNA binding, the middle region forms tetrameric parallel coiled coil, surrounded by the C-terminal helices
- CO dehydrogenase ISP C-domain like [47740] (1)
core: 4 helices, bundle
- Protein HNS-dependent expression A; HdeA [47751] (1)
4 helices; the three last helices form a bundle similar to that of the RuvA C-domain
- PABP domain-like [63569] (2)
4 helices; an orthogonal array
- Chemotaxis receptor methyltransferase CheR, N-terminal domain [47756] (1)
4 helices; an orthogonal array
- Dcp2 domain-like [140585] (1)
4 helices; orthogonal array of two alpha hairpins
- Type III secretion system domain [140590] (1)
core: 4 helices, orthogonal array; right-handed superhelix
- YugE-like [116921] (1)
4-helices; bundle; right-handed twist
- PWI domain [101232] (1)
4 helices; up-and-down bundle; topological similarity to the bromodomain-like and SAM domain-like folds
- PAH2 domain [47761] (1)
4 helices; open up-and-down bundle; binds alpha-helical peptides
- Myosin phosphatase inhibitor 17kDa protein, CPI-17 [81789] (1)
4 helices; open up-and-down bundle; flexible N-terminal tail
- XPC-binding domain [101237] (1)
4 helices; array
- DinB/YfiT-like putative metalloenzymes [109853] (1)
core: 4 helices; bundle, closed, left-handed twist; an unusual topology with a higher contact order
- EspA/CesA-like [116926] (1)
4 helices; bundle, closed, left ight-handed twist; interlocked (hetero)dimer of 2-helical subunits
- NblA-like [109858] (1)
4 helices; dimer of identical alpha-hairpin subunits; open bundle
- EF2947-like [140606] (1)
4 helices; "diamond" array; duplication: N-terminal and C-terminal pairs of helices are related by pseudo dyad
- EB1 dimerisation domain-like [140611] (1)
dimeric 4-helical bundle with a coiled coil at one end formed by the longer N-terminal helices
- SAM domain-like [47768] (16)
4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
- Retroviral matrix proteins [47835] (1)
4-5 helices; right-handed superhelix
- Flavivirus capsid protein C [101256] (1)
core: 5 helices; right-handed superhelix; swapped dimer with the two long C-terminal helices
- Hepatitis B viral capsid (hbcag) [47851] (1)
5 helices; array; two long helices form a hairpin that dimerizes into a 4-helical bundle
- Apolipophorin-III [47856] (1)
5 helices; bundle, closed, left-handed twist
- Methenyltetrahydrofolate cyclohydrolase-like [101261] (1)
5 helices; bundle, closed, left-handed twist
- A middle domain of Talin 1 [109879] (1)
5 helices; bundle, closed, left-handed twist; helices 2-5 adopt the Four-helical up-and-down bundle fold (scop_cf 47161)
- I/LWEQ domain [109884] (1)
5 helices; bundle, closed, left-handed twist
- RNA-binding protein She2p [116941] (1)
5 helices; bundle, closed, left-handed twist; topological similarity to the middle domain of the L-aspartase-like fold (scop_cf 48556)
- Hyaluronidase domain-like [140656] (3)
5 helices; bundle, closed, left-handed twist; up-and-down (meander) topology
- YoaC-like [140669] (1)
5 helices; bundle, one crossover connection, the arrangement of the first four helices is similar to the KaiA/RbsU domain fold (scop_cf 101214)
- Saposin-like [47861] (2)
5 helices; folded leaf, closed
- Annexin [47873] (1)
5 helices; folded leaf, closed
- TAFH domain-like [158552] (1)
5 helices; folded leaf, closed
- Transducin (alpha subunit), insertion domain [47894] (1)
5 helices; folded leaf
- Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47911] (1)
5 helices; irregular array; left-handed superhelix
- Left-handed superhelix [47916] (4)
core: 4-5 helices; bundle; left-handed superhelix
- ATPD N-terminal domain-like [47927] (2)
core: 5 helices; bundle
- ERP29 C domain-like [47932] (2)
5 helices; bundle
- Functional domain of the splicing factor Prp18 [47937] (1)
core: 5 helices; bundle
- Retrovirus capsid protein, N-terminal core domain [47942] (1)
core: 5 helices; bundle
- GINS helical bundle-like [158572] (1)
5 helices, staggered bundle;
- Jann4075-like [158586] (1)
core: 5 helices; the C-terminal helix is surrounded by the others; similarity to some EF-hand domains
- Cyclin-like [47953] (1)
core: 5 helices; one helix is surrounded by the others
- Arp2/3 complex 21 kDa subunit ARPC3 [69059] (1)
5 helices; one helix is surrounded by the others
- RNase III domain-like [69064] (1)
core: 5 helices; one helix is surrounded by the others
- Ribosomal protein S7 [47972] (1)
core: 5 helices; contains one more helix and a beta-hairpin outside the core
- post-AAA+ oligomerization domain-like [48018] (1)
core: 5 helices: bundle
- PAP/OAS1 substrate-binding domain [81632] (1)
core: 5-helical bundle; up-and-down; right-handed twist
- Anti-sigma factor AsiA [69069] (1)
core: 5 helices: orthogonal array
- Antibiotic binding domain of TipA-like multidrug resistance regulators [89081] (1)
5 helices: orthogonal array
- Surp module (SWAP domain) [109904] (1)
5 helices: irregular array
- YgfY-like [109909] (1)
5 helices; array; forms a tight dimer in crystals
- Hypothetical protein YhaI [109914] (1)
core: 5 helices; orthogonal array; folding similarity to the TipA-S domain (1ny9)
- Hypothetical protein At3g22680 [109919] (1)
5 helices; array; probable biological unit is a homodimer
- SP0561-like [140682] (1)
5 helices; array; includes extra N-terminal and C-terminal short strands forming parrallel beta-sheet ladder
- RbcX-like [158614] (1)
5 helices per subunit; irregular array of short and long helices; swapping of the C-terminal helices in the dimer
- YheA-like [158621] (1)
5 helices; "kinked" antiparallel coiled coil; forms flexible oligomeric assemblies via two different dimerisation interfaces
- RPA2825-like [158633] (1)
5 helices, array; long flexible loop between helices 1 and 2; the remaining helices are arranged similar to the PGBD-like fold (scop_cf 47089)
- ENT-like [158638] (1)
5 helices, irregular array, right-handed superhelix
- YfmB-like [140687] (1)
5 helices, array; buried N-terminal helix; some topological similarity (circular permutation?) to the Nucleotidyltransferase substrate binding subunit/domain (scop_sf 81593)
- N-terminal domain of adenylylcyclase associated protein, CAP [101277] (1)
6 helices: bundle; left-handed twist, up-and-down topology
- IpaD-like [140692] (1)
6 helices; bundle, up-and-down; can be divided into two four-helical bundles sharing two helices (3 and 6), which are twice longer than the rest
- Iron-dependent repressor protein, dimerization domain [47978] (1)
6 helices, homodimer of 3-helical domains
- Glutamyl tRNA-reductase dimerization domain [69074] (1)
6 helices, homodimer of 3-helical domains
- GRIP domain [101282] (1)
6 helices, homodimer of 3-helical domains
- BAR/IMD domain-like [116747] (1)
6 helices, homodimer of 3-helical domains
- L27 domain [101287] (1)
6 helices, heterodimer of 3-helical domains
- Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [109924] (1)
dimer of 3-helical segments; consists of two subdomains: 4-helical bundle and coiled coil
- Phage replication organizer domain [140712] (1)
6 helices, homodimer of 3-helical domains
- YejL-like [158650] (1)
6 helices; intertwined homodimer of three-helical subunits, bundle
- Mediator hinge subcomplex-like [140717] (1)
6 helices; heterodimer of structurally similar subunits; the N-terminal hairpins form a four-helical bundle, whereas the C-terminal helices form coiled coil structure
- DEATH domain [47985] (1)
6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
- GntR ligand-binding domain-like [48007] (1)
core: 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
- AF0941-like [140725] (1)
6 helices, arranged into two interconnected 3-helical bundles; can also be described as a 'kinked' four-helical bundle; right-handed superhelix
- NusB-like [48012] (1)
6 helices: bundle; one central helix is surrounded by 5 others
- YutG-like [101306] (1)
core: 6 helices; bundle; one central helix is surrounded by 5 others
- N-terminal domain of DnaB helicase [48023] (1)
6 helices: array
- Invasion protein A (SipA) , C-terminal actin binding domain [101311] (1)
6 helices: orthogonal array
- MtlR-like [158667] (1)
multihelical; 8-helical up-and-down bundle
- Guanido kinase N-terminal domain [48033] (1)
irregular array of 6 short helices
- Scaffolding protein gpD of bacteriophage procapsid [48044] (1)
core: 6 helices; one central helix is surrounded by 5 others
- Hemocyanin, N-terminal domain [48049] (1)
6 helices; bundle; one central helix is surrounded by 5 others
- Sama2622-like [158674] (1)
core: 6 helices; bundle; one central helix is surrounded by 5 others
- Di-copper centre-containing domain [48055] (1)
multihelical
- DBL homology domain (DH-domain) [48064] (1)
multihelical; core: 5-helical bundle
- LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48075] (1)
multihelical; contains compact array of 6 short helices
- RuBisCo LSMT C-terminal, substrate-binding domain [81821] (1)
multihelical; irregular array of long and short helices
- Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48080] (1)
multihelical bundle; contains buried central helix
- YcfC-like [101321] (1)
multihelical; contains two buried central helices
- PA2201 C-terminal domain-like [140730] (1)
multihelical; seven-helical bundle with buried central helix
- Rv1873-like [140735] (1)
multihelical; contains unusually short buried central helix
- RUN domain-like [140740] (1)
multihelical; 3-helical bundle similar to one half of the DEATH domain fold is flanked by two alpha-hairpins forming a four-helical bundle; the axes of the three-helical and four-helical bundles are aproximately orthogonal to each other
- SipA N-terminal domain-like [140745] (1)
multihelical; bundle; the last helix is buried inside the bundle
- Transcription factor STAT-4 N-domain [48091] (1)
multihelical; can be divided into two subdomains
- TerB-like [158681] (1)
multihelical; contains two central helices; duplication: there are two three-helical repeats related by pseudo twofold symmetry
- Regulator of G-protein signaling, RGS [48096] (1)
multihelical; consists of two all-alpha subdomains
contains a 4-helical bundle with left-handed twist and up-and-down topology
- SopE-like GEF domain [81831] (1)
multihelical; consists of two all-alpha subdomains each containing a 3-helical bundle with right-handed twist
- Variable surface antigen VlsE [74747] (1)
multihelical; consists of two all-alpha subdomains; contains a 4-helical bundle with left-handed twist and up-and-down topology
- YgfB-like [101326] (1)
multihelical; consists of two tightly associated 3-helical bundles with different twists
- Hypothetical protein MTH393 [101331] (1)
multihelical; consists of two all-alpha subdomains; dimer
- PG0816-like [140752] (1)
multihelical; comprises two helical bundles, both are topologically similar to the RuvA C-terminal domain-like fold (scop_cf 46928)
- UraD-like [158693] (1)
multihelical; irregular array of long and short helices
- Sec63 N-terminal domain-like [158701] (1)
multihelical; consists of two helical subdomains
- Carbamoyl phosphate synthetase, large subunit connection domain [48107] (1)
multihelical; consists of two all-alpha subdomains
possible duplication: subdomains have similar topologies
- Heme-dependent peroxidases [48112] (1)
multihelical; consists of two all-alpha domains
- Ribosomal protein L19 (L19e) [48139] (1)
multihelical; consists of two different 3-helical domains connected by a long, partly helical linker
- PSPTO4464-like [158709] (1)
multihelical; consists of two subdomains at the ends of a long connecting helix
- GatB/YqeY motif [89094] (1)
multihelical; consists of two different alpha-helical bundles (4-helical and 3-helical)
- YfbU-like [116959] (1)
multihelical; consist of two subdomains; forms 24-mer with the N-terminal sudbomains packing around the 4-fold axis and the C-terminal domains interacting at the 2-fold and 3-fold axes
- MG296-like [158714] (1)
multihelical; in crystal forms helical polymers by swapping the two N-terminal helices to the next subunit in polymer; three subunits per turn of polymer helix
- Hypothetical protein MPN330 [116964] (1)
multihelical; consists of three different 4-helical bundles
- HD-domain/PDEase-like [109603] (1)
multihelical; consists of two different alpha-helical bundles
- Superantigen MAM [101343] (1)
multihelical; consists of two different alpha-helical bundles
- Influenza virus matrix protein M1 [48144] (1)
multihelical; consists of two different all-alpha subdomains, 4 helices each
- DNA-glycosylase [48149] (1)
multihelical; consists of two all-alpha domains
- An anticodon-binding domain of class I aminoacyl-tRNA synthetases [48162] (1)
multihelical; consists of two all-alpha domains
- Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) [101352] (1)
multihelical; consists of two all-alpha subdomains
- R1 subunit of ribonucleotide reductase, N-terminal domain [48167] (1)
multihelical consists of two all-alpha subdomains
subdomain 1 (residues 10-100) is a 4-helical bundle
- BEACH domain [81836] (1)
multihelical, complex architecture
- Cryptochrome/photolyase FAD-binding domain [48172] (1)
multihelical; consists of two all-alpha subdomains
- 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1)
multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
- Uteroglobin-like [48200] (1)
multihelical
- alpha/alpha toroid [48207] (6)
multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies
- Citrate synthase [48255] (1)
multihelical; consists of two all-alpha domains
- Cytochrome P450 [48263] (1)
