SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Original-Style Sequences 2.06

  • Explanation: A SCOPe domain may include fragments from different PDB chains (see d1cph.1, for example). A genetic domain is a SCOPe domain in which the fragments are concatenated in the order in which they appear in the original gene or sequence. In the original-style Astral SCOPe sequence sets, there is a separate entry for each chain (the section of d1cph.1 in chain A: becomes e1cph.1a, and the part in chain B: becomes e1cph.1b). In the genetic domain sequence sets, there is a single entry, g1cph.1, in which the sequences for chains B: and A: appear in the correct order, separated by the letter 'X'.
    Genetic domain sequences are now the default.

  • If you don't want original-style sequences, click here for the genetic domain (standard) sequences.

    Most commonly requested files:

    • Astral SCOPe 2.06 original-style sequence subsets, based on PDB SEQRES records,
      with less than 40% identity to each other: download sequences (3.7 MB)
    • Astral SCOPe 2.06 original-style sequence subsets, based on PDB SEQRES records,
      with less than 95% identity to each other: download sequences (7.3 MB)

  • All Astral SCOPe original-style sequences, based on PDB SEQRES records: download sequences (61.4 MB)

  • All Astral SCOPe original-style sequences, based on PDB ATOM records: download sequences (60.9 MB)
    These are not recommended unless you have a special need.

  • Percentage identity-filtered Astral SCOPe original-style sequence subsets, based on PDB SEQRES records.
    with less than percent identity (using "in both" criterion).

  • E-value filtered Astral SCOPe original-style sequence subsets, based on PDB SEQRES records.
    with E-values >= (in a database size of 100,000,000 residues).
  • SCOPe filtered Astral SCOPe original-style sequence subsets, based on PDB SEQRES records.
    that represent each in SCOPe.