Welcome to the SCOPe website!

The SCOPe website provides integrated access to all data from the SCOP and ASTRAL databases, starting with version 1.55, the first version featuring stable identifiers. All releases from 1.55 to the current release can be found under the Stats & History tab.

Authors

  • The SCOP authors are Alexey G. Murzin, John-Marc Chandonia, Antonina Andreeva, Dave Howorth, Loredana Lo Conte, Bartlett G. Ailey, Steven E. Brenner, Tim J. P. Hubbard, and Cyrus Chothia.
  • The ASTRAL authors are John-Marc Chandonia, Naomi K. Fox, Degui Zhi, Gary Hon, Loredana Lo Conte, Nigel Walker, Patrice Koehl, Michael Levitt, and Steven E. Brenner.
  • References to cite are on this page.
Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Four proposals to the NIH for continued funding have been unsuccessful. Although Dr. Chandonia has obtained sufficient funding on other projects to remain employed for another year, SCOPe may shut down permanently in Summer 2018 as Dr. Chandonia will need to seek a new position.

Synopsis and News

Nearly all proteins have structural similarities with other proteins and, in some of these cases, share a common evolutionary origin. The SCOP database, created by manual inspection and abetted by a battery of automated methods, aims to provide a detailed and comprehensive description of the structural and evolutionary relationships between all proteins whose structure is known. As such, it provides a broad survey of all known protein folds, detailed information about the close relatives of any particular protein, and a framework for future research and classification.

The Astral compendium provides databases and tools useful for analyzing protein structures and their sequences. It is partially derived from, and augments SCOP(e). Most of the resources provided here depend upon the coordinate files maintained and distributed by the Protein Data Bank.

License

Since 2004-07-01, all SCOP data have been freely available to all users, according to the license agreement. All ASTRAL data are also freely available to all users.

Funding

This work was supported by the National Institutes of Health (R01-GM073109) through the U.S. Department of Energy under Contract No. DE-AC02-05CH11231.