multihelical
- Flagellar transcriptional activator FlhD [63591] (1)
multihelical; forms intertwined dimer of identical 5-helical subunits
- HP0242-like [158751] (1)
multihelical; intertwined homodimer of four-helical subunits, forming catenated triangular ring-like structures; pseudo knot
- SMc04008-like [158756] (1)
multihelcal; intertwined homodimer; there are 4 core helices in each subunits; contains putative metal ion-binding motif MxxxxxCxxC in the conserved surface site
- Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48299] (1)
multihelical; intertwined tetramer
- Class II MHC-associated invariant chain ectoplasmic trimerization domain [48304] (1)
multihelical; intertwined trimer of identical 3-helical subunits
- Aldehyde ferredoxin oxidoreductase, C-terminal domains [48309] (1)
multihelical; consists of two all-alpha domains
- Acid phosphatase/Vanadium-dependent haloperoxidase [48316] (1)
multihelical; core: 5-helical bundle; binds cofactor at the beginning of third helix
- BRCA2 helical domain [81871] (1)
multihelical; contains a 3-helical bundle surrounded by several shorter helices
- BRCA2 tower domain [81877] (1)
multihelical; contains a 3-helical Hin recombinase-like subdomain and two long dimerisation helices
- H-NS histone-like proteins [81274] (1)
multihelical oligomeric protein; structure of whole subunit is not known yet but are probably composed of three different domains
- Sigma2 domain of RNA polymerase sigma factors [88945] (1)
multihelical; consists of a conserved 4-helical core and a variable insert subdomain
- DNA repair protein MutS, domain III [48333] (1)
multihelical; consists of 2 all-alpha subdomains
- Helical scaffold and wing domains of SecA [81885] (1)
multihelical; consists of 2 all-alpha subdomains
- all-alpha NTP pyrophosphatases [101385] (1)
multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer
- Hsp90 co-chaperone CDC37 [101390] (1)
multihelical; consists of 2 all-alpha subdomains connected by a long helix
- Nop domain [89123] (1)
multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain
- YidB-like [140803] (1)
multihelical; three strings of short helices are packed across one longer helix
- Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48339] (1)
multihelical; bundle of longer and shorter helices
- A virus capsid protein alpha-helical domain [48344] (1)
multihelical; three-helical bundle in the core is surrounded by non-conserved helices
- P40 nucleoprotein [101398] (1)
multihelical; consists of two subdomains
- Rhabdovirus nucleoprotein-like [140808] (1)
multihelical, consist of two helical domains; each domain contains a buried helix
- GTPase activation domain, GAP [48349] (1)
multihelical
- Ras GEF [48365] (1)
multihelical
- Telomeric repeat binding factor (TRF) dimerisation domain [63599] (1)
multihelical; can be divided into an alpha-alpha superhelix domain and a long alpha-hairpin dimerization domain
- Poly A polymerase C-terminal region-like [81890] (1)
multihelical; can be divided into three subdomains (neck, body and tail)
- alpha-alpha superhelix [48370] (24)
multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix
- GUN4-like [140868] (1)
multihelical; open array, trapping inside an extended region before the C-terminal helix
- Lipoxigenase [48483] (1)
multihelical
large nearly all-alpha domain
- gene 59 helicase assembly protein [48492] (1)
multihelical; consists of two all-alpha subdomains
- Tetracyclin repressor-like, C-terminal domain [48497] (1)
multihelical; interlocked (homo)dimer
- Skp1 dimerisation domain-like [81384] (1)
multihelical; interlocked heterodimer with F-box proteins
- F-box domain [81385] (1)
multihelical; interlocked heterodimer with the Skp1 dimerisation domain
- Nuclear receptor ligand-binding domain [48507] (1)
multihelical; 3 layers or orthogonally packed helices
- Phospholipase C/P1 nuclease [48536] (1)
multihelical
- ATP-dependent DNA ligase DNA-binding domain [117017] (1)
multihelical; duplication: contains two intertwined structural repeats related by pseudo twofold symmetry
- DNA primase DnaG, C-terminal domain [117022] (1)
multihelical; segment-swapped dimer
- PriB N-terminal domain-like [140913] (1)
multihelical bundle; contains buried central helix; also includes the PriA interface-forming insert subdomain (alpha+beta)
- VPS9 domain [109992] (1)
multihelical; consist of two subdomains
- Triger factor/SurA peptide-binding domain-like [109997] (1)
multihelical; irregular array of long and short helices
- DNA terminal protein [140918] (1)
multihelical, open array; contains the C-terminal four-helical bundle, left-handed superhelix
- Glycolipid transfer protein, GLTP [110003] (1)
multihelical; 2 layers or orthogonally packed helices
- Hypothetical protein MG354 [110008] (1)
multihelical bundle; contains buried central helix
- Duffy binding domain-like [140923] (1)
consist of two subdomains, each containing a three-helical bundle
- Fic-like [140930] (1)
multihelical; one central helix is surrounded by seven helices
- Her-1 [110013] (1)
multihelical; consists of two topologically similar alpha-helical bundles
- ERO1-like [110018] (1)
multihelical; consists of 2 four-helical bundles
- Serum albumin-like [48551] (1)
multihelical; one domain consists of two similar disulfide-linked subdomains
- L-aspartase-like [48556] (1)
multihelical, consists of three all-alpha domains
- Formin homology 2 domain (FH2 domain) [101446] (1)
multihelical, consists of three all-alpha domains
- Terpenoid synthases [48575] (1)
multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers
- GroEL equatorial domain-like [48591] (1)
multihelical; 8 helices arranged in 2 parallel layers
- TorD-like [89154] (1)
multihelical; bundle
- Chorismate mutase II [48599] (1)
multihelical; core: 6 helices, bundle
- Peridinin-chlorophyll protein [48607] (1)
multihelical: forms a boat-shaped protein shell around cofactors
- Heme oxygenase-like [48612] (1)
multihelical; bundle
- Indolic compounds 2,3-dioxygenase-like [140958] (1)
multihelical; bundle, contains interrupted helices
- AhpD-like [69117] (1)
multihelical; contains 4-helical bundle and 2-helical arm
- Double Clp-N motif [81922] (1)
multihelical; array
- Orange carotenoid protein, N-terminal domain [81929] (1)
multihelical; array
- DhaL-like [101472] (1)
multihelical; bundle
- ADP-ribosylglycohydrolase [101477] (1)
multihelical; bundle
- Topoisomerase V catalytic domain-like [140978] (1)
multihelical; irregular array; contains small amount of beta-structure and a 3-helical bundle with a variant homeofomain-like fold and HTH motif (scop_cf 46688)
- PTPA-like [140983] (1)
multihelical
- Tex N-terminal region-like [158831] (1)
multihelical; irregular array of long and short helices; can be divided into several subdomains
- AGR_C_984p-like [158836] (1)
multihelical, consists of two subdomains; duplication: there are two 5-helical structural repeats, one in each subdomain
- PMT central region-like [158841] (1)
multihelical; comprises two four-helical bundles of different topologies and an irregular helical array packed against a small beta-sheet
- FtsH protease domain-like [140989] (1)
array of 6 helices and a 2-stranded beta-ribbon
- Gametocyte protein Pfg27 [89161] (1)
multihelical; bundle
- N-terminal domain of bifunctional PutA protein [81934] (1)
multihelical; array
- Cysteine alpha-hairpin motif [47071] (1)
core: alpha-hairpin crosslinked with two disulfides
- Phospholipase A2, PLA2 [48618] (1)
common core: 2 helices, disulfide-linked, and a calcium-binding loop
- Fungal elicitin [48646] (1)
5 helices: irregular disulfide-linked array; also contains a small beta-hairpin
- Tetraspanin [48651] (1)
5 helices: irregular disulfide-linked array; form homodimer
- GDNF receptor-like [110034] (1)
5 helices: irregular disulfide-linked array; topological similarity to the Fungal elicitin fold (scop_cf 48646)
- FinO-like [48656] (1)
6 helices: irregular non-globular array; also contains two small beta-hairpins
- Nuclear receptor coactivator interlocking domain [69124] (1)
3 helices, non-globular array; forms interlocked heterodimers with its targets
- Hermes dimerisation domain [140995] (1)
multihelical, intertwinned dimer of two 4-helical strings
- Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain [101488] (1)
5 helices, non-globular array; wraps around the N-terminal tail of its target
- Non-globular all-alpha subunits of globular proteins [48661] (14)
not a true fold
- Multiheme cytochromes [48694] (1)
variable number of helices and little beta structure; not a true fold
- All beta proteins [48724] (174)
- Immunoglobulin-like beta-sandwich [48725] (28)
sandwich; 7 strands in 2 sheets; greek-key
some members of the fold have additional strands
- Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (10)
sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
- Prealbumin-like [49451] (7)
sandwich; 7 strands in 2 sheets, greek-key
variations: some members have additional 1-2 strands to common fold
- HSP40/DnaJ peptide-binding domain [49492] (1)
sandwich; 6 strands in 2 sheets
- Penicillin-binding protein associated domain [69188] (1)
sandwich; 6 strands in 2 sheets
- alpha-Amylase inhibitor tendamistat [49497] (1)
sandwich; 6 strands in 2 sheets
- C-terminal domain of mollusc hemocyanin [81278] (1)
six-stranded beta-sandwich, jelly-roll/greek-key topology
- HPA-like [141085] (1)
sandwich, 6 strands in 2 sheets; jelly-roll (truncated); also includes the pending PCSK9 V domain-like superfamily (the C-terminal domains of 2p4e and 2pmw)
- L21p-like [141090] (1)
core: sandwich, 6 strands in 2 sheets
- Cupredoxin-like [49502] (2)
sandwich; 7 strands in 2 sheets, greek-key
variations: some members have additional 1-2 strands
- Ctag/Cox11 [110110] (1)
sandwich; 7 strands in 2 sheets, greek-key; permutation of the immunoglobulin-like fold
- Atu1913-like [141098] (1)
sandwich; 7 strands in two sheets, greek-key/jelly-roll; forms segment swapped dimers, swapping is probably facilitated by the helix insertion after strand 3
- C2 domain-like [49561] (5)
sandwich; 8 strands in 2 sheets; greek-key
- TRAF domain-like [49598] (1)
sandwich; 8 strands in 2 sheets; greek-key
- Neurophysin II [49605] (1)
sandwich; 8 strands in 2 sheets; meander
- N-utilization substance G protein NusG, insert domain [82003] (1)
sandwich; 8 strands in 2 sheets; meander
- Nucleoplasmin-like/VP (viral coat and capsid proteins) [88632] (7)
sandwich; 8 strands in 2 sheets; jelly-roll; some members can have additional 1-2 strands
characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies
- gamma-Crystallin-like [49694] (1)
sandwich; 8 strands in 2 sheets; greek-key
duplication: has internal pseudo twofold symmetry
- Lipase/lipooxygenase domain (PLAT/LH2 domain) [49722] (1)
sandwich; 8 strands in 2 sheets; complex topology
duplication: has weak internal pseudo twofold symmetry
- Calpain large subunit, middle domain (domain III) [49757] (1)
sandwich; 8 strands in 2 sheets; jelly-roll
- Supernatant protein factor (SPF), C-terminal domain [101575] (1)
sandwich; 8 strands in 2 sheets; jelly-roll; similarity to the Nucleoplasmin-like/VP fold
- Hypothetical protein TM1070 [89231] (1)
sandwich; 8 strands in 2 sheets; jelly-roll
- Olfactory marker protein [63696] (1)
sandwich; 8 strands in 2 sheets; jelly-roll
- HSP20-like chaperones [49763] (1)
sandwich; 8 strands in 2 sheets; greek-key
- Heat shock protein 70kD (HSP70), peptide-binding domain [100919] (1)
beta-sandwich: 8 strands in 2 sheets
- Ecotin, trypsin inhibitor [49771] (1)
sandwich; 8 strands in 2 sheets; complex topology with the crossing loops
- PEBP-like [49776] (1)
sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
- Ganglioside M2 (gm2) activator [63706] (1)
sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
- Nicotinic receptor ligand binding domain-like [63711] (1)
sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
- Beta-galactosidase LacA, domain 3 [117099] (1)
sandwich; 8 strands in 2 sheets
- Galactose-binding domain-like [49784] (1)
sandwich; 9 strands in 2 sheets; jelly-roll
- Viral protein domain [49817] (1)
sandwich; 9 strands in 2 sheets; jelly-roll; form trimers
- Calcium-mediated lectin [82025] (1)
sandwich; 9 strands in 2 sheets; greek-key
- Dextranase, N-terminal domain [101595] (1)
sandwich; 9 strands in 2 sheets; greek-key
- Smp-1-like [101600] (1)
sandwich; 9 strands in 2 sheets; greek-key/jelly-roll
- Superantigen (mitogen) Ypm [101605] (1)
sandwich; 9 strands in 2 sheets; jelly-roll
- ENV polyprotein, receptor-binding domain [49829] (1)
sandwich; 9 strands in 2 sheets; greek-key; contains a few helices in loop regions
- BTV NS2-like ssRNA-binding domain [110131] (1)
sandwich; 9 strands in 2 sheets; unusual topology with 2 crossover loops
- WSSV envelope protein-like [158973] (1)
beta-sandwich; 9 strands in 2 sheets; greek-key
- Virus attachment protein globular domain [49834] (1)
sandwich, 10 strands in 2 sheets; greek-key
- TNF-like [49841] (1)
sandwich, 10 strands in 2 sheets; jelly-roll
- CUB-like [49853] (3)
sandwich, 10 strands in 2 sheets; jelly-roll
- Hyaluronate lyase-like, C-terminal domain [49862] (1)
sandwich, 10 strands in 2 sheets; "folded meander"
- Cytolysin/lectin [63723] (1)
sandwich, 10 strands in 2 sheets;
- Putative glucosidase YicI, C-terminal domain [117124] (1)
sandwich; 10 strands in two sheets
- CsrA-like [117129] (1)
sandwich; 10 strands in 2 sheets; intertwined dimer (segment-swapped, 5-stranded greek-key sandwich?)
- Osmotin, thaumatin-like protein [49869] (1)
sandwich; 11 strands in 2 sheets
- SMAD/FHA domain [49878] (1)
sandwich; 11 strands in 2 sheets; greek-key
- Soluble secreted chemokine inhibitor, VCCI [49888] (1)
sandwich; 11 strands in 2 sheets; greek-key
- Baculovirus p35 protein [49893] (1)
sandwich; 14 strands in 2 sheets; greek-key
- Concanavalin A-like lectins/glucanases [49898] (1)
sandwich; 12-14 strands in 2 sheets; complex topology
- Supersandwich [49993] (3)
sandwich; 18 strands in 2 sheets
- Leukotriene A4 hydrolase N-terminal domain [63736] (1)
duplication: two beta-sandwiches of similar topologies are fused together in a single three beta-sheet domain
- EV matrix protein [50011] (1)
consists of two beta-sandwich domains of similar topologies
- Viral chemokine binding protein m3 [82045] (1)
consists of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds
- gp9 [50016] (1)
consists of two different beta-sandwich domains unrelated to other beta-sandwich folds
- Flagellar hook protein flgE [117142] (1)
consists of two different domains; d1: [complex fold made of bifurcated beta-sheets]; d2 (inserted into d1): [beta-sandwich; 8 strands in 2 sheets]
- ISP domain [50021] (1)
consists of two all-beta subdomains: conserved small domain has a rubredoxin-like fold; larger domain consists of 6 beta-stands packed in either sandwich of two 3-stranded sheets or closed barrel (n=6; S=8)
- Trm112p-like [158996] (1)
similar to the small domain of the ISP (scop_cf 50021)
- YopX-like [159005] (1)
consists of two domains: the N-terminal dimerisation domain of variable structure and the C-terminal domain with similarity to the SH3-like fold
- Obg-fold [82050] (1)
this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich
these regions form six left-handed collagen-like helices packed and H-bonded together
- SH3-like barrel [50036] (21)
barrel, partly opened; n*=4, S*=8; meander
the last strand is interrupted by a turn of 3-10 helix
- GroES-like [50128] (2)
contains barrel, partly opened; n*=4, S*=8; meander
- PDZ domain-like [50155] (1)
contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
- N-terminal domains of the minor coat protein g3p [50175] (1)
core: barrel, in some members open; n*=4, S*=8; meander
- Sm-like fold [50181] (5)
core: barrel, open; n*=4, S*=8; meander; SH3-like topology
- SspB-like [101737] (1)
core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
- Rof/RNase P subunit-like [101743] (1)
core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
- Hydrophobin II, HfbII [101750] (1)
core: barrel, closed; n=4, S=8; complex topology; helix-containing crossover connection
- Ribosomal protein L14 [50192] (1)
barrel, closed; n=5, S=8, meander
- OB-fold [50198] (16)
barrel, closed or partly opened n=5, S=10 or S=8; greek-key
- PRC-barrel domain [50345] (1)
core: barrel, partly opened; n*=5, S*=8; meander
- beta-Trefoil [50352] (8)
barrel, closed; n=6, S=12; and a hairpin triplet; meander
duplication: has internal pseudo threefold symmetry
- Reductase/isomerase/elongation factor common domain [50412] (4)
barrel, closed; n=6, S=10; greek-key
- Elongation factor/aminomethyltransferase common domain [50464] (2)
barrel, closed; n=6, S=10; greek-key
- Split barrel-like [50474] (3)
barrel; n=6, S=10; greek-key
- Phage tail proteins [69278] (1)
core: barrel; n=6, S=10; greek-key; topologically similar to the FMN-binding split barrel
- Surface presentation of antigens (SPOA) [101800] (1)
segment-swapped dimer forming two identical conjoint barrels (n=6, S=10) topologically similar to the FMN-binding split barrel
- FMT C-terminal domain-like [50485] (1)
barrel, open; n*=6, S*=10; greek-key
- Trypsin-like serine proteases [50493] (1)
barrel, closed; n=6, S=8; greek-key
duplication: consists of two domains of the same fold
- Replicase NSP9 [101815] (1)
barrel; n=6, S=8, greek-key; similar to one trypsin-like protease barrel
- mu transposase, C-terminal domain [50609] (1)
barrel; n=6, S=8, greek-key
- Domain of alpha and beta subunits of F1 ATP synthase-like [50614] (3)
barrel, closed; n=6, S=8; greek-key
- Small protein B (SmpB) [74981] (1)
barrel, closed; n=6, S=8, greek-key, partial similarity to the OB-fold
- Acid proteases [50629] (1)
barrel, closed; n=6, S=10, complex topology
- ValRS/IleRS/LeuRS editing domain [50676] (1)
core: barrel, closed; n=6, S=8; topology is similar to that of the acid proteases barrel
- Urease metallochaperone UreE, N-terminal domain [69286] (1)
barrel, closed; n=6, S=8; a crossover loop topology
- Double psi beta-barrel [50684] (2)
barrel, closed; n=6, S=10; complex topology with crossover (psi) loops
- Ribosomal protein L25-like [50714] (1)
barrel, closed; n=6, S=10; complex topology
- Core binding factor beta, CBF [50722] (1)
barrel, closed; n=6, S=10; meander; capped at both ends by alpha-helices
- NifT/FixU barrel-like [159202] (1)
barrel, closed, n=6, S=10; meander
- PH domain-like barrel [50728] (2)
barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
- Transcription factor IIA (TFIIA), beta-barrel domain [50783] (1)
barrel, closed; n=6, S=12; mixed beta-sheet
- Hcp1-like [141451] (1)
barrel, closed; n=6, S=12; contains extra, non-barrel strand 7 at the C-terminus
- YopT-like [159221] (1)
beta-sheet barrel, closed, n=6, S=12, capped at both ends by helices; intertwined dimer of beta-alpha-beta(2) subinits;
- Herpes virus serine proteinase, assemblin [50788] (1)
core: barrel, closed; n=7, S=8; complex topology
- PK beta-barrel domain-like [50799] (1)
barrel, closed; n=7, S=10; complex topology
- XRCC4, N-terminal domain [50808] (1)
barrel, closed; n=7, S=10; order: 1234765; strands 1 and 5 are parallel to each other
- HesB-like domain [89359] (1)
barrel, closed; n=7, S=10; complex topology
- Bacterial fluorinating enzyme, C-terminal domain [101851] (1)
barrel, closed; n=7, S=10; greek-key topology; one overside connection
- SPOC domain-like [100938] (1)
barrel, closed; n=7, S=10; complex topology
- BH3618-like [141456] (1)
barrel, closed; n=7, S=10; meander
- FAS1 domain [82152] (1)
core: barrel, closed; n=7, S=12; meander
- Lipocalins [50813] (1)
barrel, closed or opened; n=8, S=12; meander
- Streptavidin-like [50875] (8)
barrel, closed; n=8, S=10; meander
- FomD barrel-like [159233] (1)
barrel, closed; n=8, S=12; meander; similar topology to the AOC barrel-like fold (reversed to the lipocalin barrel topology)
- AOC barrel-like [141492] (2)
barrel, closed; n=8, S=10; meander; mirrored (reversed) topology to the Spreptavidin-like and Lipocalin-like folds
- AttH-like [159244] (1)
duplication: two flattened beta-barrels of lipocalin-like topology are orthogonally packed with a pseudo twofold symmetry
- Cyclophilin-like [50890] (1)
barrel, closed; n=8, S=10; complex topology
- Oncogene products [50903] (1)
barrel, closed; n=8, S=10; one overside connection
- L,D-transpeptidase catalytic domain-like [141522] (1)
barrel, closed; n=8, S=10; one overside connection
- Sortase [63816] (1)
barrel, closed; n=8, S=10; mixed sheet; two overside connections
- PTSIIA/GutA-like [141529] (1)
barrel, closed; n=8, S=12; mixed sheet; two overside connections; duplication: consists of two intertwinned structural repeats
- Mannose 6-phosphate receptor domain [50910] (1)
barrel, partly open; n*=8, S*=10; one psi loop
- triple barrel [50915] (1)
dimer of two non-identical subunits; forms two similar barrels, n=8, S=10 each, that are fused together with the formation of third barrel, n=6, S=8
- 4-bladed beta-propeller [50922] (1)
consists of four 4-stranded beta-sheet motifs; meander
- 5-bladed beta-propeller [50933] (3)
consists of five 4-stranded beta-sheet motifs; meander
- 6-bladed beta-propeller [50938] (11)
consists of six 4-stranded beta-sheet motifs; meander
- 7-bladed beta-propeller [50964] (14)
consists of seven 4-stranded beta-sheet motifs; meander
- 8-bladed beta-propeller [50997] (3)
consists of eight 4-stranded beta-sheet motifs; meander
also found in some members of the WD40-repeat superfamily
- Glycosyl hydrolase domain [51010] (1)
folded sheet; greek-key
- WW domain-like [51044] (3)
core: 3-stranded meander beta-sheet
- Head domain of nucleotide exchange factor GrpE [51063] (1)
small mixed beta-sheet, 4 "generalized" strands
- Coronavirus RNA-binding domain [110303] (1)
coiled antiparallel beta-sheet of 5 strands, order 51324; complex topology, crossing loops
- Ribonuclease domain of colicin E3 [63839] (1)
twisted meander beta-sheet of 6 strands
- NAC domain [101940] (1)
core: twisted 7-stranded beta-sheet (half-barrel)
- At5g01610-like [141561] (1)
contains large meander beta-sheet bent into a scoop-like shape
- Carbonic anhydrase [51068] (1)
single sheet; 10 strands
- LolA-like prokaryotic lipoproteins and lipoprotein localization factors [89391] (1)
11 stranded sheet partly folded in a corner-like structure filled with a few short helices
- YmcC-like [159269] (1)
12-stranded meander beta-sheet, folded into a deformed beta-barrel; topological similarity to the LolA-like fold (scop_cf 89391)
- Spiral beta-roll [159274] (1)
a large 15-stranded beta-sheet rolled about a single helix core; overlapping edges form a sandwich-like structure; topological similarity to the LolA-like fold (scop_cf 89391)
- Bacteriochlorophyll A protein [51080] (1)
single sheet; 16 strands; meander
- open-sided beta-meander [51086] (2)
single sheet formed by beta-hairpin repeats; exposed on both sides in the middle
- beta-Prism I [51091] (3)
consists of 3 4-stranded sheets; strands are parallel to the 3-fold axis
duplication: has internal pseudo threefold symmetry
- beta-Prism II [51109] (1)
consists of 3 4-stranded sheets; strands are perpendicular to the 3-fold axis
duplication: consists of two domains of this fold
- Single-stranded right-handed beta-helix [51125] (8)
superhelix turns are made of parallel beta-strands and (short) turns
- Single-stranded left-handed beta-helix [51160] (4)
superhelix turns are made of parallel beta-strands and (short) turns
- Double-stranded beta-helix [51181] (7)
one turn of helix is made by two pairs of antiparallel strands linked with short turns
has appearance of a sandwich of distinct architecture and jelly-roll topology
- Triple-stranded beta-helix [69348] (1)
(homo)trimer; each chain donates 3 beta-strands per turn of the helix
- Triple beta-spiral [51224] (1)
trimer formed by the interlocking beta-hairpin repeat units
- Trimeric adhesin [101998] (1)
trimer; contains two different beta-prism-like domains connected by an linker subdomain of less regular structure
- beta-hairpin stack [69359] (1)
Trp-rich beta-hairpin repeat units form helical structures of 3 units per turn
- Barrel-sandwich hybrid [51229] (4)
sandwich of half-barrel shaped beta-sheets
- beta-clip [51268] (7)
double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll
- PheT/TilS domain [56036] (1)
core: 3 layers; contains beta-sandwich of unusual topology
- C-terminal autoproteolytic domain of nucleoporin nup98 [82214] (1)
multisheet protein with a mixture of beta-sandwich and beta-prism features
- Pseudo beta-prism [141657] (1)
beta-sandwich with one regular beta-sheet and the other beta-sheet bent in the middle with a set of aligned beta-bulges
- SARS ORF9b-like [141665] (1)
complex dimeric fold with three intersubunit beta-sheets packed around a single core
- Adsorption protein p2 [89427] (1)
multisheet protein containing partial beta-propeller and beta-sandwich regions
- Baseplate structural protein gp8 [89432] (1)
multisheet protein with a mixture of beta-sandwich and beta-barrel features
- Hedgehog/intein (Hint) domain [51293] (1)
complex fold made of five beta-hairpin units and a b-ribbon arc
- LexA/Signal peptidase [51305] (1)
complex fold made of several coiled beta-sheets; contains an SH3-like barrel
- Cloacin translocation domain [69368] (1)
complex fold made of several coiled beta-sheets
- Mss4-like [51315] (1)
complex fold made of several coiled beta-sheets
- Cyanovirin-N [51321] (1)
complex fold
- Tp47 lipoprotein, N-terminal domain [82219] (1)
complex fold; consists of two intertwined subdomains
- Methuselah ectodomain [63876] (1)
complex fold
- Head-binding domain of phage P22 tailspike protein [51326] (1)
complex fold made of bifurcated and partly folded beta-sheet
- E2 regulatory, transactivation domain [51331] (1)
complex fold made of bifurcated and coiled beta-sheets
- MoeA N-terminal region -like [63881] (1)
complex fold made of bifurcated and coiled b-sheets
- MOSC N-terminal domain-like [141672] (1)
complex fold; comprises a beta-hairpin and a meander 3-stranded sheet packed against beta-barrel: closed, n=5, S=8; contains three short helices
- MAL13P1.257-like [141677] (1)
complex fold; duplication: consists of two intertwinned structural repeats related by pseudo dyad
- Composite domain of metallo-dependent hydrolases [51337] (1)
pseudobarrel; mixed sheet of 7 strand folded upon itself and "buckled" by two beta-turns
- Epsilon subunit of F1F0-ATP synthase N-terminal domain [51343] (1)
pseudobarrel: sandwich of two sheets packed at a positive interstrand angle and interconnected with many short turns
- N-terminal domain of MutM-like DNA repair proteins [81625] (1)
pseudobarrel; capped on both ends by alpha-helices
- Hypothetical protein YojF [89441] (1)
pseudobarrel; capped at one end by an alpha-helix
- DNA-binding pseudobarrel domain [101935] (1)
core: barrel, open; n=7, S*=10; capped with helices at both ends; partial similarity to the AbrB/MazE/MraZ-like fold (scop_cf 89446)
- Double-split beta-barrel [89446] (2)
pseudobarrel; capped on both ends by alpha-helices
- PUA domain-like [88696] (1)
pseudobarrel; mixed folded sheet of 5 strands; order 13452; strand 1 and 3 are parallel to each other
- AXH domain [102030] (1)
pseudobarrel; some similarity to OB-fold
- FimD N-terminal domain-like [141728] (1)
pseudo barrel, capped by an alpha-helix; some topological similarity to the PRC-barrel domain (scop_sf 50346) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
- HisI-like [141733] (1)
pseudo barrel, capped by an alpha-helix; contains a beta-triangle structure on one side; some topological similarity to the Ribosomal protein L25-like fold (scop_cf 50714) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
- MFPT repeat-like [141738] (1)
consists of two similar pseudo barrel subdomains with structural similarity to a circularly permuted SAND domain (scop_fa 63764)
- P-domain of calnexin/calreticulin [63886] (1)
non-globular proline-rich hairpin
- Alpha and beta proteins (a/b) [51349] (147)
Mainly parallel beta sheets (beta-alpha-beta units)
- TIM beta/alpha-barrel [51350] (33)
contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites
- NAD(P)-binding Rossmann-fold domains [51734] (1)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar
- FAD/NAD(P)-binding domain [51904] (1)
core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
- Nucleotide-binding domain [51970] (1)
3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
- MurCD N-terminal domain [51983] (1)
3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; incomplete Rossmann-like fold; binds UDP group
- 7-stranded beta/alpha barrel [51988] (3)
variant of beta/alpha barrel; parallel beta-sheet barrel, closed, n=7, S=8; strand order 1234567; some members may have fewer strands
- PFL-like glycyl radical enzymes [51997] (1)
contains: barrel, closed; n=10, S=10; accommodates a hairpin loop inside the barrel
- The "swivelling" beta/beta/alpha domain [52008] (10)
3 layers: b/b/a; the central sheet is parallel, and the other one is antiparallel; there are some variations in topology
this domain is thought to be mobile in most multi-domain proteins known to contain it
- Barstar-like [52037] (2)
2 layers, a/b; parallel beta-sheet of 3 strands, order 123
- MurF and HprK N-domain-like [63417] (2)
core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1234; structural similarity of the MurF and HprK extends beyond the core.
- Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [52046] (3)
2 curved layers, a/b; parallel beta-sheet; order 1234...N; there are sequence similarities between different superfamilies
- Ribosomal proteins L15p and L18e [52079] (1)
core: three turns of irregular (beta-beta-alpha)n superhelix
- SpoIIaa-like [52086] (2)
core: 4 turns of a (beta-alpha)n superhelix
- ClpP/crotonase [52095] (1)
core: 4 turns of (beta-beta-alpha)n superhelix
- BRCT domain [52112] (1)
3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
- Lumazine synthase [52120] (1)
3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
- Uracil-DNA glycosylase-like [52140] (1)
3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
- Creatininase [102214] (1)
3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
- DNA polymerase III psi subunit [102219] (1)
3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
- Initiation factor IF2/eIF5b, domain 3 [52155] (1)
3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
- Aminoacid dehydrogenase-like, N-terminal domain [53222] (1)
core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134
- Toprim domain [110454] (1)
3 layers, a/b/a; parallel beta-sheet of 4 strands, order 2134
- AtpF-like [159467] (1)
3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 2134
- Ribosomal protein L13 [52160] (1)
3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 3214
- Ribosomal protein L4 [52165] (1)
3 layers, a/b/a; core: parallel beta-sheet of 4 strands, order 1423
- Nqo1 FMN-binding domain-like [142018] (1)
3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214
- Flavodoxin-like [52171] (15)
3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345
- Methylglyoxal synthase-like [52334] (1)
3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145
- Ferredoxin reductase-like, C-terminal NADP-linked domain [52342] (1)
3 layers, a/b/a; parallel beta-sheet of 5 strands, order 32145
- Adenine nucleotide alpha hydrolase-like [52373] (3)
core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145
- Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [52417] (1)
3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
- Cryptochrome/photolyase, N-terminal domain [52424] (1)
3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like
- DsrEFH-like [75168] (1)
3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 43215
- PIN domain-like [88722] (1)
3 layers, a/b/a; core: parallel beta-sheet of 5 strands, order 32145
- Ribose/Galactose isomerase RpiB/AlsB [89622] (1)
3 layers: a/b/a, core: parallel beta-sheet of 5 strands, order 21354; topological similarity to a part of the arginase/deacetylase fold
- EreA/ChaN-like [159500] (1)
Core: 3 layers: a/b/a; parallel beta-sheet of 5 strands, order:51423;
- alpha/beta knot [75216] (1)
core: 3 layers: a/b/a, parallel beta-sheet of 5 strands, order 21435; contains a deep trefoil knot
- PreATP-grasp domain [52439] (1)
3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
possible rudiment form of Rossmann-fold domain
- DHS-like NAD/FAD-binding domain [52466] (1)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
- Tubulin nucleotide-binding domain-like [52489] (1)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
- Isochorismatase-like hydrolases [52498] (1)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
- Dipeptide transport protein [63991] (1)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; also contains a C-terminal alpha+beta subdomain
- Homo-oligomeric flavin-containing Cys decarboxylases, HFCD [52506] (1)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
- HAD-like [56783] (1)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
- NagB/RpiA/CoA transferase-like [100949] (1)
core: 3 layers: a/b/a; parallel or mixed beta-sheet of 6 strands, order 321456
- Hypothetical protein MTH777 (MT0777) [75180] (1)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
- Thiamin pyrophosphokinase, catalytic domain [63998] (1)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 432156
- Undecaprenyl diphosphate synthase [64004] (1)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 342156
- F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) [102323] (1)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213456
- Thiamin diphosphate-binding fold (THDP-binding) [52517] (1)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
- P-loop containing nucleoside triphosphate hydrolases [52539] (1)
3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
- PTS IIb component [52727] (1)
3 layers: a/b/a, parallel beta-sheet of 6 strands, order 324156
- DNA polymerase III chi subunit [102399] (1)
3 layers, a/b/a; parallel beta-sheet of 7 strands, order 7165243
- Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) [52732] (1)
3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3214567
- CofD-like [142337] (1)
3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3214567; topological similarity to the CobT-like fold (scop_cf 52732)
- MCP/YpsA-like [102404] (1)
3 layers: a/b/a, parallel beta-sheet of 7 strands, order 4321567
- Methylesterase CheB, C-terminal domain [52737] (1)
3 layers: a/b/a, parallel beta-sheet of 7 strands, order 3421567
- Subtilisin-like [52742] (1)
3 layers: a/b/a, parallel beta-sheet of 7 strands, order 2314567; left-handed crossover connection between strands 2 & 3
- Indigoidine synthase A-like [110580] (1)
core: 3 layers, a/b/a; parallel beta-sheet of 7 strands, order 2134756
- Arginase/deacetylase [52767] (1)
3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456
- Alpha-2,3/8-sialyltransferase CstII [102413] (1)
3 layers: a/b/a; parallel beta-sheet of 8 strands, order 54321678
- Cell-division inhibitor MinC, N-terminal domain [64042] (1)
beta(2)-(alpha-beta)2-beta; 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 1 & 5 are antiparallel to the rest
- DTD-like [69499] (1)
beta(2)-(alpha-beta)2-beta(3); 3 layers, a/b/b; some topological similarity to the N-terminal domain of MinC
- CoA-dependent acyltransferases [52776] (1)
core: 2 layers, a/b; mixed beta-sheet of 6 strands, order 324561; strands 3 & 6 are antiparallel to the rest
- Phosphotyrosine protein phosphatases I-like [52787] (2)
3 layers: a/b/a; parallel beta-sheet of 4 strands, order 2134
- (Phosphotyrosine protein) phosphatases II [52798] (1)
core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
- Rhodanese/Cell cycle control phosphatase [52820] (1)
3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451
- Thioredoxin fold [52832] (2)
core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest
- Peptidyl-tRNA hydrolase II [102461] (1)
3 layers: a/b/a; mixed beta-sheet of 4 strands, order 2143, strand 4 is antiparallel to the rest
- TK C-terminal domain-like [52921] (1)
3 layers: a/b/a; mixed beta-sheet of 5 strands, order 13245, strand 1 is antiparallel to the rest
- Pyruvate kinase C-terminal domain-like [52934] (2)
3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145, strand 5 is antiparallel to the rest
- Anticodon-binding domain-like [52953] (6)
3 layers: a/b/a; mixed beta-sheet of five strands, order 21345; strand 4 is antiparallel to the rest
- MTH938-like [64075] (1)
core: 3 layers, b+a/b/a ; the central mixed sheet of 5 strands: order 21534; strand 2 is antiparallel to the rest
- Restriction endonuclease-like [52979] (4)
core: 3 layers, a/b/a; mixed beta-sheet of 5 strands, order 12345; strands 2 &, in some families, 5 are antiparallel to the rest
- Resolvase-like [53040] (2)
Core: 3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest
- PTS system fructose IIA component-like [53061] (1)
3 layers: a/b/a; mixed beta-sheet of 5 strands, order 21345; strand 5 is antiparallel to the rest
- Ribonuclease H-like motif [53066] (7)
3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest
- Phosphorylase/hydrolase-like [53162] (8)
core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops
- Molybdenum cofactor biosynthesis proteins [53217] (1)
3 layers: a/b/a; mixed beta-sheet of 5 strands; order: 21354, strand 5 is antiparallel to the rest; permutation of the Phosphorylase/hydrolase-like fold
- CobE/GbiG C-terminal domain-like [159663] (1)
3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32154; strand 5 is antiparallel to the rest
- CbiG N-terminal domain-like [159671] (1)
3 layers: a/b/a; mixed beta-sheet of 6 strands, order 213456, strand 5 is antiparallel to the rest
- Bacterial fluorinating enzyme, N-terminal domain [102521] (1)
3 layers: a/b/a; mixed beta-sheet of 6 strands; order: 213546, strand 5 is antiparallel to the rest; topological similarity to the MogA-like family fold
- Caspase-like [52128] (1)
3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest
- Macro domain-like [52948] (1)
3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest
- MurD-like peptide ligases, peptide-binding domain [53243] (1)
3 layers: a/b/a; mixed beta-sheet of 6 strands, order 126345; strand 1 is antiparallel to the rest
- Phosphoglycerate mutase-like [53253] (1)
core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 324156; strand 5 is antiparallel to the rest
- PRTase-like [53270] (1)
core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
- vWA-like [53299] (1)
core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
- Pyruvate-ferredoxin oxidoreductase, PFOR, domain III [53322] (1)
3 layers: a/b/a; mixed beta-sheet of 6 strands, order 231456; strand 3 is antiparallel to the rest
- RbsD-like [102545] (1)
3 layers: a/b/a; mixed beta-sheet of 6 strands, order 251634; strand 6 is antiparallel to the rest
- FabD/lysophospholipase-like [52150] (1)
core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 432156; strand 4 is antiparallel to the rest
- L-sulfolactate dehydrogenase-like [89732] (1)
core: 3 layers, a/b/a; mixed sheet of 7 strands, order 1237456; strands 1, 6 and 7 are antiparallel to the rest
- Formyltransferase [53327] (1)
3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214567; strand 6 is antiparallel to the rest
- S-adenosyl-L-methionine-dependent methyltransferases [53334] (1)
core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
- LmbE-like [102587] (1)
3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest; topological similarity to SAM-dependent methyltransferases
- PLP-dependent transferase-like [53382] (3)
main domain: 3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3245671; strand 7 is antiparallel to the rest
- Nucleotide-diphospho-sugar transferases [53447] (1)
3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3214657; strand 6 is antiparallel to the rest
- RibA-like [142694] (1)
3 layers: a/b/a; mixed beta-sheet of 7 strands, order 1235467, strands 1 and 3 are antiparallel to the rest; partial topological similarity to some alpha/beta hydrolases (scop_cf 53473)
- Activating enzymes of the ubiquitin-like proteins [69571] (1)
3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
- alpha/beta-Hydrolases [53473] (1)
core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest
- Nucleoside hydrolase [53589] (1)
core: 3 layers, a/b/a ; mixed beta-sheet of 8 strands, order 32145687; strand 7 is antiparallel to the rest
- Dihydrofolate reductase-like [53596] (1)
3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
- Ribokinase-like [53612] (3)
core: 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 21345678, strand 7 is antiparallel to the rest
potential superfamily: members of this fold have similar functions but different ATP-binding sites
- YjeF N-terminal domain-like [64152] (1)
3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 32145678; strand 8 is antiparallel to the rest
- Carbamate kinase-like [53632] (1)
3 layers: a/b/a; mixed (mainly parallel) beta-sheet of 8 strands, order 34215786; strand 8 is antiparallel to the rest
- 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain [64157] (1)
core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 45321678, strands 4 and 5 are antiparallel to the rest
- Alkaline phosphatase-like [53648] (1)
core:3 layers: a/b/a; mixed beta-sheet of 8 strands, order 43516728, strand 7 is antiparallel to the rest
- TTHA0583/YokD-like [110709] (1)
3 layers: a/b/a; mixed beta-sheet of 8 strands, order 78612354; strands 3, 4 and 8 are antiparallel to the rest
- Glycerol-3-phosphate (1)-acyltransferase [69592] (1)
3 layers: a/b/a; mixed beta-sheet of 9 strands, order 918736452; strands 1, 2 and 8 are antiparallel to the rest
- AraD/HMP-PK domain-like [53638] (1)
3 layers: a/b/a; mixed (mostly antiparallel) beta-sheet of 9 strands, order 432159876; left-handed crossover between strands 4 and 5
- SurE-like [64166] (1)
3 layers: a/b/a; mixed beta-sheet of 9 strands, order 342156798; strands 3, 8 and 9 are antiparallel to the rest; left-handed crossover connection between strands 6 and 7
- YerB-like [159773] (1)
3 layers: b/b/a; central mixed beta-sheet of 9 strands, order 541329678; strands 3 and 7 are antiparallel to the rest; an unusual "over the other end" connection between strands 3 and 4
- CdCA1 repeat-like [159778] (1)
contains two parallel beta-strands of four strands each; the sheets contact each other with edges at a right angle
- Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1)
consists of two intertwined (sub)domains related by pseudo dyad; duplication
3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
- Amidase signature (AS) enzymes [75303] (1)
possible duplication: the topologies of N- and C-terminal halves are similar; 3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213549A867 (A=10); strands from 5 to 9 are antiparallel to the rest
- ATC-like [53670] (2)
consists of two similar domains related by pseudo dyad; duplication
core: 3 layers, a/b/a, parallel beta-sheet of 4 strands, order 2134
- Tryptophan synthase beta subunit-like PLP-dependent enzymes [53685] (1)
consists of two similar domains related by pseudo dyad; duplication
core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214
- SIS domain [53696] (1)
3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345
- Formate dehydrogenase/DMSO reductase, domains 1-3 [53705] (1)
contains of two similar intertwined domains related by pseudo dyad; duplication
core: 3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451
- ALDH-like [53719] (1)
consists of two similar domains with 3 layers (a/b/a) each; duplication
core: parallel beta-sheet of 5 strands, order 32145
- NadA-like [142753] (1)
duplication; consists of three similar domains related by pseudo threefold symmetry; 3 layers, a/b/a; parallel beta sheet, order: 2134
- Aconitase iron-sulfur domain [53731] (1)
consists of three similar domains with 3 layers (a/b/a) each; duplication
core: parallel beta-sheet of 5 strands, order 32145
- Phosphoglucomutase, first 3 domains [53737] (1)
consists of three similar domains with 3 layers (a/b/a) each; duplication
core: mixed beta-sheet of 4 strands, order 2134, strand 4 is antiparallel to the rest
- FucI/AraA N-terminal and middle domains [53742] (1)
consists of two domains of similar topology, 3 layers (a/b/a) each
Domain 1 (1-173) has parallel beta-sheet of 5 strands, order 21345
Domain 2 (174-355) has parallel beta-sheet of 4 strands, order 2134
- YgbK-like [142763] (1)
consists of two domains with partial topological similarity to the P-loop kinases but without the P-loop motif; the domain association results in the formation of a single mixed beta-sheet of 15 strands
- Phosphoglycerate kinase [53747] (1)
consists of two non-similar domains, 3 layers (a/b/a) each
Domain 1 has parallel beta-sheet of 6 strands, order 342156
Domain 2 has parallel beta-sheet of 6 strands, order 321456
- UDP-Glycosyltransferase/glycogen phosphorylase [53755] (1)
consists of two non-similar domains with 3 layers (a/b/a) each
domain 1: parallel beta-sheet of 7 strands, order 3214567
domain 2: parallel beta-sheet of 6 strands, order 321456
- Glutaminase/Asparaginase [53773] (1)
consists of two non-similar alpha/beta domains, 3 layers (a/b/a) each
Domain 1 has mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest; left-handed crossover connection between strands 4 and 5
Domain 2 has parallel beta-sheet of 4 strands, order 1234
- Phosphofructokinase [53783] (1)
consists of two non-similar domains, 3 layers (a/b/a) each
Domain 1 has mixed sheet of 7 strands, order 3214567; strands 3 & 7 are antiparallel to the rest
Domain 2 has parallel sheet of 4 strands, order 2314
- Tetrapyrrole methylase [53789] (1)
consists of two non-similar domains
Domain 1 has parallel sheet of 5 strands, order 32415
Domain 2 has mixed sheet of 5 strands, order 12534; strands 4 & 5 are antiparallel to the rest
- GckA/TtuD-like [82543] (1)
consists of two non-similar domains
Domain 1 has parallel sheet of 6 strands, order 321456, Rossmann-like topology
Domain 2 has mixed sheet of 6 strands, order 126345; strands 5 and 6 are antiparallel to the rest; some similarity to CbiF Domain 2
- DAK1/DegV-like [82548] (1)
2 different domains; d1: [core: 3 layers, a/b/a; parallel sheet of 5 strands, order: 2134]; D2: [2 layers, a/b; mixed sheet of 6 strands, order 321645; strands 2 and 6 are antiparallel to the rest]
- DHH phosphoesterases [64181] (1)
consists of two non-similar domains
Domain 1 has parallel sheet of 6 strands, order 321456
Domain 2 has mixed sheet of 5 strands, order 12345; strands 1 & 4 are antiparallel to the rest
- Glycerate kinase I [110737] (1)
consists of two different alpha/beta domains; (1) of the Flavodoxin-like fold (scop_cf 52171); (2) similar to the Restriction endonuclease-like fold (scop_cf 52979), inserted into domain 1
- PEP carboxykinase-like [53794] (1)
contains a P-loop NTP-binding motif; mixed beta-sheet folds into a barrel-like structure with helices packed on one side
- PEP carboxykinase N-terminal domain [68922] (1)
contains mixed beta-sheets; topology is partly similar to that of the catalytic C-terminal domain
- Chelatase-like [53799] (3)
duplication: tandem repeat of two domains; 3 layers (a/b/a); parallel beta-sheet of 4 strands, order 2134
- HemD-like [69617] (1)
duplication: consists of two similar 'swapped' domain with 3 layers (a/b/a) each; parallel beta-sheet of 5 strands, order 21345
- CAC2185-like [142794] (1)
consists of two non-similar domains, 3 layers (a/b/a) each; d1 has parallel sheet of 4 strands, order 2134; d2 has parallel sheet of 5 strands, order 21345, and antiparallel meander sheet of 3 strands
- Periplasmic binding protein-like I [53821] (1)
consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
parallel beta-sheet of 6 strands, order 213456
- Periplasmic binding protein-like II [53849] (1)
consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
mixed beta-sheet of 5 strands, order 21354; strand 5 is antiparallel to the rest
- Thiolase-like [53900] (1)
consists of two similar domains related by pseudo dyad; duplication
3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32451; strand 5 is antiparallel to the rest
- NIF3 (NGG1p interacting factor 3)-like [102704] (1)
consist of two intertwined domains; duplication: contains two structural repeats of alpha-beta-(beta-alpha)3 motif with mixed beta-sheet, order: 1432, strand 1 is antiparallel to the rest
- Fe-only hydrogenase [53919] (1)
consist of two intertwined domains; contains partial duplication
- ComB-like [142822] (1)
contains of two similar intertwined domains related by pseudo dyad; duplication; core: 3 layers: a/b/a; parallel beta-sheet of 4 strands, order 1423
- CoA-transferase family III (CaiB/BaiF) [89795] (1)
consist of two different alpha/beta domains; N-terminal domain has a SurE-like topology with a left-handed beta-alpha-beta unit
- Cytidine deaminase-like [53926] (2)
core: alpha-beta(2)-(alpha-beta)2; 3 layers (a/b/a); mixed beta-sheet of 4 strands, order 2134; strand 1 is antiparallel to the rest
- Alpha and beta proteins (a+b) [53931] (376)
Mainly antiparallel beta sheets (segregated alpha and beta regions)
- Microbial ribonucleases [53932] (1)
single helix packs against antiparallel beta-sheet
- Lysozyme-like [53954] (1)
common alpha+beta motif for the active site region
- Cysteine proteinases [54000] (1)
consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
- His-Me finger endonucleases [54059] (1)
core: (alpha)-beta-omega_loop-beta-alpha; embeded in larger different structures
- RNase A-like [54075] (1)
contains long curved beta-sheet and 3 helices
- EndoU-like [142876] (1)
comprises several helices and two three-stranded antiparallel beta-sheets; similar architecture to the RNase A-like fold (scop_cf 54075)
- Prion-like [54097] (1)
beta-alpha-beta-alpha(2); antiparallel beta-ribbon
- LysM domain [54105] (1)
beta-alpha(2)-beta; antiparallel strands
- gpW/XkdW-like [64209] (2)
alpha-beta(2)-alpha; antiparallel hairpin
- Hypothetical protein MTH677 [110782] (1)
alpha-beta(2)-alpha; 2 layers a/b; antiparallel beta-hairpin
- GTF2I-like repeat [117772] (1)
alpha(2)-beta-alpha-beta-alpha; 2 layers: a/b; antiparallel beta-ribbon
- Urease, gamma-subunit [54110] (1)
alpha(3)-beta(2); antiparallel hairpin
- IL8-like [54116] (2)
beta(3)-alpha
- DNA-binding domain [54170] (1)
beta(3)-alpha; 2 layers: alpha/beta
- Penicillin-binding protein 2x (pbp-2x), c-terminal domain [54183] (1)
alpha1-beta3; 2 layers: alpha/beta; order 132
- Dodecin subunit-like [88797] (6)
beta-alpha-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 132
- Ribosomal proteins S24e, L23 and L15e [54188] (1)
beta-(alpha)-beta-alpha-beta(2); 3 layers: alpha/beta/alpha; antiparallel beta-sheet: order 1243
- Ribosome binding domain-like [100965] (2)
beta-(2)-alpha(2)-beta(2); 2 layers: beta/alpha; antiparallel beta-sheet: order 1243; topological similarity to the common core of ribosomal proteins L23 and L15e
- TFB5-like [142896] (1)
beta-alpha-beta(2)-alpha; 2 layers, a/b; antiparallel sheet, order: 132; dimerises in solution (PDB 2jnj) via extended N-terminal strand
- Obg GTP-binding protein C-terminal domain [102740] (1)
beta-(2)-alpha(3)-beta(2); 2 layers: beta/alpha; mixed beta-sheet: order 1234; strands 2 and 3 a parallel to each other
- HIT-like [54196] (2)
alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha
- Secretion chaperone-like [69634] (5)
alpha-beta(3)-alpha-beta(2)-alpha; 2 layers: alpha/beta
- DNA-binding domain of intron-encoded endonucleases [64495] (1)
beta(2)-alpha(2)-beta; 2 layers; 3-stranded antiparallel beta-sheet, order 213; HTH motif; also includes the extra N-terminal, DNA minor groove-binding helix
- MotA C-terminal domain-like [69651] (1)
alpha-beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta
- YktB/PF0168-like [142912] (1)
alpha-beta(4)-alpha-beta(2)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order: 1234756; half-barrel shape; topological similarity to the MotA C-terminal domain-like fold (scop_cf 69651) and the Secretion chaperone-like fold (scop_cf 69634)
- Mago nashi protein [89816] (1)
beta(4)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, order: 651234
- WGR domain-like [142920] (1)
beta(4)-alpha-X-beta; 2 layers, a/b; antiparallel beta-sheet, order 51234; the beta-hairpin insetrion in strand 1 results in the formation of a beta-triangle structure
- PH1570-like [159901] (1)
duplication: two beta(4)-alpha structural repeats, related by pseudo twofold symmetry; two extra helices in the linker region; single 8-standed antiparallel beta-sheet, order: 12348765
- Ribosomal protein S5 domain 2-like [54210] (1)
core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover
- beta-Grasp (ubiquitin-like) [54235] (14)
core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
- MM3350-like [159940] (1)
beta(2)-alpha-beta(4); antiparallel beta-sheet; order: 216534; similar to a ubiquitin-like fold with the extra C-terminal strand inserted in the middle of the beta-sheet
- WWE domain [117838] (1)
beta(2)-alpha-beta(4); antiparallel folded beta-sheet (half-barrel), order 216543
- FAD-linked reductases, C-terminal domain [54372] (1)
alpha+beta sandwich
- Cystatin-like [54402] (7)
Core: alpha-beta(4); helix packs against coiled antiparallel beta-sheet
- Nuclease A inhibitor (NuiA) [82601] (1)
alpha-beta-alpha-beta-alpha(2)-beta(3); antiparallel beta-sheet; order: 15432
- Colicin D/E5 nuclease domain [102823] (1)
alpha(2)-beta(4)-alpha, 2 layers: alpha/beta, antiparallel beta sheet, meander
- RelE-like [143010] (1)
beta-alpha(2)-beta(4), 2 layers; a/b, antiparallel beta-sheet; order 15432
- Hypothetical protein SAV1430 [110835] (1)
beta(3)-alpha-beta(2)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet, order: 12543
- Ns1 effector domain-like [143020] (1)
beta-X-beta(5)-alpha-beta-alpha; 2 layers: a/b; bifurcated beta-sheet; order 23654[1,7]
- YbaB-like [82606] (1)
core: alpha-beta(3)-alpha, 2 layers:alpha/beta, three-stranded antiparallel beta sheet, strand order 123
- Kinetochore globular domain-like [143025] (1)
core: alpha-beta(3)-alpha; variant: alpha-beta(4)-alpha(2)
- L35p-like [143033] (1)
core: alpha-beta(3)-alpha; 2layers a/b
- Cell division protein ZapA-like [102828] (1)
core: beta(2)-alpha(2), 2 layers: alpha/beta; long C-terminal helix forms dimeric parallel and tetrameric antiparallel coiled coils
- ssDNA-binding transcriptional regulator domain [54446] (1)
helix-swapped dimer of beta(4)-alpha motifs
- Photosystem I subunit PsaD [64233] (1)
beta-BETA(2)-beta-alpha-beta(2); antiparallel sheet: order 2134 packed against helix and BETA-hairpin on the same side; irregular C-terminal tail
- GINS/PriA/YqbF domain [160058] (1)
beta(4)-alpha-beta; 3-stranded antiparallel beta-sheet (strands 4,1 and 5) are covered on the same side by the helix and beta hairpin of strands 2 and 3; similarity to the L9 N-domain-like fold (scop_cf 55657) and the PsaD fold (scop_sf 64243)
- MHC antigen-recognition domain [54451] (1)
dimeric
- UBC-like [54494] (1)
alpha-beta(4)-alpha(3); core: meander beta-sheet plus one helix 2
- SAND domain-like [63762] (1)
core: three short helices packed against a barrel-like beta-sheet; some similarity to the SH3-like fold
- NRDP1 C-terminal domain-like [160087] (1)
alpha-beta-alpha(3)-beta(3); a pseudo barrel beta-sheet of an SH3-like topology, surrounded by helices
- Coronavirus NSP8-like [143075] (1)
core: alpha-beta(2)-alpha-beta(4)-alpha-beta; bifurcated barrel-like beta-sheet
- ParB/Sulfiredoxin [110848] (1)
beta*-alpha-beta(2)-alpha-beta-alpha; mixed beta sheet forms a partly open barrel: (n*=4, S*=8)
- Gamma-glutamyl cyclotransferase-like [110856] (1)
beta-alpha-beta(4)-alpha-beta(2); contains beta-sheet barrel (n=5, S=8)
- BB1717-like [143080] (1)
complex fold with a bifurcated beta-sheet structure surrounded by helices; contains beta-sheet barrel, closed (n=5, S=8)
- SARS Nsp1-like [160098] (1)
complex alpha+beta fold; contains mixed beta-sheet barrel, n=6, S=10
- Acetoacetate decarboxylase-like [160103] (1)
complex fold: contains a 3-layer beta-sheet structure, which is folded in two conjoint barrels capped by helices; one rounded barrel has 7 strands, the other flattened barrel has 9 strands
- AF0104/ALDC/Ptd012-like [117855] (1)
duplication: consists of two similar beta-alpha-beta(4) motifs
- NSFL1 (p97 ATPase) cofactor p47, SEP domain [102847] (1)
beta(3)-alpha(2)-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other
- TTHA1013/TTHA0281-like [143099] (1)
beta(3)-alpha-beta; 2 layers; mixed beta-sheet, order 4123, strands 1 and 4 are parallel to each other; topological similarity to the SEP domain fold (scop_cf 102847); dimerises via the long C-terminal strand with the formation of a single beta-sheet
- YegP-like [160112] (1)
comprises two subunits or tandem repeats of beta(3)-alpha-beta motifs; these assemble with the formation of a single beta-sheet and swapping of the C-terminal strands
- Diaminopimelate epimerase-like [54505] (1)
mixed beta-sheet folds into a barrel (n=8, S=14) around the central helix
- GFP-like [54510] (1)
beta-sheet folds into a barrel (n=11, S=14) around the central helix
- Tubby C-terminal domain-like [54517] (1)
beta-sheet folds into a barrel (n=12, S=12) around the central helix
- Pili subunits [54522] (1)
contains very long N-terminal helix, which end is packed against beta-sheet
- Mitochondrial glycoprotein MAM33-like [54528] (1)
core: beta(7)-alpha(2); N- and C-terminal extensions form a coiled coil subdomain
- NAP-like [143112] (1)
core: central meander 4-stranded beta-sheet (order: 1234) transversed by a C-terminal helix
- Polo-box domain [82614] (1)
beta(6)-alpha; antiparallel beta-sheet, meander
- mRNA decapping enzyme DcpS N-terminal domain [102859] (1)
beta(3)-alpha-beta(3)-alpha; 3 layers a/b/a
- Inhibitor of vertebrate lysozyme, Ivy [89871] (1)
alpha(2)-beta(5)-alpha(2); 3 layers a/b/a; meander beta-sheet
- FKBP-like [54533] (3)
core: beta(2)-alpha-beta(2); antiparallel beta-sheet
- Ribosomal protein S16 [54564] (1)
beta(4)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet, order: 51234
- Ribosomal protein S19 [54569] (1)
alpha-beta-X-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 123
- YefM-like [143119] (1)
core: beta-alpha(2)-beta(2)-alpha; mixed beta-sheet, order:123, strands 1 and 2 are parallel; forms compact dimer with a single beta-sheet;
- Ribosomal protein L31e [54574] (1)
beta-alpha-beta-(alpha)-beta(2); 2 layers: alpha/beta; mixed beta-sheet, order: 1342
- Allophycocyanin linker chain (domain) [54579] (1)
beta(2)-alpha-beta; 2 layers: alpha/beta
- Cdc48 domain 2-like [54584] (1)
beta-alpha-beta(3); 2 layers: alpha/beta
- Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1)
beta-alpha-beta(3); 2 layers: alpha/beta
- Chromosomal protein MC1 [102874] (1)
beta(2)-alpha-beta(3); 2 layers: alpha/beta
- CPE0013-like [160147] (1)
beta(2)-alpha-beta(3); mixed, mostly antiparallel beta-sheet, folded in a half-barrel; order:31254; strand 3 is parallel to strand 1 and is shorter than the rest
- beta-hairpin-alpha-hairpin repeat [74651] (2)
multiple repeats of beta(2)-alpha(2) motif
- Proguanylin [89889] (1)
beta(2)-alpha(3)-beta; two layers: alpha/beta; antiparallel sheet: order 213
- SecB-like [54610] (1)
beta(4)-alpha(2); two layers: alpha/beta; antiparallel sheet: order 1432
- MesJ substrate recognition domain-like [82828] (1)
beta-alpha(2)-beta(3); 2 layers: a/b; antiparallel beta-sheet, order:1432
- FYSH domain [89894] (1)
beta(2)-alpha(2)-beta(2)-alpha-beta; two layers: alpha/beta; antiparallel sheet: order 51234
- VSV matrix protein [75403] (1)
beta-alpha(2)-beta(4)-alpha-beta(2); two layers: alpha/beta; bifurcated coiled beta-sheet: order of the first 5 strands: 23154
- DNA-binding domain of Mlu1-box binding protein MBP1 [54615] (1)
beta(4)-alpha(2)-beta(2)-alpha; antiparallel sheet: order 123465
- Heme-binding protein A (HasA) [54620] (1)
beta-alpha-beta(6)-alpha(2); antiparallel sheet: order 165432
- Chalcone isomerase [54625] (1)
beta(3)-alpha(2)-beta-alpha(2)-beta3; 2 layers alpha/beta; antiparallel sheet: order 1234567
- Coproporphyrinogen III oxidase [102885] (1)
alpha-beta(6)-alpha(2)-beta-alpha(n); 3 layers alpha/beta/alpha; antiparallel sheet: order 1234567
- Hypothetical protein Ta1206 [102890] (1)
beta(4)-alpha-beta(2)-alpha(2); mixed, predominately antiparallel beta-sheet, order: 123465, strands 4 and 5 are parallel to each other
- CBS-domain pair [54630] (1)
duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences; 4 layers: a/b/b/a
- Thioesterase/thiol ester dehydrase-isomerase [54636] (1)
core: beta-alpha-beta(4); 2 layers: alpha/beta
- DLC [54647] (1)
core: beta-alpha(2)-beta-X-beta(2); 2 layers: alpha/beta; antiparallel beta-sheet: order 1342
- CI-2 family of serine protease inhibitors [54653] (1)
alpha+beta sandwich; loop across free side of beta-sheet
- Integrin beta tail domain [69686] (1)
alpha-beta-loop-beta(3); loop across free side of beta-sheet
- YcgL-like [160190] (1)
beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet, order:3124
- alpha/beta-Hammerhead [54664] (5)
core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead motif similar to that in barrel-sandwich hybrids
- POZ domain [54694] (1)
core: beta(2)-alpha(2)-beta(2)-alpha(2); 2 layers a/b; mixed sheet: 2143
- EF-Ts domain-like [54712] (2)
beta(2)-alpha(n)-beta; 2 layers a/b; antiparallel sheet: 123
- Fe,Mn superoxide dismutase (SOD), C-terminal domain [54718] (1)
alpha-beta(2)-alpha-beta-alpha(2); 3 strands of antiparallel sheet: 213
- ClpS-like [54735] (1)
beta-alpha(2)-beta-alpha-beta; 2 layers, alpha/beta
- Hypothetical protein MTH1880 [75411] (1)
beta-alpha-beta(2)-alpha(2); 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
- Ribosomal L11/L12e N-terminal domain [54746] (1)
beta-alpha(2)-beta(2); 2 layers, alpha/beta; antiparallel beta-sheet: order 123
- Anti-LPS factor/recA domain [54751] (2)
alpha-beta(3)-alpha(2); 2 layers, alpha/beta
- Signal recognition particle alu RNA binding heterodimer, SRP9/14 [54761] (1)
(beta)-alpha-beta(3)-alpha; 2 layers, alpha/beta
- dsRBD-like [54767] (5)
alpha-beta(3)-alpha; 2 layers: alpha/beta
- 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain [110920] (1)
duplication: consists of two beta(3)-alpha repeats; 3 layers, beta/alpha/beta
- NMB0488-like [160206] (1)
duplication: two beta(3)-alpha motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456, shaped into a half-barrel; helical linker region
- SRP19 [69694] (1)
beta-alpha-beta(2)-alpha; 2 layers: alpha/beta
- SufE/NifU [82648] (1)
alpha(2)-beta(3)-alpha(3); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
- FlaG-like [160213] (1)
alpha(2)-beta(3)-alpha; 2 layers: a/b; antiparallel beta-sheet, order: 123; partial similatity to the dsRBD-like fold(sop_cf 54767)
- AMPKBI-like [160218] (1)
comprises 3 short helices and 3-stranded meander beta-sheet; makes extensive intermolecular interactions
- DNA-binding protein Tfx [89914] (1)
alpha(3)-beta-alpha(2)-beta(2); 2 layers alpha/beta, 3-stranded antiparallel beta-sheet; order 123
- Eukaryotic type KH-domain (KH-domain type I) [54790] (1)
beta-alpha(2)-beta(2)-alpha; 2 layers: alpha/beta
- Alpha-lytic protease prodomain-like [54805] (10)
core: alpha-beta(2)-(alpha)-beta; 2 layers: alpha/beta
- Nucleotidyltransferase [81302] (1)
core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123
- Nqo5-like [143242] (1)
core: alpha-beta(2)-alpha-beta(3); 2 layers, a/b; mixed beta-sheet, order 12534, strands 2 and 5 are parallel
- Ribosomal protein S3 C-terminal domain [54820] (1)
alpha(2)-beta(4); 2 layers: alpha/beta; antiparallel beta-sheet: order 2143
- Transcription factor NusA, N-terminal domain [69704] (1)
alpha-beta(3)-alpha-beta-alpha; bifurcated coiled beta-sheet
- Enolase N-terminal domain-like [54825] (1)
beta(3)-alpha(3); meander and up-and-down bundle
- Ribosomal protein L22 [54842] (1)
beta-alpha(3)-beta(2); 2 layers: alpha/beta; related to the enolase/MLE N-domain fold by a circular permutation
- Prokaryotic ribosomal protein L17 [64262] (1)
alpha-beta-alpha(3)-beta(2); 2 layers: alpha/beta;
- GroEL-intermediate domain like [54848] (1)
3-helical bundle packed against 3-stranded mixed beta-sheet
- PX domain [64267] (1)
beta(3)-alpha(4); meander beta-sheet packed against array of helices; contains Pro-rich stretch
- Shew3726-like [160271] (1)
beta(3)-alpha(n)-beta; 2 layers, a/b; mixed beta-sheet, order 1234, strands 3 and 4 are parallel with a left-handed crossover connection
- DsrC, the gamma subunit of dissimilatory sulfite reductase [69720] (1)
beta(3)-alpha(5); meander beta-sheet packed against array of helices
- DNA damage-inducible protein DinI [54856] (1)
beta-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed sheet 213; crossing loops
- HSP90 C-terminal domain [110941] (1)
alpha-beta(3)-alpha(3); 2 layers, a/b; mixed beta-sheet, order:132; crossing loops
- Ferredoxin-like [54861] (59)
alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
- PurS-like [109622] (1)
consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
- RplX-like [160373] (1)
beta(2)-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 213; some structural similarity to the PurS subunit/repeat (scop_cf 109622)
- Dystroglycan, domain 2 [111005] (1)
beta-alpha-beta-X-beta(2)-alpha(2)-beta; antiparallel beta-sheet, order 24153; topological similarity to the ferredoxin-like fold (scop_cf 54861)
- Pseudouridine synthase [100877] (1)
consists of two alpha+beta subdomains with some similarity to the ferredoxin-like fold
- SP0830-like [160378] (1)
duplication: two beta-alpha-beta(2)-alpha-beta-alpha motifs are organized in ferredoxin-like subdomains swapped with the extra C-terminal helices
- Folate-binding domain [103024] (1)
duplication: consists of two beta(2)-alpha-beta(3)-alpha subdomains swapped with the first strands
- THUMP domain [143436] (1)
contains mixed 8-stranded beta-sheet, folded into a half-barrel and covered with 4 helices on the outside; order 32148756; strands 5, 6 and 7 are parallel
- AMMECR1-like [143446] (1)
duplication; contains two beta(2)-alpha-beta(2) structural repeats, swapped with C-terminal strands; extra N-terminal helix and C-terminal strand
- NosL/MerB-like [160386] (1)
unusual fold; comprises two structural repeats of beta(2)-alpha-beta motifs, forming separate beta-sheets; probable duplication
- YehU-like [118000] (1)
beta-alpha(2)-beta(2)-alpha; 3 layers, alpha/beta/alpha; antiparallel beta-sheet: order 123
- Hypothetical protein YwqG [103031] (1)
duplication: contains two similar beta-x-beta(4) motifs swapped with the first strands
- VC0467-like [143455] (1)
complex fold; contains bifurcated beta-sheet structure folded into pseudo barrel
- Lesion bypass DNA polymerase (Y-family), little finger domain [100878] (1)
beta-alpha-beta(2)-alpha-beta; antiparallel beta-sheet: order 1423; "reversed" ferredoxin-like topology
- ImmE5-like [143468] (1)
alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order 213
- Ribosomal protein L30p/L7e [55128] (1)
core: beta-alpha-beta-alpha-beta; antiparallel beta-sheet: order 312; some similarity to the ferredoxin-like fold
- Chorismate lyase-like [64287] (1)
duplication of alpha(2)-beta(3) motif; antiparallel beta sheet, order 123654
- YdfO-like [160418] (1)
duplication: two alpha(2)-beta(3) motifs are related by pseudo twofold symmetry; single antiparrallel beta-sheet, order:321456
- TM1622-like [143476] (1)
alpha-beta(3)-alpha-beta(4)-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order: 1237654
- BH3703-like [160423] (1)
alpha-beta(3)-alpha-beta(2)-alpha(2); antiparallel beta-sheet, order:32145; duplication: two alpha-beta(2) structural repeats are arranged with pseudo twofold symmetry
- Probable bacterial effector-binding domain [55135] (1)
duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12)
- CheC-like [103038] (1)
duplication: tandem repeat of two intertwined alpha-beta-(X)-beta(2) motifs
- LigT-like [55143] (1)
duplication of beta-alpha-beta-alpha-beta motif: antiparallel beta sheet forms barrel (n=6, S=8) similar to the barrel of prokaryotic DNA topoisomerases I and III
- Pepsin inhibitor-3 [55148] (1)
duplication of beta(3)-alpha(2) motif: meander beta sheets form barrel-like structure
- CYTH-like phosphatases [55153] (1)
duplication of beta-alpha-beta(3) motif: antiparallel beta sheet forms wide barrel (n=8, S=16) with a channel running through it
- Antiparallel beta/alpha barrel (PT-barrel) [143491] (1)
tandem repeat of five alpha(2)-beta(2) motifs; antiparallel beta-sheet barrel, closed; n=10, S=10; order 123456789A; there is a channel along the barrel axis
- eIF1-like [55158] (2)
beta(2)-alpha-beta(2)-alpha-beta; 2 layers: alpha/beta; mixed beta-sheet: order 51243
- Hedgehog/DD-peptidase [55165] (1)
alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
- Alpha-L RNA-binding motif [55173] (1)
alpha(2)-beta(2)-loop-beta; 2 layers: alpha/beta
- RRF/tRNA synthetase additional domain-like [55185] (4)
core: alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta
- LuxS/MPP-like metallohydrolase [63410] (1)
core: beta-alpha-beta(2)-alpha(2); 2 layers: alpha/beta
- IF3-like [55199] (8)
beta-alpha-beta-alpha-beta(2); 2 layers; mixed sheet 1243, strand 4 is antiparallel to the rest
- PUG domain-like [143502] (1)
alpha(2)-beta-alpha(2)-beta(2)-alpha; cluster of helices with a small antiparallel beta-sheet on one side; order 132; topological similarity to the fold of an extended R3H domain (PDB 1whr)
- PG1857-like [160447] (1)
alpha-beta-alpha-beta(2)-alpha(3); 3 layers, a/b/a; antiparallel beta-sheet, order: 132
- PB2 C-terminal domain-like [160452] (1)
alpha-beta-alpha-X-alpha-beta(2); 3 layers, a/b/a; antiparallel beta-sheet, order 132; connection between helices 2 and 3 runs over the edge of the beta-sheet
- Ribosome binding protein Y (YfiA homologue) [69753] (1)
beta-alpha-beta(3)-alpha; 2 layers; mixed sheet 1234, strand 3 is antiparallel to the rest
- TolA/TonB C-terminal domain [74652] (1)
beta(2)-alpha-beta; 2 layers, alpha/beta; left-handed beta-alpha-beta unit in non-swapped monomer
- Yeast killer toxins [55220] (1)
beta-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta; left-handed crossover connection
- Cell division protein MinE topological specificity domain [55228] (1)
dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
- Hypothetical protein YoaG [103062] (1)
dimer of beta(2)-alpha motifs ; 2 layers, alpha/beta; reverse MinE topology
- BLRF2-like [160458] (1)
homodimer of alpha(2)-beta motif; also includes extra N-terminal helix of variable position
- Nucleocapsid protein dimerization domain [103067] (1)
dimer of alpha-beta(2)-alpha motifs ; 2 layers, alpha/beta
- Cyanase C-terminal domain [55233] (1)
intertwined dimer of alpha-beta(2) motifs ; 2 layers, alpha/beta
- Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains [82713] (1)
Intertwined pseudo hexamer of an alpha+beta motif
- RuBisCO, small subunit [55238] (1)
alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
- DCoH-like [55247] (5)
beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
- TRCF domain-like [143516] (1)
beta-alpha(3)-beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; mixed beta sheet, order 12354, strands 1 and 2 are parallel; some topological similarity to the DCoH-like fold (scop_cf 55247)
- NMB0513-like [160471] (1)
alpha(3)-beta(2)-alpha-beta(2); some similarity to the "winged helix" DNA-binding domain fold
- PA1123-like [160476] (1)
irregular array of short helices and two three-stranded beta-sheets
- Hypothetical protein Yml108w [100886] (1)
beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta; mixed beta-sheet 2143, strands 1 and 4 are parallel
- MutS N-terminal domain-like [55266] (2)
beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta
- GYF/BRK domain-like [55276] (2)
beta(2)-alpha-beta(2)-alpha; 2 layers, alpha/beta
- GTP cyclohydrolase I feedback regulatory protein, GFRP [69760] (1)
beta(2)-alpha-beta(2)-alpha-beta(2); 2 layers, alpha/beta, antiparallel beta-sheet: order 342165
- RL5-like [55281] (1)
beta-alpha-beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta; antiparallel beta-sheet: order 231654
- RPB5-like RNA polymerase subunit [55286] (1)
core: beta-alpha-beta-alpha-beta(2); 2 layers, alpha/beta
- Bacillus chorismate mutase-like [55297] (9)
core: beta-alpha-beta-alpha-beta(2); mixed beta-sheet: order: 1423, strand 4 is antiparallel to the rest
- YjbQ-like [111037] (1)
beta(2)-alpha-beta(2)-alpha(2)-beta(3); contains a beta-sandwich: 7 strands in 2 sheets; trimerizes with orthogonally packed beta-sheets
- Tautomerase/MIF [55330] (1)
(beta-alpha-beta)2; 2 layers: alpha/beta; mixed beta-sheet
generally forms trimers with three closely packed beta-sheets
- FwdE/GAPDH domain-like [55346] (4)
core: alpha-beta-alpha-beta(3); mixed sheet: 2134, strand 2 is parallel to strand 1
- Ava3019-like [160531] (1)
alpha(2)-beta-alpha-beta(4); 2 layers, a/b; antiparallel beta-sheet, order: 32145; similarity to the insert domain of Glucose 6-phosphate dehydrogenase-like family (sop_fa 55376)
- Hypothetical protein PF0899 [111056] (1)
alpha-beta-alpha-beta(4); 2 layers: a/b; mixed beta-sheet, order 23145, strands 1 and 3 are parallel; similar to the GAPDH C-terminal domain-like fold (scop_cf 55346)
- Major capsid protein gp5 [56562] (1)
unusual fold; contains PF0899-like core, decorated with additional structure
- MK0786-like [143559] (1)
alpha(2)-beta(4); 2 layers: a/b; antiparallel beta-sheet, order 1234 (meander)
- YkuJ-like [143566] (1)
alpha-beta(4)-alpha; 2 layers a/b; antiparallel beta-sheet, order 1234
- N domain of copper amine oxidase-like [55382] (5)
alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet
- Aha1/BPI domain-like [55393] (2)
core: [beta]-alpha-beta(5)-alpha; 2 layers: alpha/beta; antiparallel beta-sheet, meander
- SpoVG-like [160536] (1)
beta(5)-alpha; comprises a coiled antiparallel beta-sheet (order: 12345) packed against the C-terminal helix; the extensions of strands 4 and 5 form an isolated beta-hairpin
- Subtilisin inhibitor [55398] (1)
alpha+beta sandwich
- RNA bacteriophage capsid protein [55404] (1)
6-standed beta-sheet followed with 2 helices; meander
- eIF4e-like [55417] (1)
beta(2)-alpha-beta(2)-alpha-beta(2)-alpha-beta-2; 2 layers: alpha/beta; antiparallel sheet: 21356478
- CO dehydrogenase flavoprotein C-domain-like [55423] (2)
core: beta(3,4)-alpha(3); alpha+beta sandwich
- SRF-like [55454] (1)
alpha-beta(2)-alpha; dimer; 3 layers a/b/a; antiparallel beta-sheet
- Origin of replication-binding domain, RBD-like [55463] (1)
alpha-beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel sheet 41325
- SARS receptor-binding domain-like [143586] (1)
core: 3 layers, a/b/a; antiparallel beta-sheet of 5 strands, order 13542
- Hut operon positive regulatory protein HutP [111063] (1)
alpha(2)-beta-alpha(2)-beta(3); 3 layers: a/b/a; antiparallel beta-sheet: order 1234
- Hypothetical protein yfbM [111068] (1)
beta-alpha(2)-beta-alpha(2)-beta(2)-alpha(n)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 21543
- TTHA1528-like [143591] (1)
beta-alpha-beta(3)-alpha-beta-alpha(2)-beta; 3 layers: a/b/a; mixed beta-sheet, order: 143256, parallel strands' pairs are 1-4 and 2-5
- YojJ-like [143596] (1)
alpha-beta-X-beta-alpha-beta(2)-alpha-beta(3); 3 layers: a/b/a; 7-stranded mixed beta-sheet, order 2431567; strands 1 and 3 are parallel to each other
- STIV B116-like [143601] (1)
subunit fold consists of mixed 5-stranded beta-sheet, order:31452, strand 5 is antiparallel to the rest, with 3 helices on one side; dimerises with the formation of a single 10-stranded beta-sheet; strand 2 is in the dimer interface
- Bacillus phage protein [111073] (1)
alpa-beta(3)-alpha-beta(3)-alpha; 3 layers: b/a/b, 3-helical bundle flanked by two 3-stranded meander beta-sheets
- FMN-dependent nitroreductase-like [55468] (1)
core: (alpha-beta-alpha-beta)2; 3 layers a/b/a; antiparallel beta-sheet: 1243
- N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 [55480] (1)
alpha-beta-alpha(2)-beta(3)-alpha; 3 layers a/b/a; antiparallel beta-sheet: 4123
- EscU C-terminal domain-like [160543] (1)
alpha-beta(3)-alpha-beta-alpha(2); 3 layers, a/b/a; mixed beta-sheet, order: 4123, strand 2 is antiparallel to the rest
- Zincin-like [55485] (2)
contains mixed beta sheet with connection over free side of the sheet
- SH2-like [55549] (1)
3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
- HPr-like [55593] (2)
beta-alpha-beta(2)-alpha-beta-alpha; 2 layers: a/b; antiparallel sheet 1423
- TrkA C-terminal domain-like [116725] (1)
beta-X-beta(2)-X-beta-alpha; pseudo barrel capped by helix at one end; topological similarity to the HPr-like fold
- Hypothetical protein YjiA, C-terminal domain [90001] (1)
beta-alpha-beta(4)-alpha; 2 layers: a/b; antiparallel sheet 15234; topological similarity to the HPr-like fold
- YggU-like [69785] (1)
beta(2)-loop-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243; some similarity to the Homing endonuclease-like fold
- Homing endonuclease-like [55603] (2)
alpha-beta(2)-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243
- T-fold [55619] (2)
beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
tunnel-shaped: its known members form wide oligomeric barrels different sizes
- Cell cycle regulatory proteins [55636] (1)
beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1243
can form strand-exchange dimers
- YonK-like [160569] (1)
intertwined dimer of beta(3)-alpha-beta subunits; assembles further in octamer with formation of a wide 16-stranded beta-barrel
- BLIP-like [55647] (2)
alpha(2)-beta(4); 2 layers: alpha/beta
- Ribosomal protein L9 C-domain [55652] (1)
alpha-beta-alpha(2)-beta(2); 2 layers: alpha/beta
- MbtH/L9 domain-like [55657] (2)
beta(2)-alpha-beta-alpha; 3 layers: alpha/beta/alpha
- Tombusvirus P19 core protein, VP19 [103144] (1)
beta(2)-alpha-beta(2)-alpha; 2 layers: alpha/beta; antiparallel sheet: order 2134
- Ribonuclease PH domain 2-like [55665] (1)
beta(2)-alpha-beta(2)-alpha; 3 layers: alpha/beta/alpha; antiparallel sheet: order 2134
- Regulatory factor Nef [55670] (1)
alpha(2)-beta(4)-alpha; 3 layers: alpha/beta/alpha
- CytB endotoxin-like [55675] (1)
core: beta-alpha(2)-beta-alpha(2)-beta(4); 3 layers: a/b/a
- Class II aaRS and biotin synthetases [55680] (1)
contains large mixed beta-sheet
- Subdomain of clathrin and coatomer appendage domain [55710] (1)
beta-alpha-beta-alpha-beta(4)-alpha; 3 layers: a/b/a; bifurcated antiparallel beta-sheet
- SCP-like [55717] (1)
alpha-beta(3)-(crossover)-beta-(alpha)-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 32145
- Ta1353-like [103164] (1)
core: beta-alpha-beta(2)-alpha-beta-alpha-beta; 3 layers: a/b/a; antiparallel beta-sheet of 5 strands; order: 51423;
- Mog1p/PsbP-like [55723] (1)
(beta-hairpin)-beta(3)-alpha-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet of 7 strands; order: 1237654
- SMI1/KNR4-like [160630] (1)
alpha(4)-beta(4)-alpha; 3 layers: a/b/a; antiparallel beta-sheet, order 1234(meander)
- Acyl-CoA N-acyltransferases (Nat) [55728] (1)
3 layers: a/b/a; contains mixed beta-sheet
- Gelsolin-like [55752] (3)
3 layers: a/b/a; contains mixed beta-sheet
- PHP14-like [143723] (1)
beta(3)-alpha-beta(2)-alpha-beta; 3 layers, a/b/a; mixed beta-sheet, half-barrel, order: 132456; strands 2 and 5 are antiparallel to the rest
- Profilin-like [55769] (10)
core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha
- Ligand-binding domain in the NO signalling and Golgi transport [111125] (1)
an N-terminal helical bundle and the C-terminal alpha-beta(2)-alpha-beta(2) subdomain enclose a ligand-binding cavity
- Phage tail protein-like [143748] (1)
alpha-beta-X-beta(2)-alpha-beta(2); 2 layers: a/b; mixed beta-sheet: order 12354, strands 1 and 2 are parallel
- PR-1-like [55796] (1)
alpha-beta-alpha-beta-alpha(2)-beta(2); 3 layers, alpha/beta/alpha; mixed sheet: order 1342
- Phoshotransferase/anion transport protein [55803] (1)
beta-alpha(2)-beta(3)-alpha(3); 3 layers, alpha/beta/alpha; mixed sheet: order 1342; loop crossing
- Nudix [55810] (1)
beta(2)-alpha-beta(3)-alpha; 3 layers: alpha/beta/alpha; mixed sheet
contains beta-grasp motif
- 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain [55815] (1)
core: alpha-beta(2)-alpha-beta(2)-alpha-beta; 3 layers; mixed sheet: order 31425
- YrdC/RibB [55820] (1)
core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta; 3 layers; mixed twisted sheet of 7 strands; order 7126354; strands 7 and 1 are parallel to each other
- GIY-YIG endonuclease [82770] (1)
beta(2)-alpha(2)-beta-alpha-(beta); strand 4 is very short; 3 layers; antiparallel (mixed) beta-sheet; order 312(4)
- YbaK/ProRS associated domain [55825] (1)
core: alpha-beta-alpha-beta(2)-(alpha-beta)2-alpha-beta(2)-alpha-beta; 3 layers; bifurcated mixed sheet
- Thymidylate synthase/dCMP hydroxymethylase [55830] (1)
contains large mixed beta-sheet
- Thymidylate synthase-complementing protein Thy1 [69795] (1)
complex alpha+beta fold; contains antiparallel 5-stranded beta-sheet: order 12354
- N-acetylmuramoyl-L-alanine amidase-like [55845] (1)
contains mixed beta-sheet
- Cytochrome b5-like heme/steroid binding domain [55855] (1)
beta-alpha-beta(2)-alpha(1,2)-(beta)-alpha(2)-beta; 3 layers: a/b/a; antiparallel beta-sheet, order: 1532(4)
- BTG domain-like [160695] (1)
alpha(2)-beta-alpha(2)-beta(3); four-helical bundle, capped at one end by an antiparallel beta-sheet, order:1234
- DUSP-like [143790] (1)
alpha-beta-alpha-X-beta-alpha-beta; three-helical bundle capped at one end by antiparallel beta-sheet, order: 213
- DNA topoisomerase I domain [55868] (1)
beta(2)-alpha-beta-(alpha)-beta(2); left-handed crossover between strands 2 & 3
- ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1)
8-stranded mixed beta-sheet; 2 layers: alpha/beta
- YehR-like [160703] (1)
beta(3)-alpha-beta(2)-alpha(3)-beta; 2 layers, a/b; antiparallel beta-sheet, order: 612354
- Sporulation response regulatory protein Spo0B [55889] (1)
core: alpha-beta-alpha-beta(2)-(alpha)-beta(2)
- Ribonuclease Rh-like [55894] (1)
alpha+beta fold
- YlxR-like [64375] (1)
alpha+beta fold; could have evolved from a glucocorticoid receptor-like zinc finger domain
- YggX-like [111147] (1)
beta(2)-alpha(3); contains zinc-less 'zinc finger'-like fold (scop_cf 57715; see also scop_cf 64375)
- L28p-like [143799] (1)
unusual fold consisting of three beta-hairpins, that form a paper clip-like structure, and two helices; could have evolved from a glucocorticoid receptor-like zinc finger domain (scop_cf 57715)
- YqaI-like [160712] (1)
dimeric zinc-less 'zinc finger'-like fold; similar to the C-terminal strand-swapped B-box domain (scop_cf 57844)
- Ornithine decarboxylase C-terminal domain [55903] (1)
complex alpha+beta motif
- Pentein, beta/alpha-propeller [55908] (1)
duplication: composed of 5 alpha-beta(2)-alpha-beta units arranged around pseudo fivefold axis
- Creatinase/aminopeptidase [55919] (1)
duplication: composed of two very similar alpha+beta folds
- gpW/gp25-like [160718] (1)
alpha(2)-beta(3); similar to one structural repeat of the Creatinase/aminopeptidase family and the C-terminal subdomain of PanC
- Glutamine synthetase/guanido kinase [55930] (1)
duplication: common core consists of two beta-alpha-beta2-alpha repeats
- TBP-like [55944] (11)
beta-alpha-beta(4)-alpha
- XisI-like [143846] (1)
alpha-beta(4)-alpha-beta-alpha; 2 layers, a/b; antiparallel beta-sheet, order 1234, meander; the open side of beta-sheet provides dimerization interface
- S-adenosylmethionine synthetase [55972] (1)
duplication: consists of 3 similar intertwined domains
structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta
- DNA clamp [55978] (1)
contains two helices and two beta sheets
duplication: fold has internal pseudo two-fold symmetry
- Hypothetical protein TM0160 [103255] (1)
duplication: consists of two beta(3)-alpha(2) structural repeats; single barrel-like beta-sheet
- TTHC002-like [160760] (1)
alpha-beta-alpha-beta(3); forms dimer with a single beta-sheet, folded in a barrel-like shape
- Molybdenum cofactor-binding domain [56002] (1)
beta(2)-alpha-beta-alpha-beta; 2 layers: a/b; mixed sheet: order 1243: crossing loops
- NE1680-like [160765] (1)
beta(2)-alpha-beta-alpha-beta; 2 layers, a/b; antiparallel sheet, order 3124
- Nitrite and sulphite reductase 4Fe-4S domain-like [56013] (1)
beta-alpha-beta-alpha-beta(3)-alpha(2,3); mixed sheet: order 12345; left-handed crossover connection between strands 1 and 2
- DeoB insert domain-like [143855] (1)
alpha-beta-X-beta(2)-alpha-beta(2); 2 layers, a/b; mixed beta-sheet of 5 strands, order 12345; strands 2 and 5 are antiparallel to the rest
- The spindle assembly checkpoint protein mad2 [56018] (1)
core: alpha(2)-beta(2)-alpha-beta; mixed sheet: order 213
- Phospholipase D/nuclease [56023] (1)
beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234
- CorA soluble domain-like [143864] (1)
beta(2)-alpha-beta-alpha(2)-beta(4)-alpha(3); 3 layers: a/b/a; mixed beta-sheet, order 2137654; strands 3 and 7 are parallel
- Monooxygenase (hydroxylase) regulatory protein [56028] (1)
corner-like structure formed by two sheets and filled in with 2-3 helices
- PurM C-terminal domain-like [56041] (1)
3 layers: alpha/beta/alpha; partial topological similarity to the ferredoxin-like fold
- PF0523-like [143869] (1)
beta-alpha-beta-alpha(3)-beta-alpha-beta-alpha; 3 layers, a/b/a; antiparallel beta-sheet, order 4132; some similarity to the PurM C-terminal domain-like fold (scop_cf 56041)
- Chorismate synthase, AroC [103262] (1)
duplication: consists of two DCoH-like beta(2)-alpha-beta(2)-alpha structural repeats; 3 layers, beta/alpha/beta
- Hsp33 domain [64396] (1)
3 layers: beta/alpha/beta; buried helix
- MTH1598-like [69818] (1)
beta(2)-alpha-beta-alpha-beta(4); 3 layers: beta/alpha/beta; some similarity to the Hsp33 fold
- Protein-L-isoaspartyl O-methyltransferase, C-terminal domain [68929] (1)
beta-alpha-beta(4)-alpha-beta(2); 3 layers: beta/alpha/beta; buried helix
- OsmC-like [82783] (1)
swapped dimer of beta(3)-alpha-beta(2)-alpha(2)-beta subunits; mixed beta-sheet; order: 321[4][5][6]; buried helix
- Hypothetical protein HI1480 [103276] (1)
beta-alpha(4)-beta-alpha-beta; segregated alpha-helical and beta-sheet subdomains; dimeric beta-sheet barrel: n=6, S=10
- ERH-like [143874] (1)
beta(2)-alpha(2)-beta(2)-alpha; antiparallel beta-sheet, order:2134; helices are arranged in a bundle rather than packed agains beta-sheet; dimerises via with the formation of a flattened beta-barel: closed n=8, S=10
- Ribosomal protein S8 [56046] (1)
consists of 2 different alpha+beta subdomains arranged in a 4-layer structure: b/a/b/a
- Ribosomal protein L6 [56052] (1)
consists of two beta-sheets and one alpha-helix packed around single core
- NE0471 N-terminal domain-like [143879] (1)
beta(3)-alpha(n)-beta(3)-alpha; the two meander beta-sheets and helices are packed against the same core
- Lp2179-like [160799] (1)
beta(2)-alpha-beta(4)-alpha-beta; contains two antiparallel beta-sheets (orders: 127 and 3456) packed against the longer C-terminal helix